«There's no reason in my mind to think that we're not going to have iPS cells that function as
well as embryonic stem cells».
Not exact matches
Using a mathematical model known
as the Ising model, invented to describe phase transitions in statistical physics, such
as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human
cell types, including normal and cancerous colon, lung and liver
cells,
as well as brain, skin, blood and
embryonic stem cells.
Base oxidation regulates gene activity In cooperation with colleagues at LMU,
as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in
embryonic stem cells of mice.
Freed expects transplants of neurons derived from
embryonic stem cells to enter the clinical arena soon
as well.
Furthermore, they have found that neural
stems cells can be culled from the patient's bone marrow, thus circumventing ethical and political obstacles to neural
stem cell therapy
as well as problems with immune rejection that sometimes arise when researchers must employ
embryonic stem cell lines.
In the U.S.,
as well as in Germany and the UK, first results with adult
stem cells suggest that they are at least equivalent to
embryonic stem cells.
• News of
Embryonic Stem Cells • A University of Wisconsin team used human embryonic cells to form cells that manufacture platelets as well as red and white blo
Embryonic Stem Cells • A University of Wisconsin team used human embryonic cells to form cells that manufacture platelets as well as red and white blood c
Cells • A University of Wisconsin team used human
embryonic cells to form cells that manufacture platelets as well as red and white blo
embryonic cells to form cells that manufacture platelets as well as red and white blood c
cells to form
cells that manufacture platelets as well as red and white blood c
cells that manufacture platelets
as well as red and white blood
cellscells.
But if homologous recombination could be worked out in human (
embryonic)
stem cells, then cardiomyocytes with mutations in ion channels could be derived,
as well as a large number of other very useful disease models of other tissues.
If it is proved that iPS
cells are
as good as or
better than
embryonic stem cells, I think they can replace them.
The researchers confirmed Olig2's role in promoting motor neuron formation by increasing or blocking the function of Olig2 in the spinal cords of developing mouse and chicken embryos,
as well as during motor neuron formation in mouse
embryonic stem cells.
The only
stem cell research he would permit, Bush said, was research using existing
embryonic lines
as well as so - called adult
stem cells, which occur in anyone of any age.
When the researchers added a specific bone morphogenetic protein called BMP4,
as well as another signaling molecule called retinoic acid, to human
embryonic stem cells, they got a mixture of two types of sensory interneurons.
Human
embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD),
as well as the conversion of somatic
cells, such
as skin fibroblasts, into induced pluripotent
stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific
cell models.
\ n I know it may be a long time before we reach consensus on the morality of the
embryonic stem cell question
as well as the closely related questions of abortion and IVF.
It will appeal to those interested in adult
stem cells as well as those interested in
embryonic stem cells.
This two - volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and
embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize
stem cells and progenitor populations,
as well as a presentation by the world's experts of what is currently known about each specific organ system.
«The current extension of induced pluripotency to human
cells is a major development and although it is early days for this technique it may
well prove to be every bit
as signifcant
as the first derivation of human
embryonic stem cells nine years ago.
«This discovery will advance our understanding of
stem cell epigenetics and chromatin structures, provide potential mechanisms on maintaining the hallmark properties of ES
cells, and help researchers with the rich source of information to
better understand some of the unique features — such
as self - renewal and pluripotency — of human
embryonic stem cells,» said Ng Huck Hui, Ph.D., senior group leader at GIS and a member of the Singapore team that conducted this research.
The challenge takes on even more urgency with recent developments, including a federal administration now more open to exploring the potential of
stem cells, the recent FDA approval of a human trial involving
embryonic stem cells,
as well as the reported case of a young boy who developed a brain tumor four years after receiving a
stem -
cell treatment for a rare genetic disorder.
Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human
embryonic stem cells, stromal
cells, haematopoietic
stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases
as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters
Patient - specific
stem cells may offer an alternative to
embryonic stem cells that will skirt the need for immunosuppressive therapy
as well as the social and political ramifications of
embryonic stem cell research, but their utility extends far beyond such groundbreaking advances and will assist future clinical practice and patient care.
A UCLA ophthalmologist injected each woman with 50,000 retinal
cells derived from human
embryonic stem cells, and according to the paper, both claim to have
better vision
as a result.
As you know, embryonic stem cells have the potential to be used to treat and better understand deadly and disabling diseases and conditions that affect more than 100 million Americans, such as cancer, heart disease, diabetes, Parkinson's, Alzheimer's, multiple sclerosis, spinal cord injury, and many other
As you know,
embryonic stem cells have the potential to be used to treat and
better understand deadly and disabling diseases and conditions that affect more than 100 million Americans, such
as cancer, heart disease, diabetes, Parkinson's, Alzheimer's, multiple sclerosis, spinal cord injury, and many other
as cancer, heart disease, diabetes, Parkinson's, Alzheimer's, multiple sclerosis, spinal cord injury, and many others.