Sentences with phrase «week old mice»

(A) 2 × 106 HPCs were transplanted in sublethally irradiated MRL, Rag2 − / − γc − / − or 129SvJ 8 — 12 week old mice.

Not exact matches

The researchers conducted a series of micromanipulations on the eggs of mice between the ages of 6 and 12 weeks (young) and 60 - week - old mice (old).

The researchers studied mice engineered to develop plaques in their brains when the animals are about 10 weeks old.

This slice of retina came from a three - week - old mouse.

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

After 4 weeks of connection to young mice, the five old mice's heart tissue had thinned and softened, looking just as spry and supple as the 2 - month - olds».

In these genetically modified mice, plaques first appear at about 6 weeks old.

Investigators (Fumitaka Sato, PhD, et al) tested resveratrol in autoimmune and viral models of MS.. In the autoimmune model, experimental autoimmune encephalomyelitis (EAE) was induced in 6 - week - old mice using myelin oligodendrocyte glycoprotein (MOG) 35 - 55 peptide.

This report shows, however, that after only eight weeks of exercise, old mice experienced faster muscle repair and regained more muscle mass than those of the same age that had not exercised.

In the first group, old mice were trained three days / week for eight weeks.

GREEN GLOB - LINS Spurred by a dose of misfolded proteins, a 20 - week - old mouse developed clumps of deformed proteins (green) in a cluster of cells called an islet (red) in its pancreas.

After the final stressors were administered, the researchers gave the young mice a round of behavioral tests and then waited until the mice reached adulthood, at about 10 weeks old, to see if their different upbringings had affected their cognitive abilities or brain morphology.

By the time the mice were 3 weeks old, the researchers found that their intestines were indeed as leaky as those of mice that had been treated with a chemical that induces colitis.

When the research team gave old mice — the equivalent of 70 - to 80 - year - old humans — water containing an antioxidant known as MitoQ for four weeks, their arteries functioned as well as the arteries of mice with an equivalent human age of just 25 to 35 years.

To investigate, Chen and his colleagues tested a group of five - week - old mice, with two weeks of voluntary wheel running.

It wasn't a complete cure, but injected mice could still hear very loud sounds when they were 8 weeks old, unlike uninjected mice (Nature, doi.org/chnx).

By the time they were 4 weeks old, the C - section mice had lower levels of some bacterial species and more of others.

The researchers bred mice deficient for the protein — called placental growth factor (PlGF)-- and broke their tibias under anesthesia when they were 11 weeks old.

To test whether adipose tissue F4 / 80 + cells shared a common bone marrow origin with other tissue macrophage populations, we transplanted bone marrow from C57BL / 6J mice expressing the CD45.1 leukocyte marker into 6 - week - old lethally irradiated C57BL / 6J mice expressing the CD45.2 leukocyte marker.

We examined six experimental groups of 20 - week - old C57BL / 6J mice: (a) lean C57BL / 6J female mice, (b) lean C57BL / 6J male mice, (c) moderately obese C57BL / 6J male mice with diet - induced obesity, (d) moderately obese female B6.Cg Ay / + mice, (e) severely obese female B6.V Lepob / ob mice, and (f) severely obese male B6.V Lepob / ob mice.

The scientists infected 1 - day - old C57BL / 6 mice with Zika virus and found that they develop symptoms of neurological disease, such as unsteady gait and seizures that gradually fade over two weeks.

NSG (NOD.Cg - PrkdcscidIl2rgtm1Wjl / Szj) mice, 8 — 9 weeks old at time of initial injection, were derived from breeders purchased from The Jackson Laboratory (Bar Harbor, ME).

Six - week - old male CD45.2 + (C57BL / 6J) recipient mice and syngeneic CD45.1 + (B6.SJL Ptprca Pep3b / BoyJ) donor mice were purchased from The Jackson Laboratory.

A 36 - hour coculture of aged HSCs (from 18 - 24 month - old mice) with young MSCs (from 6 - 8 week - old mice) reversed signs of aging in HSCs

Male or female (5 - 6 wks old) wild type and genetically modified mice (as required for individual investigator's protocols) will be fed a high fat high sucrose diet (from Research Diets ranging in fat from 45 - 58 % of calories as fat, 26 - 39 % carbohydrate (sucrose) and 16 % protein or control diets (10 % fat, 73 % carbohydrate, 16.4 % protein or rodent chow) for up to 16 weeks.

