Sentences with word «vivax»

The present study reports the Duffy blood group genotyping in P. vivax malaria patients from four different Brazilian endemic areas, exploring these significant phenotypic associations between blood group variants, as well as polymorphic regions of RBC receptors, with susceptibility or resistance to malaria.

It was demonstrated in individuals living in a malaria endemic region of Papua New Guinea that Duffy binding protein adherence to RBCs is significantly reduced for erythrocytes of P. vivax malaria patients who carry one Duffy - negative allele [15].

The findings are published in PLoS Medicine: Rosanas - Urgell A, Lin E, Manning L, Rarau P, Laman M, et al. (2012) Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case - Control Study.

Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development.

A recent study reports the whole genome sequencing of five P. vivax isolates taken directly from blood samples of infected patients in Cambodia and Madagascar, as well as the Belem strain that is adapted to survive in monkeys.

Each patient was found to be infected with multiple vivax strains.

The association of the Duffy blood group (FY) with P. vivax human malaria has been well - documented, where Duffy - negative individuals are naturally resistant to invasion by this parasite [2].

Duffy blood group polymorphisms are important in areas where Plasmodium vivax predominates, because this molecule acts as a receptor for this protozoan.

Previous studies have demonstrated that heterozygous Duffy negative malaria individuals remain susceptible to infections by P. vivax [13, 14].

«The major [biological] problems of Plasmodium falciparum [the cause of the worst form of malaria and the target of the RTS, S vaccine] have been solved, while vivax is more complex, and it has spread in practically all the world except Europe,» Ruth says.

However in 2011, 21 P. vivax cases from arriving immigrants were reported in the Southern agricultural area of Evrotas, along with 36 local cases.

P. ovale, P. cynomogli and P. vivax clearly share the same general topology of PIR architecture.

To identify orthologues, genes from the following eleven genome sequences were clustered using OrthoMCL28 (version 1.4): the present P. cynomolgi M, P. vivax P0129, P. falciparum 3D730, P. reichenowi CDC31, the re-annotated P. coatneyi, the rodent malaria parasites (P. yoelii, P. chabaudi and P. berghei32), P. knowlesi33, P. malariae and P. ovale curtisi34.

For example, in collaboration with James Dunford and Udo Oppermann at the University of Oxford, as well as Michael Arrowood at CDC and Eric Oldfield at U. of Illinois at Urbana Champain, we investigated the functions and structures of the C. parvum and P. vivax homologues of farnesyl pyrophosphate synthase, and found both parasite enzymes to produce different products from the human enzyme.

Mediated by this role, Sarah has established collaborations with researchers from a range of countries enabling the development of a network to support global P. vivax genetic epidemiology studies.

A more resistant Plasmodium facilparum organism (instead of the usual Plasmodium vivax variety) caused many of the new cases of the disease.

To further understand the duplication, we mapped the reads of P. cynomolgi, P. simiovale and P. vivax P01 against the locus on chromosome 9 containing the ancestral methyltransferase in P. cynomolgi (see Figure 5B).

These ties grew stronger in 2010 when Ruth and Victor started collaborating with Mauricio Rodrigues, an assistant professor in the Department of Microbiology, Immunology, and Parasitology at UNIFESP, working to develop a vaccine for a type of malaria produced by the parasite Plasmodium vivax, which affects an estimated 2.5 billion people.

Duffy blood group polymorphisms are important in areas where P. vivax predominates, because this molecule acts as a receptor for this protozoan (but not for the other human malaria parasites) on the surface of RBCs [19].

On the other hand, a previous study in the Western Brazilian Amazon region (Rondônia State) did not correlate Fy heterozygosity with protection against P. vivax [17].

The most serious forms of the disease are caused by Plasmodium falciparum and Plasmodium vivax, but other related species (Plasmodium ovale and Plasmodium malariae) can also infect humans.

We can thank our primate cousins not just for yellow fever but also for HIV, dengue fever, hepatitis B, and vivax malaria.

Victor is using the money to investigate the dormant phases of the Plasmodium (both falciparum and vivax) in the lab of Sergio Schenkman in the Department of Microbiology, Immunology, and Parasitology at UNIFESP.

Still, the two major human malaria parasite species, Plasmodium falciparum and P. vivax, are restricted in their «choice» of vertebrate host.

The goal is to rid the region of P. falciparum by 2025 and its milder relative P. vivax by 2030, for an estimated cost of $ 3 billion.

Together with Rodrigues, they submitted a patent for recombinant proteins that may be useful for a vivax malaria vaccine.

Two forms of malaria parasites were sequenced in the study; Plasmodium falciparum (responsible for up to 700,000 deaths per year) and Plasmodium vivax (responsible for 20 million infections per year).

The gene codes for an immune receptor on red blood cells; lack of that receptor prevents infection by Plasmodium vivax, a species of the malaria parasite.

Greece was declared malaria free in 1974, however, in 2011 a resurgence of P. vivax malaria was seen in Southern Greece in connection with the presence of agricultural workers from malaria - endemic regions in malaria receptive areas.

Despite these interventions 20 more introduced cases were reported in 2012 and, due to fears that the malaria parasite may be re-establishing in the area, a program of mass drug administration of one course of chloroquine and primaquine, which are the first line recommended antimalarials for P. vivax.

The word was «lone,» as in «PvPlm is the lone plasmepsin in the food vacuole of Plasmodium vivax.»

Plasmodium vivax is also particularly insidious because it can hide in the body for long periods of time without symptoms, causing disease relapses much later.»

The burden would have been even weightier, he adds, if the team had included Plasmodium vivax, the parasite that affects much of South Asia.

He's focused on the physiopathology of severe malaria in pregnant women and children, with a special interest in the identification of clinically relevant cytoadhesion phenotypes in P. falciparum and P. vivax, in the host and parasite molecules involved as well as in the targets of protective immune mechanisms.

The researchers, including Cleveland - based David Serre and Peter Zimmerman, Didier Menard (Institut Pasteur - Cambodia) and Arsene Ratsimbasoa (Madagascar National Malaria Control Program) are the first to sequence the genome of the parasite Plasmodium vivax, taken from patients at coverage needed to verify genome - wide DNA sequence variation.

As for the other clusters, it seems that the underlying structure of the pir genes predates the speciation of P. ovale, P. vivax and P. cynomolgi.

MSP - 3 is expanded in P. vivax, P. malariae, P. ovale and P. cynomolgi (see Figure 3B).

This updated number puts the P. cynomolgi pir gene repertoire at a similar size to that of P. vivax (1,216), while P. ovale curtisi has an even larger repertoire (1,949).

Three independent studies undertaken in Papua New Guinea revealed strong associations between the SAO genetic defect (SLC4A1Δ27) and protection against P. vivax malaria in infants and children.

Coverage plot mapped from P. cynomolgi reads (black), P. vivax (blue) and P. simiovale (magneta) is shown in log scale on P. cynomolgi.