Sentences with word «vorinostat»

Future studies are needed to assess the effect of vorinostat in broader transplant settings.

This spring, a clinical trial will start at the Alberta Children's Hospital exploring the clinical efficacy of vorinostat in children who have failed to respond to current anti-seizure medications.

Trial # 5: Combined autophagy and HDAC inhibition: A phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of HCQ in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumor.

The study, the first to test this treatment in people, combined the drug vorinostat with standard medications given after transplant, resulting in 22 percent of patients developing graft - vs.

The researchers found vorinostat was safe and tolerable to give to this vulnerable population, with manageable side effects.

«Only vorinostat and belinostat always induced the BIM protein, always induced cell death, and always showed synergy with paclitaxel,» Marlow says.

Specifically, vorinostat targets histone deacetylases, which are different from the usual molecules targeted by traditional treatments.

We are currently investigating vorinostat plus standard therapies to prevent GVHD in transplants with an unrelated donor.»

They also received vorinostat, which is given as a pill taken orally.

«Vorinostat combined with standard graft - vs.

During a withdrawal period of 24 hours, one alcohol - exposed group was treated with an FDA - approved HDAC inhibitor called suberoylanilide hydroxamine (SAHA), also known as Vorinostat, followed by anxiety and epigenetic measures.

After vorinostat, they remembered.

The team believes pairing a latency reversing agent, like Vorinostat, with an antiviral immune therapy, such as a vaccine or an antibody capable of recognizing and clearing the latent cells, will be needed to achieve a cure.

The team studied Vorinostat in 16 patients living with HIV whose viral load was controlled through standard antiviral therapy.

She is managing a trial exploring a promising avenue — giving people a cancer drug called vorinostat that «wakes up the virus» so it can be destroyed with antiretroviral drugs.

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.

Fifty of the 61 participants completed the full 21 - day course of vorinostat.

By screening commercially available drugs currently being used for other diseases, researchers found vorinostat to be an effective anti-seizure drug in zebrafish and mouse models.

Using cancer drug vorinostat, Kennedy believes he can boost the one working copy of TCF4 to compensate for the damaged copy — like turning up the radio when it has one broken speaker.

And, there were two agents in their study that did that: vorinostat and belinostat.

One of the more intriguing findings in the study was that increasing histone crotonylation works synergistically with other known anti-HIV latency molecules, such as the protein kinase C agonist PEP005 and the HDAC inhibitor vorinostat.

«Vorinostat has a dual effect as an anti-cancer and an anti-inflammatory agent.

Vorinostat is currently approved by the U.S. Food and Drug Administration to treat certain types of cancer.

«We tested a drug currently used for cancer treatment (vorinostat (Zolinza)-RRB- and found that it reduced average daily seizures in zebrafish and mouse models by 60 per cent,» says Kurrasch.

HBI — through their Translational Research Fund — is the primary sponsor of the vorinostat clinical trial, with supplementary funding from ACHRI.

Five years ago, he enrolled in a study at the UNC School of Medicine, which was part of Dr. David Margolis» «kick and kill» strategy for eradicating HIV by flushing it out of hiding with a drug called Vorinostat and killing it with either a vaccine or with immunotherapies.

Five years ago, he enrolled in a study at the UNC School of Medicine, which was part of Dr. David Margolis» «kick and kill» strategy for eradicating HIV by flushing it out of hiding with a drug called Vorinostat and killing it with either a vaccine

He's also looking at other drugs that can do the same thing without the side effects of vorinostat, which has all the problems associated with chemotherapy.

After being given the drug vorinostat, they remembered the location, giving researchers hope the drug may not only help Pitt Hopkins sufferers, but other memory - related afflictions including Alzheimer's.

Romidepsin (Istodax) and vorinostat (Zolinza) inhibit enzymes called histone deacetylases (HDACs) that tighten the coil around DNA and block expression of tumor suppressor genes.

«We showed that a single dose of Vorinostat could expose the hidden virus several years ago, but it has taken two studies over the last five years to define the proper interval dosing strategy to use Vorinostat safely and effectively,» said Nancie Archin Ph.D., lead author of this study and an assistant professor in the Division of Infectious Diseases at UNC.

The synthetic triterpenoid, 2 - cyano - 3, 12 - dioxooleana - 1, 9 (11)- dien -28-oic acid (CDDO - Me), prevented tumor development in models of estrogen receptor - negative breast cancer, pancreas cancer and lung cancer either alone or in combination with vorinostat or rexinoids (Tran et al 2013).