Sentences with phrase «water maze»

Day 1 of the two - day water maze procedure involved training the mice to find the platform using cues located around the pool within a 180 s time frame.

Mice were administered the Morris water maze test in an opaque pool with a submerged platform, and humans were administered a virtual version in a circular field with a buried treasure using a 30 - in.

Streptozotocin - diabetic rats express deficits in water maze learning and hippocampal synaptic plasticity.

This video will summarize principles of Morris Water Maze testing review procedures for setting up and running the test and highlight some ways that this and other water tests are used in lab studies.

Mice with a disabled RGS14 gene remembered objects in their cages more easily and learned to navigate water mazes better, pharmacologist John Hepler and his colleagues found. Since the presence of a functional RGS14 gene holds mice back mentally, Hepler and his colleagues have been jokingly calling it «the Homer Simpson gene.»

When the pups get older, they will learn to paddle through water mazes or bury black marbles in their bedding, giving researchers insight into how their memory and behavior compare with that of typical mice.

A High Fructose Diet Does Not Affect Amphetamine Self - Administration or Spatial Water Maze Learning and Memory in Female Rats.

The study compared the performance of normal and Alzheimer's disease (AD) model mice on the Morris water maze with the performance of healthy control subjects and early - stage AD patients on a video game version of the task.

Bruggeman, E.C., Li, C., Ross, A.P., Doherty, J.M., Williams, B.F., Frantz, K.J., Parent, M.B. (2011) A high fructose diet does not affect amphetamine self - administration or spatial water maze learning and memory in female rats.

(A) The two - day water maze analyzes spatial navigational memory.

They compared the animals» ability to negotiate a radial - arm water maze, a standard test of cognitive ability, with that of regular J20 mice and of normal mice at 4, 9, and 14 months of age.

When the researchers genetically inhibited RbAp48 in the brains of healthy young mice, they found the same memory loss as in aged mice, as measured by novel object recognition and water maze memory tests.

Results from this two - day water maze show that AD mice take considerably longer to find the hidden platform on Day 2 than AD mice treated with J147 for three months (Figure 1A), demonstrating that J147 significantly improved the spatial navigational memory in aged, transgenic AD mice.

Spatial memory is assessed using the Morris Water Maze [100] and hippocampal - dependent associated memory is analyzed by using a fear conditioning assay [101].

Next, mice were observed in the two - day water maze behavioral assay which involves training mice on Day 1 with a visible platform and visual cues and hiding the platform on Day 2.

Previous adaptations of the Morris water maze for humans varied significantly from the original in their design and performance measures.

Use of an Eight - arm Radial Water Maze to Assess Working and Reference Memory Following Neonatal Brain Injury

Dissociation between Performances in Water Maze and Spontaneous Alternation in BALB / C versus A / J Mice

The mice forget how to navigate water mazes they had mastered; they don't recognize signs of imminent danger they had once responded to fearfully.

The research was done with laboratory mice that consumed different diets and then faced a variety of tests, such as water maze testing, to monitor changes in their mental and physical function, and associated impacts on various types of bacteria.

«The Honeycomb Maze replicates all the advantages of the justly - famous Morris Water Maze in that it forces the animal to approach a hidden goal from different directions, ruling out non-hippocampal-dependent strategies.

The two - day water maze analyzes spatial navigational memory [12], which is impaired in huAPP / PS1 mice when compared to wild type littermates [10, 32].

Spatial memory was determined using the two - day water maze in 23 - month - old huAPPswe / PS1 transgenic mice fed J147 at 200 ppm in food for the previous three months.

Water maze learning and hippocampal synaptic plasticity in streptozotocin - diabetic rats: effects of insulin treatment.

For example, after receiving THC, young mice took longer to learn where a safe platform was hidden in a water maze, and they had a harder time recognizing another mouse to which they had previously been exposed.

This intellectual boost was demonstrated by the enhanced performance of the mice during tests requiring them to navigate a water maze and distinguish between known and unknown objects.

First she deprived juveniles of vision in one eye so that the corresponding brain cells failed to make connections; once the mice reached maturity, they were put in a water maze that required them to recognize a pattern of fine lines to find a floating platform.

«They're in a germ - free facility,» she says apologetically, glancing away from a video in which a tiny champion powers through a water maze.

Subsequent analyses of the brains of these animals revealed that the drug reduced the plaques and tangles in the hippocampus, which is known to play a key role in learning the water maze, but not in the amygdala, which figures importantly in the dark chamber test.

They sent each mouse through a water maze that required it to find a platform obscured beneath the surface of murky water.

Mice bred to have a malfunctioning form of CREB, Silva's study demonstrated, did not remember from one day to the next that they had already been taught to navigate a water maze or that they had previously been placed in a special cage where they received a mild electric shock.

But the strongest evidence of the treatment's success came when treated mice were put in the centre of a water maze with six possible corridors, only one of which led to a ledge that the mice could clamber out of the water onto.

Compared to control mice, older animals with no B2M were better at learning and memory tasks, nearly as good as young animals at completing the water maze, for instance, the scientists report online today in Nature Medicine.

Afterward, the animals had trouble navigating a water maze.

When the researchers injected B2M into 3 - month - old mice, the young animals suddenly had trouble remembering how to complete a water maze, making more than twice as many errors after they'd already been trained to navigate the maze.

The mice had to swim to a platform in a memory task called a Morris Water Maze.

One effect, not surprisingly, is that the rats become very poor at tasks requiring internal map - making skills, such as remembering the location of a resting platform in a water maze test.

The mutant mice had difficulty learning and remembering the location of a hidden platform in a water maze, which ordinary mice accomplish with ease.

Indeed, when mice lacking the gene for making IL - 4 take the water maze test, they do badly, perhaps because their T cells lack a critical signal involved in fast learning.

In a paper appearing online this week in the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal mice.

When those animals were put into a water maze, they, too, performed badly — just as Kipnis had predicted.

Cohen subjected the mice to a learning test known as the Morris water maze.

The mice then had to find a submerged platform in a water maze using visual cues.

An experimental chemical that blocked its action created temporary geniuses: Mice on it were whizzes in the Morris water maze.

The mice administered MW108 found the resting platform in the water maze as quickly as a control group of mice.

Next, each group of mice was taught environmental cues to learn how to swim through a water maze to find a resting platform.

After 4 weeks of rest, Rosi trained the mice to swim through a water maze, where they used cues to remember the location of a hidden resting platform.

(The enriched environment included being caged with other rats and having access to water mazes, exercise wheels and other environmental stimuli.)