Researchers from the University of Helsinki have shown that three anti-influenza compounds effectively inhibit Zika
virus infection in human cells.
«Damaging consequences of Zika
virus infection in human minibrains: Zika virus reduces growth, induces cell death, malformations in human neurospheres, brain organoids.»
These structures can be mutated to better understand how they influence the Zika
virus infection in humans and can also potentially lead to the development of a safe vaccine that has reduced side effects.»
Dr Peter Barlow says study represents a promising step forward in the rapid development of a safe and robust vaccine against Zika
virus infection in humans.
Dating the origin and dispersal of hepatitis B
virus infection in humans and primates.
Not exact matches
HIV
Infections Attributed to Male - to - Male S@xual Contact — Metropolitan Statistical Areas, United States and Puerto Rico, 2010 Weekly November 30, 2012 / 61 (47); 962 - 966 Human immunodeficiency virus (HIV) infections attributed to male - to - male s@xual contact comprised 64 % of the estimated new HIV infections in the United States in
Infections Attributed to Male - to - Male S@xual Contact — Metropolitan Statistical Areas, United States and Puerto Rico, 2010 Weekly November 30, 2012 / 61 (47); 962 - 966
Human immunodeficiency
virus (HIV)
infections attributed to male - to - male s@xual contact comprised 64 % of the estimated new HIV infections in the United States in
infections attributed to male - to - male s@xual contact comprised 64 % of the estimated new HIV
infections in the United States in
infections in the United States
in 2009 (1).
These include the infant with galactosemia, 53,54 the infant whose mother uses illegal drugs, 55 the infant whose mother has untreated active tuberculosis, and the infant
in the United States whose mother has been infected with the human immunodeficiency virus.56, 57 In countries with populations at increased risk for other infectious diseases and nutritional deficiencies resulting in infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring human immunodeficiency virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporaril
in the United States whose mother has been infected with the
human immunodeficiency
virus.56, 57
In countries with populations at increased risk for other infectious diseases and nutritional deficiencies resulting in infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring human immunodeficiency virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporaril
In countries with populations at increased risk for other infectious diseases and nutritional deficiencies resulting
in infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring human immunodeficiency virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporaril
in infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring
human immunodeficiency
virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporarily.
Affecting sexually active women,
in 99.7 % of all cases cervical cancer results from a history of
infection by a group of
viruses called
human papillomavirus - or HPV.
Hepatitis is a highly prevalent
infection, the World Hepatitis Alliance estimates that as many as one person
in 12 worldwide may be infected with the blood - borne strains Hepatitis B or C, which are passed on
in similar ways to the
Human Immunodeficiency
Virus (HIV).
These findings allowed researchers to create a chimera
virus: a mouse
virus with a
human viral gene that can be used to test molecules that inhibit
human LANA protein
in an animal model of disease, treating not only
human herpes
virus infection but also its associated cancers.
Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera
virus that allows the study of molecules to treat cancers caused by
human herpes
virus infection in mice models of disease.
«Our research is the first to study Zika
infection in a mouse model that transmits the
virus in a way similar to
humans,» explains Alysson R. Muotri, Ph.D., professor and director of the Stem Cell Program at UC San Diego and co-senior author of the study.
«This raises important questions about whether
human norovirus infects tuft cells and whether people who have chronic norovirus
infections and continue to shed the
virus long after
infection do so because the
virus remains hidden
in tuft cells,» Wilen said.
The vaccination protects against
infection from the two types of
Human Papilloma
Virus that cause seven in 10 cases of cervical cancer, as well as two other types of the virus linked with genital w
Virus that cause seven
in 10 cases of cervical cancer, as well as two other types of the
virus linked with genital w
virus linked with genital warts.
But the new test found another seven, including a respiratory
virus called
human adenovirus B type 3A, which usually is harmless but can cause severe
infections in some patients.
Among the copious species of poultry
in China, quail and chickens are the likely sources of
infection of H7N9 influenza
virus to
humans, according to a paper published ahead of print
in the Journal of Virology.
The
human infection most closely related to it is SARS, a bat
virus that jumped to
humans and spread worldwide
in 2003 — notably among healthcare workers.
But the episode makes epidemiologists fear there could be undiscovered milder cases of
infection by the
virus, perhaps
in younger people with no additional health problems, allowing the MERS
virus to evolve adaptations that will help it spread between
humans.
Understanding how the
virus operates offers a pathway to designing antiviral drugs as well as new vaccines to control bluetongue and related viral
infections in animals and
humans.
The
virus has caused 1,564 reported
human infections to date
in several epidemic waves (SN: 3/22/14, p. 32), and 39 percent of people infected have died.
In March 2013 the first human infections with the avian influenza A (H7N9) virus were reported in China, and since that time hundreds of cases have been documente
In March 2013 the first
human infections with the avian influenza A (H7N9)
virus were reported
in China, and since that time hundreds of cases have been documente
in China, and since that time hundreds of cases have been documented.
The newly discovered
viruses appeared
in every family or genus of RNA
virus associated with vertebrate
infection, including those containing
human pathogens such as influenza
virus.
Unlike other
human antibodies under investigation that recognize both Zika and the closely related dengue
virus, the antibodies used
in this study exclusively target Zika, demonstrating a high specificity that could be important
in avoiding potential side effects — such as enhanced dengue
infection in regions where both
viruses are endemic.
«
In that paper, we found a common response by the
human immune system to multiple
viruses that is distinct from that for bacterial
infections.
«RNA interference is activated
in human response to influenza, other important
viruses: Discovery could lead to better ways of combating serious
infections, including Ebola and Zika.»
