Sentences with phrase «vivo microdialysis»

Stable isotope labeled L - kynurenine (KYN) metabolism investigated using In vivo microdialysis coupled with a novel high content LC / MS / MS method D. P. BUDAC, D. SONG, M. CAJINA, A. LEE, B. M. CAMPBELL, G. LI, C. SÁNCHEZ, C. FORRAY, V. S. PALAMARCHOUK, G. N. SMAGIN... Abstract / Posters

Early in his career he developed a method for quantitative in vivo microdialysis where he showed that a measure of in vivo neurotransmitter recovery (or the «extraction fraction») is a viable index of clearance rates that has proven useful for the characterization of drug - or genetically induced alterations in neurotransmitter turnover.

Through the combined use of in vivo microdialysis and behavioral and neuropharmacological techniques, his early work characterized the role of serotonin and its signaling via serotonin - 1B (5 - HT1B) receptors in the ventral tegmental area, nucleus accumbens, and ventral pallidum in the rewarding actions of cocaine and ethanol.

Using a combination of behavioral techniques, pharmacological manipulations, and in vivo microdialysis, he also demonstrated that endocannabinoids influence drug reward through the CB1 receptor - mediated modulation of dopamine, GABA, and glutamate signaling in the mesocorticolimbic and striatopallidal circuits.

Not exact matches

He developed an innovative microdialysis approach that allows the in vivo sampling of lipid signaling molecules in the brain (including endocannabinoids) and has demonstrated that voluntary self - administration of ethanol, heroin, and cocaine produces distinct drug - and region - specific changes in brain endocannabinoid levels.