Sentences with phrase «vorinostat in»

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.

The team studied Vorinostat in 16 patients living with HIV whose viral load was controlled through standard antiviral therapy.

This spring, a clinical trial will start at the Alberta Children's Hospital exploring the clinical efficacy of vorinostat in children who have failed to respond to current anti-seizure medications.

A phase I clinical trial conducted by investigators at the University of Texas San Antonio, showed that the combination of HCQ and the chemotherapy drug vorinostat in 27 patients with advanced solid tumors, including renal cell carcinoma and colon cancer, was clinically safe and inhibited autophagy.

Not exact matches

One of the more intriguing findings in the study was that increasing histone crotonylation works synergistically with other known anti-HIV latency molecules, such as the protein kinase C agonist PEP005 and the HDAC inhibitor vorinostat.

We are currently investigating vorinostat plus standard therapies to prevent GVHD in transplants with an unrelated donor.»

«We tested a drug currently used for cancer treatment (vorinostat (Zolinza)-RRB- and found that it reduced average daily seizures in zebrafish and mouse models by 60 per cent,» says Kurrasch.

By screening commercially available drugs currently being used for other diseases, researchers found vorinostat to be an effective anti-seizure drug in zebrafish and mouse models.

Five years ago, he enrolled in a study at the UNC School of Medicine, which was part of Dr. David Margolis» «kick and kill» strategy for eradicating HIV by flushing it out of hiding with a drug called Vorinostat and killing it with either a vaccine

Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma

«We showed that a single dose of Vorinostat could expose the hidden virus several years ago, but it has taken two studies over the last five years to define the proper interval dosing strategy to use Vorinostat safely and effectively,» said Nancie Archin Ph.D., lead author of this study and an assistant professor in the Division of Infectious Diseases at UNC.