Glycosaminoglycan - based hydrogels to modulate heterocellular communication in in
vitro angiogenesis models.
Interestingly, PDGF - BB overexpression by modified hDPSCs enhanced the recruitment of hDPSCs both in vitro and in vivo via the activation of the phosphatidylinositol 3 kinase (PI3K) / Akt signaling pathway and, in combination with secreted vascular endothelial growth factor (VEGF), enhanced in
vitro angiogenesis.
Growth differentiation factor - 15 (GDF - 15) suppresses in
vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2).
Not exact matches
In the past 10 years our laboratory has investigated the role of cell - matrix interaction in the control of endothelial cell functions in vivo and in
vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and / or down - regulation is beneficial in the setting of tumor associated
angiogenesis.
A method to assess target gene involvement in
angiogenesis in
vitro and in vivo using lentiviral vectors expressing shRNA.
Hepatocyte growth factor enhances vascular endothelial growth factor - induced
angiogenesis in
vitro and in vivo.
BME has also been employed in cell attachment, neurite outgrowth,
angiogenesis assays, in
vitro cell invasion and in vivo tumorigenicity assays.
Inhibition of cell proliferation and in
vitro markers of
angiogenesis by indole -3-carbinol, a major indole metabolite present in cruciferous vegetables.