Atrial fibrillation (AF) is a strong independent risk factor for ischemic stroke.1, 2 Vitamin K antagonist (eg, warfarin) treatment reduces the risk of stroke by 64 % and all - cause mortality by 26 %, compared with control in patients with AF.3 However,
warfarin confers an increased risk of hemorrhage, with intracranial bleeding the most severe effect.4 - 7