Sentences with phrase «virus vector»

Subretinal injections of adeno - associated virus vectors expressing RPE65 resulted in restoration of rod photoreceptor function and improved visual function, first in dogs [61, 62] and subsequently in humans [63 — 65].

The use of this foamy virus vector as a clinical vector for gene delivery was developed in Kiem's Clinical Research Division lab.

The study, published in Molecular Therapy, examined adeno - associated viruses (AAVs), the most commonly used virus vectors for delivering gene therapies.

GenPhar's main thrust, according to Schmaljohn, was the «technology edge» it brought to virus vector development - particularly work on a non-replicating adenovirus that could express multiple proteins.

Both assays (for translation enhancement and internal ribosomal initiation) were validated under cell - free conditions and in human cells, using a vaccinia virus vector.

They supported a range of studies, from work on gene therapy tools (including adenovirus and rous sarcoma virus vectors) to development of a new vaccine for the deadly Marburg virus.

Neitz and his wife, Maureen Neitz, also in the U.W. ophthalmology department, and the rest of their team have pinpointed that gene and developed a working virus vector to carry a functional copy of it.

2009 — Developed an MVA HIV Vaccine Candidate — MHRP and NIAID researchers developed a new HIV vaccine, specific to the strain of HIV circulating in Southeast Asia that is expressed in a modified smallpox virus vector (MVA).

In the study, which began in 2011, an adeno - associated virus vector was used to carry a functional copy of the affected gene to muscle cells in the diaphragms of nine patients.

«We think foamy virus vectors will be safer than other vectors being used for this disease,» Kiem said.

«Most scientists studying honey bees would rank Varroa mites and the viruses they vector to honey bees as, hands down, the number one killer of honey bees in the world.

The technique involves gene insertion by a virus vector and exposure to numerous regulatory proteins.

Several additional clinical trials testing different vaccine platforms including inactivated virus, DNA, mRNA, virus vector, and synthetic peptide vaccines are ongoing.

Adenovirus - associated virus vector - mediated gene transfer in hemophilia B. N Engl J Med 365 (25): 2357 - 65, 2011.

A simplified purification protocol for recombinant adeno - associated virus vectors.