Post surgery, there is a major risk of
vocal cord tissue regrowth, or «webbing» which can lead to future respiratory problems.
December 7, 2015 — Researchers grew human cells into functional
vocal cord tissue in the laboratory — an important preliminary step toward restoring voice function to people with injured vocal cords.
For the study, the researchers first collected
vocal cord tissue from four people who had their larynges removed for unrelated reasons, and from one human cadaver.
In about two weeks, the cells grew together and formed a tissue that «felt like
vocal cord tissue,» Welham said in a statement.
To see if the engineered
vocal cord tissue could generate sound, the investigators transplanted the tissue into larynges that had been taken from dogs, which are anatomically similar to human larynges.
However, this is not surprising, because
vocal cord tissue normally takes time to mature, the researchers said.
Researchers have grown
vocal cord tissue in the lab, and it works — the tissue was able to produce sound when it was transplanted into intact voice boxes from animals, according to a new study.
The researchers also looked at whether the engineered
vocal cord tissue would be rejected or accepted by mice that had been engineered to have humanlike immune systems.
The scientists then put the engineered
vocal cord tissue to the test.
For the first time, scientists have created
vocal cord tissue starting with cells from human vocal cords.
The research team started with
vocal cord tissue from a cadaver and from four patients who had their voice boxes removed.
Not exact matches
They took cells from those
tissue samples and successfully grew them on a three - dimensional scaffold to produce new
vocal cords.
One of the major next steps would be placing the engineered
tissue in the
vocal cords of living animal models and having it survive and work.
Scientists implanted the engineered
tissue (lighter color on bottom
vocal cord) in cadaver dog larynges to test how well it vibrated and produced sound.
«These tumors have a denser blood supply than the underlying
vocal -
cord tissue, preservation of which is necessary to retain optimal
vocal quality.
These include a hypoplastic trachea (a malformation of the tracheal cartilage rings leading to narrowing of the airway), stenotic nares (which means the nostrils are pinched and narrow), everted laryngeal saccules (a condition where the soft
tissue located in front of the
vocal cords becomes swollen and inflamed) and an elongated soft palate, all of which can contribute to increased respiratory effort and noise.
It involves removing some
tissue from the dog's
vocal cords.
A surgery to remove the
tissue of the
vocal cords may in fact reduce the noise level of the bark, but it does nothing to address the behavioral issue underlying the excessive barking.
Surgical canine debarking can be performed by removing the
tissues from the sides of the
vocal cord or larynx, resulting in a reduced pitch and decreased level of the barking sound.
This can be done either by an approach from the mouth or by making an incision at the throat and then removing
tissues from the
vocal cord.
Everted Laryngeal Saccules (Figure 4) is a condition in which
tissue within the airway, just in front of the
vocal cords, is pulled into the trachea (windpipe) and partially obstructs airflow.