Sentences with phrase «vorinostat with»
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One of the more intriguing findings in the study was that increasing histone crotonylation works synergistically with other known anti-HIV latency molecules, such as the protein kinase C agonist PEP005 and the HDAC inhibitor vorinostat.
https://www.sciencedaily.com/
A phase I clinical trial conducted by investigators at the University of Texas San Antonio, showed that the combination of HCQ and the chemotherapy drug vorinostat in 27 patients with advanced solid tumors, including renal cell carcinoma and colon cancer, was clinically safe and inhibited autophagy.
She is managing a trial exploring a promising avenue — giving people a cancer drug called vorinostat that «wakes up the virus» so it can be destroyed with antiretroviral drugs.
We are currently investigating vorinostat plus standard therapies to prevent GVHD in transplants with an unrelated donor.»
«Vorinostat combined with standard graft - vs.
During a withdrawal period of 24 hours, one alcohol - exposed group was treated with an FDA - approved HDAC inhibitor called suberoylanilide hydroxamine (SAHA), also known as Vorinostat, followed by anxiety and epigenetic measures.
HBI — through their Translational Research Fund — is the primary sponsor of the vorinostat clinical trial, with supplementary funding from ACHRI.
Five years ago, he enrolled in a study at the UNC School of Medicine, which was part of Dr. David Margolis» «kick and kill» strategy for eradicating HIV by flushing it out of hiding with a drug called Vorinostat and killing it with either a vaccine
Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma
The team believes pairing a latency reversing agent, like Vorinostat, with an antiviral immune therapy, such as a vaccine or an antibody capable of recognizing and clearing the latent cells, will be needed to achieve a cure.
The team studied Vorinostat in 16 patients living with HIV whose viral load was controlled through standard antiviral therapy.
Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.