Sentences with phrase «vivo cell systems»

To address these questions, we have established a variety of different in vitro and in vivo cell systems that allow us to dissect molecular mechanisms and function.

Not exact matches

This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors.

A microscope image shows many of the immune system's dendritic cells that were collected from a 3 - D scaffold three days after in vivo injection.

«With Teresa Woodruff's research using Draper's human organ system platform, we have a compelling demonstration of the importance of a microenvironment that permits cells to function in vitro as they would in vivo, and the power of being able to interconnect organ models on a platform and operate them in a stable and precise manner for weeks to months,» said Jeffrey T. Borenstein, a biomedical engineer at Draper.

After testing the system both in vitro and in vivo in an animal model, Scott's team demonstrated they could administer a subcutaneous injection that slowly delivered nanomaterials to cells in lymph nodes for over a month in a controlled fashion.

«An important, overarching goal of the field is to develop culture systems using primary cells with minimal ex vivo [external] manipulation.

While humanized mouse models provided a logical first approach to examine in vivo efficacy of CXCR4 disruption, this system does not make it possible to fully assess the functional impact of CXCR4 loss on CD4 + T cell function.

In this project, we aim to analyze the physiological and developmental functions of two metalloproteases acting at distinct surface regions of heart and muscle cells in the genetically accessible in vivo model system Drosophila.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3 - D ex vivo organ tissue.

This video provides an overview of MimEX ™ Tissue Model Systems, a next - generation 3 - dimensional (3 - D) cell culture platform for the generation of ex vivo epithelial - derived organ tissue.

Using Cultrex ® BME, MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3 - D ex vivo organ tissue.

With this information, they turned to a cell culture system to see if any Cpf1 nucleases would exhibit in vivo activity in mammalian cells.

For this purpose, we have generated transgenic lines that monitor in vivo and in real - time the proliferation of β - cells using the FUCCI (Fluorescent Ubiquitination - based Cell Cycle Indicator) system.

We will mine and exploit information from studies and screens in model organisms, but our primary focus is on the paradigmatic mammalian stem cell systems - haematopoiesis and epithelia in vivo, and embryonic and neural stem cells in vitro.

Expression profiling of fungi and the mammalian host during in vivo infections and ex vivo infections of culture immune system cells

ViaCyte is engineering the Encaptra ® cell delivery system to enable implanted PEC - 01 ™ cells to survive and thrive in vivo and to differentiate into functional insulin - producing cells.

Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue - specific stem cells, stem cell differentiation, epigenetics, stem cell genomics and systems biology, genome reprogramming, cancer stem cells, stem cell niches, stem - cell - based disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging of stem cells, therapeutic applications, regenerative medicine, clinical and translational insights, stem cell research policies, ethical issues, and technical or resource - based innovations.

We work exclusively in the human system, mostly with primary cells and tissue, with a constant concern of recreating conditions that mimic the in situ and in vivo settings.

ZVex ® and GLAAS ™ are our complementary discovery platforms designed to activate and expand the immune system's natural ability to create tumor - specific cytotoxic T cells (CTLs) in vivo.

From numerous studies in the Xenopus paired oocyte system and various cell culture systems, a reasonable assumption might be that if two cells express the same connexin or innexin and lie in close membrane apposition, gap junctions will probably be established between them; this assumption has not been investigated rigorously in vivo.

Our goal is to create a microfluidic 3D cell culture system representing a «placenta - on - a-chip» in order to mimic the nutrient / waste transfer between maternal blood and fetal blood that occurs in the cotyledon section of the placenta, and to test and observe the effects of ethanol within the maternal bloodstream and compare it to a similar in vivo situation.

«Both [the] in vivo and in vitro experiments have shown striking anticancer effects... demonstrated that phytate is a broad - spectrum antineoplastic agent,» meaning antitumor agent across different cells and tissue systems.