Not exact matches
Testing each of these factors for their ability to return differentiated
tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated
tumor cells back into glioblastoma stem cells, both in
vitro and in an animal
model.
We use multiple mouse
models combined with in
vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within
tumors.
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse
Tumor Models, In
Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in
vitro and in vivo in numerous human
tumor cell lines and xenograft
models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.