Animals were maintained on the C57BL / 6 background and 8 — 10 - week - old mice of both genders were used if not otherwise indicated.

Tanzi and Moir worked with youthful, four - week - old mice, which were a long way from developing amyloid - beta plaques.

One - month - old wild - type (n = 6) and p21 - null (n = 18) female mice were irradiated (+ IR) weekly for 4 weeks with 1.75 Gy.

One hundred twenty BALBC mice age 7 - 8 weeks old were purchased from the experimental laboratory of «Theiageneio «Anticancer Hospital, and were divided in six groups.

For γ - radiation tumorigenesis, 1 - month - old mice were irradiated weekly for 4 weeks with a 1.75 - Gy dose from a 137Cs source (MARK 1 - 30 Irradiator; Shepherd & Associates) at a rate of 1.14 Gy / min.

Behavior experiments reported here and time course experiments involved male BALB / c mice all 9 weeks old, ordered from The Jackson Laboratory, 10 mice per group.

Four - to six - week - old female mice were used for tumor injections.

(a) Neonatal chimeric mice, (b) two - week old chimeric mice.

Two - to 3 - month - old wild - type mice were randomized to sedentary or exercise groups for three to four weeks (A).

To further verify their incorporation into host organs, we sacrificed two - week old chimeric mice.

Adult mice (C57BL / 6J, 8 weeks old) were anesthetized, and then perfused with 4 % paraformaldehyde (PFA).

All mice used were C57BL / 6J, 8 to 10 weeks old and group housed.

To test the hypothesis that exercise could increase brain progranulin levels in Grn + / − mice, we solo - housed 6 - month - old wild - type (Grn + / +), Grn + / −, and Grn − / − mice in standard mouse cages or cages with running wheels for 7.5 weeks.

We tested this hypothesis by housing 2 - month - old wild - type mice with or without running wheels for 3 — 4 weeks.

We therefore tested 4 - to 8 - month - old Grn + / − mice with 4 weeks of wheel running (Fig. 4A), a time period that was previously reported to increase progranulin in wild - type mice (Asakura et al., 2011).

Female 7 - week old nude - beige - xid mice (NCI) were injected with MCF7 / HER2 cells (5 × 106) in the right mammary fat pad.

Four weeks - old patDp / + mice develop a low bone mass phenotype in the appendicular but not the axial skeleton compared to the littermate controls.

Female 13 and 52 weeks old tg2576 and APP / PS1 mice were investigated using SmartCube ™ (spontaneous behavior), NeuroCube ™ (Measurement of gait and motor function) and the PhenoCube ™ (social interaction, day / night activity and cognition) Systems.

For that purpose, 21 - to 23 - month - old mice were treated with daily injections of either recombinant GDF11 (rGDF11, 0.1 mg / kg mouse body weight), a dosing regimen that increases GDF11 levels in old mice toward youthful levels (13), or phosphate - buffered saline (PBS)(vehicle) for 4 weeks, and their blood vessels were subsequently analyzed by using the volumetric assay described above.

CD4 + and CD8 + Teffs were prepared from spleens of 8 - and 11 - week - old female Balb / c, NOD, NOR, and C57BL / 6 mice (Jackson Laboratories, Bar Harbor, ME), as previously described (7).

They gave some 18 week old male mice a diet with either low (4 - 7 %) or high (18 %) protein intakes.

While young mice (18 weeks, equivalent to young adults) lost only a few percent of body weight on the starvation low protein diets, elderly mice (2 years old) wasted away on low protein diets.

Eighteen - week - old male C57BL / 6 mice were fed continuously for 39 days with experimental, isocaloric diets designed to provide either a high (18 %) or a low (4 % — 7 %) amount of calories derived from protein...

The authors found that «one week of treatment with a compound that boosts NAD + levels is sufficient to restore the mitochondrial homeostasis and key biochemical markers of muscle health in a 22 month old mouse to levels similar to a 6 month old mouse.

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