Sentences with phrase «virus in nonhuman»

«Antiviral compound provides full protection from Ebola virus in nonhuman primates.»

«This is the first example of a small molecule — which can be easily prepared and made on a large scale — that shows substantive post-exposure protection against Ebola virus in nonhuman primates,» Bavari commented.

Led by Bavari and Travis Warren, Ph.D., the USAMRIID team performed a series of studies involving a lethal challenge with Marburg virus in nonhuman primates to determine the efficacious dose and regimen of AVI - 7288, as well as to characterize the drug exposures in animals that produced efficacy.

«Results described in this manuscript provide a comprehensive characterization of the efficacy of the PMO antisense platform against Marburg virus in nonhuman primates and its safety profile in humans,» Bavari said.

Not exact matches

Ebola virus causes severe hemorrhagic fever in humans and nonhuman primates with high mortality rates and continues to emerge in new geographic locations, including West Africa, the site of the largest outbreak to date.

Detection and molecular characterization of Ebola viruses causing disease in human and nonhuman primates

Tekmira siRNAs and ZMapp «are both head and shoulders above everything else in terms of demonstrated efficacy in nonhuman primates,» says Thomas Geisbert, an expert on Ebola virus at The University of Texas Medical Branch at Galveston who has worked on most of the experimental treatments and vaccines under consideration.

This virus, which is in the same family as Ebola, has a rapid disease course (seven to nine days) in nonhuman primates.

For the first time, researchers at the University of Texas Medical Branch at Galveston, in collaboration with Tekmira Pharmaceuticals, have protected nonhuman primates against Marburg virus - Angola hemorrhagic fever.

«Antiviral compound protects nonhuman primates against Marburg virus: Safety profile also evaluated in phase I clinical trial.»

The simian foamy virus — so - called because of its foamy appearance under a microscope — is one of three known retroviruses in nonhuman primates.

The sooty mangabey, found in West Africa, has somehow adapted to the simian immunodeficiency virus — the nonhuman version of HIV — so that even with a high viral load, it rarely gets sick.

«Our genetic relatedness and close ecological connection to nonhuman primates seems to predispose us to sharing viruses — and that can happen in both directions,» he says.

Adenoviruses, first isolated in the 1950s from explanted adenoid tissue, are double - stranded nonenveloped DNA viruses that naturally infect many vertebrates, including humans and nonhuman primates.

The vaccines were evaluated for immunogenicity and efficacy; however, because of the previous report of immunopathology on challenge of ferrets and nonhuman primates that had been vaccinated with a whole virus adjuvanted vaccine and mice that had been vaccinated with a VLP vaccine, the primary orientation was to assess for immunopathology among animals in relation to type of vaccine, dosage, serum antibody responses, and virus infection.

Evaluations of an inactivated whole virus vaccine in ferrets and nonhuman primates and a virus - like - particle vaccine in mice induced protection against infection but challenged animals exhibited an immunopathologic - type lung disease.

This experiment was conducted to verify the findings in the initial experiment of a hypersensitivity immunopathologic - like reaction after SARS - CoV challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still exhibit a similar reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had shown an immunopathologic - like reaction after challenge of vaccinated ferrets and nonhuman primates exhibited a similar immunopathologic reaction in the mouse model [13], [14].

Scientists have identified potential biomarkers in nonhuman primates exposed to Ebola virus (EBOV) that appeared up to four days before the onset of fever, according to research published today in the journal Science Translational Medicine.

Superior efficacy of a human immunodeficiency virus vaccine combined with antiretroviral prevention in simian - human immunodeficiency virus - challenged nonhuman primates.

Cells increase before zoster and PD - 1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus.