Finally, the
functional inactivation of our target gene by one identified pharmaceutical agent will be
tested in DM1 mouse model in order to monitor its ability to impact in
vivo on DM1 molecular and physiological features.
To
test the
functional properties of these distinct astrocyte populations in
vivo, hGDAsBMP, hGDAsCNTF or undifferentiated hGPCs were transplanted into the injury site of adult Sprague - Dawley rats that had received unilateral transections of the right - side dorso - lateral funiculus (DLF), including the rubrospinal pathway, at the C3 / C4 intervertebral spinal cord level.
These results indicate the importance of assessing miR function in the complex physiology of in
vivo model systems and indicate that further
functional testing of miR - 342 is required before concluding it is a bona fide tumor - suppressor - miR.
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