In a new study, Yale researchers demonstrate Zika
virus infection of cells derived from
human placentas.
The paper focuses on two key molecular players
in the story of influenza
infection: a
human protein called TRIM25, which was recently discovered to play an important role
in the
human immune response to flu
infection; and a protein called NS1 present
in all strains of the influenza A
virus and shown to bind TRIM25 to keep it from doing its job.
In the search for mechanisms, some scientists have focused on the
virus, while others prefer to examine the
human host and his or her susceptibility to
infection.
«However, the fact that the emerging H7N9
virus has caused
infection mainly
in individual
human cases suggests that it has not acquired all the necessary properties for efficient transmission among
humans,» notes Dr. Kuiken.
Acute
infections in male marmosets, a New World monkey, resemble the
human illness the Zika
virus creates
in people, including the presence of the
virus in semen, saliva and urine up to two weeks after the initial
infection.
«It appears that pregnant women infected with Zika can pass the
virus to babies
in utero and that newborns also may be susceptible to
infection,» said Diamond, also an associate director of the university's Center for
Human Immunology and Immunotherapy Programs.
Researchers have used radioimmunotherapy (RIT) to destroy remaining
human immunodeficiency
virus (HIV)- infected cells
in the blood samples of patients treated with antiretroviral therapy, offering the promise of a strategy for curing HIV
infection.
The mouse model mimics aspects of the
infection in humans, with high levels of the
virus seen
in the mouse brain and spinal cord, consistent with evidence showing that Zika causes neurological defects
in human fetuses.
The first report of
infections of
humans with the influenza A
virus of the subtype H7N9 surfaced
in March 2013.
In Britain, in 1991, researchers led by Jim Stott at the National Institute of Biological Standards and Control in north London, stunned their colleagues by announcing that they had apparently protected monkeys from infection with the monkey virus SIV — the simian equivalent of HIV — with a vaccine based simply on human T cell
In Britain,
in 1991, researchers led by Jim Stott at the National Institute of Biological Standards and Control in north London, stunned their colleagues by announcing that they had apparently protected monkeys from infection with the monkey virus SIV — the simian equivalent of HIV — with a vaccine based simply on human T cell
in 1991, researchers led by Jim Stott at the National Institute of Biological Standards and Control
in north London, stunned their colleagues by announcing that they had apparently protected monkeys from infection with the monkey virus SIV — the simian equivalent of HIV — with a vaccine based simply on human T cell
in north London, stunned their colleagues by announcing that they had apparently protected monkeys from
infection with the monkey
virus SIV — the simian equivalent of HIV — with a vaccine based simply on
human T cells.
The new insights may one day help prevent
infections by related
viruses — some of which are linked to cancers
in humans.
Clinicians treating patients suffering from Middle East respiratory syndrome (MERS) currently have no drugs specifically targeted to the MERS coronavirus (MERS - CoV), a
virus first detected
in humans in 2012 that has since caused 614 laboratory - confirmed
infections, including 181 that were fatal, according to the World Health Organization.
The
virus is common
in dromedary camels, which can be a source of
human infections.
The UNC research team, led by Lemon and Jason Whitmire, Ph.D., Associate Professor
in UNC's Department of Genetics, is now poised to investigate the complicated interplay of nonspecific «innate» and specific «adaptive» immune responses that ultimately control the
infection and eliminate HAV from the host — processes that are not well understood for any of the five
human hepatitis
viruses.
Researchers found 53 existing drugs that may keep the Ebola
virus from entering
human cells, a key step
in the process of
infection, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and the National Institutes of Health (NIH), and published today
in the Nature Press journal Emerging Microbes and
Infections.
Scientists pre-treated
human liver cells
in vitro with SBEL1 prior to HCV
infection and found that SBEL1 pre-treated cells contained 23 percent less HCV protein than the control, suggesting that SBEL1 blocks
virus entry.
Kang found Korean red ginseng extract improved the survival of
human lung epithelial cells against RSV
infection and inhibited the
virus from replicating, or multiplying,
in the body.
Further testing and
human clinical trials are needed to determine if favipiravir, also known as T - 705 and Avigan, could effectively treat Lassa
virus infection in people.
Four weeks later, mice that had received the DNA vaccine were exposed to the Brazilian strain of Zika
virus known to cause fetal birth defects
in mice analogous to those seen following fetal Zika
infection in humans.
«The unfortunate news of the
virus rebounding
in this child further emphasizes the need to understand the early and refractory viral reservoir that is established very quickly following HIV
infection in humans,» adds Barouch, a Professor of Medicine at Harvard Medical School.
Watkins and Dennis Burton, Ph.D., chairman and professor of the Department of Immunology & Microbiology at the Scripps Research Institute, led the collaborative international study, «Neutralizing
Human Monoclonal Antibodies Prevents Zika
Virus Infection in Macaques,» published recently
in Science Translational Medicine.
These images provide the first 3D ultrastructural details on HIV
infection and
virus production
in a setting that closely resembles the gut of
human patients.
While most West Nile
Virus (WNV) infections in humans are asymptomatic and go unnoticed, the virus causes serious and sometimes fatal neurologic illness in some pe
Virus (WNV)
infections in humans are asymptomatic and go unnoticed, the
virus causes serious and sometimes fatal neurologic illness in some pe
virus causes serious and sometimes fatal neurologic illness
in some people.
FMD
in people is unrelated to hand, foot, and mouth disease, a
human infection with the same symptoms, caused by the Coxsackie A16
virus and several enteroviruses.
In humans, Zika
virus infection during pregnancy has been linked to a suite of birth defects including a condition known as microcephaly, which leaves babies with shrunken heads and brains (SN: 4/2/16, p. 26).