Sentences with phrase «vitro model was used»
The in vitro model was used to extensively characterize the differences between neurons from different regions of the brain and to mimic the system's connectivity.
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Cellular and in vitro models were used in this study.
Not exact matches
These models can be used to explore the cellular role of PCSK9 in vitro and to test the efficacy of cholesterol - lowering agents.
Applying a new method that is used mainly in stem - cell research and regenerative medicine, researchers from the Technical University of Munich have now devised a robust intestinal model for molecular research into incretin release in a test tube (in vitro).
«With Teresa Woodruff's research using Draper's human organ system platform, we have a compelling demonstration of the importance of a microenvironment that permits cells to function in vitro as they would in vivo, and the power of being able to interconnect organ models on a platform and operate them in a stable and precise manner for weeks to months,» said Jeffrey T. Borenstein, a biomedical engineer at Draper.
Professor Alvaro Mata, from Queen Mary's School of Engineering and Materials Science, said: «The technique opens the possibility to design and create biological scenarios like complex and specific cell environments, which can be used in different fields such as tissue engineering by creating constructs that resemble tissues or in vitro models that can be used to test drugs in a more efficient manner.»
Currently I am involved in a very interesting project: The study of the network oscillations in the brain using an in - vitro animal model and a new high resolution microelectronic device.
Additionally, I am applying similar strategy to create the in vitro model of the inflammation in adipose tissue using iPS - derived adipocytes.
This approach is now being used to derive embryonic stem cells from a variety of strains including disease models from which in vitro tools are in demand, including mouse models of Alzheimer's disease, cytogenetic disorders (Turner's syndrome and Down syndrome), and tool strains for systems genetics.
Because they are derived from Cellartis hiPS cells, they sidestep the problems inherent to other currently used in vitro models to provide consistency and stability.
Overall, this simple technique (see figure for overview) produces therapeutically relevant cells in a safe and efficacious manner, which may be used in in vitro models for the investigation of glaucoma disease mechanisms, RGC development, drug testing, and may in the future lead to a treatment of glaucomatous neuropathy.
Gage has also developed an in vitro myelination model using iPSCs to be used for screening of pharmacological compounds and to better understand diseases such as schizophrenia and Parkinson's.
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
The test was developed using an in vitro gene - expression model.
Bushdid said in vitro models are gaining momentum in toxicology, which provides scientific analysis of potentially hazardous chemicals and investigates the toxic properties of new substances being used in consumer products and industrial settings.
«This in vitro model should give us the ability to assess a lot more compounds and agents at a reduced cost, with reduced animal use, and we should be able to do it faster,» said Bushdid, who is director of the Drug Development division's Toxicology & Pathology Services and discipline leader for the Developmental & Reproductive Toxicology (DART) program.
The new pH - Xtra Stress Test from Amsbio has been designed for use as a companion kit to their pH - Xtra Glycolysis Assay and contains all the additional components necessary for the evaluation of the glycolytic response of in vitro cell models to metabolic stress.
Therefore, it is very important to develop a suitable protocol to induce in vitro germ cell differentiation from monkey ES cells before non-human primate ES cells can be used as a model for in vitro differentiated germ cells.
We use this in vitro model of spontaneous tumorigenesis to generate a library of cell lines with 25 different de novo JAK1 - activating mutations, 6 of which are targeting two residues, Phe958 and Pro960, located in the hinge region at the periphery of the ATP - binding pocket.
Our group is using in vitro and vivo models to help study various pathogenic organisms to better understand the risk that they pose to the blood supply and to help develop vaccine and therapeutic options.
To demonstrate Amrose functionality in an established higher model system, Amrose v0 — v4 variants were cloned into the pCS2 + vector system to synthesize mRNA by in vitro transcription, which was used for injection into one - cell stage zebrafish embryos.
The success of such studies depends on which food fractions are studied, which phytochemicals are investigated, and which in vitro model of pathophysiology is used.
The study was done using an in vitro (i.e. «in glass» or test - tube) cell culture model of the small intestinal epithelium.
Next, seven of the 27 components (pantothenate, choline, nicotinamide, histidine, proline, pyridoxine and inositol) were retested using an in vitro trans - epidermal diffusion experimental model, providing a functional assessment of barrier properties (Watson et al. 2006).