Sentences with phrase «well as transcription factors»

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

hGDAsCNTF also expressed high levels of neurite - outgrowth inhibitory chondroitin sulfate proteoglycans, phosphacan and CSPG4, as well as the transcription factor Olig2 - all of which have been found to be upregulated in glial scar associated astrocytes.

Not exact matches

Demonstrating Cpf1's noticeable specificity, another research team from the same IBS Center succeeded in bringing Cpf1 RNP - mediated mutations into mouse embryos: The researchers targeted Foxn1 (a transcription factor that regulates the immune system, including the growth of skin hairs), as well as Tyrosinase (an enzyme that catalyzes the production of melanin, a natural pigment that determines the color of skin).

Transcription factors play a pivotal role in many illnesses, including cancer as well as many hereditary diseases.

First author Adam Skibinski, M.D. / Ph.D., student at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University, said «We've known for a long time that breast cells can lose their normal identity when they become cancerous, but we are now realizing that normal cells can change their characteristics as well in response to transcription factors like TAZ.

The transcription factor Gcn4 is conserved in over 50 different organisms, including mammals, and it likely play a significant role in the aging of these organisms as well.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

The new consortium proposes to characterize and tag the 1486 known transcription factors — proteins that switch genes on and off — in the mouse genome, as well as an estimated 600 coregulators that chip in to control cellular and biological functions through networks called regulons.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track - record of publications in peer - reviewed journals; solid experience in the biochemistry of complex DNA - binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous expression systems as well as their characterization using functional studies such as by isothermal titration calorimetry fluorescence, transcription assays.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

ALFA compiles the current state - of - art about the annotations of DNA regulatory elements (such as transcription factor binding sites, microRNA target sites) for a better understanding of biological processes underlying rare diseases.

Knockdown of Nrf2 expression resulted in reduced induction of HMOX1 by HPP - 4382, CoPP and bardoxolone, consistent with the well - characterized role of Nrf2 as a critical activating transcription factor for HMOX1.

Components of the major metazoan developmental signalling pathways, as well as classes of developmental transcription factors, are mostly present in Amphimedon and absent from Monosiga and other non-metazoan genomes13, 14,16,27,29, suggesting that ontogenetic development, including primary germ cell formation (Supplementary Note 8.4), originated on the metazoan stem3, 11,12.

The 1500 transcription factors (TFs) within the human genome perform a key role in determining the set of active genes within a specific cell, as well as the magnitude of activity.

Previous whole - genome chromatin immunoprecipitation analyses have identified a wide set of Oct4 target genes [6], [28], as well as describing co-occupancy of Oct4 and other transcription factors at many of these genes [6].

These four proteins are well known EMT transcription factors that function as decisive early drivers of EMT.

In addition, LA promoted inflammatory processes activating the nuclear factor - κB transcription factor as well as stimulating the expression of cyclooxygenase - 2 and pro-inflammatory cytokines.

For example, enterolactone made from flaxseed lignans has been shown to be an estrogen agonist (promoting estrogen production, through increased formation of transcription factors like ER - alpha and ER - beta), as well as an estrogen antagonist (working against estrogen production, through inhibition of enzymes like estrogen synthetase).

Three Presentations, a double - sided worksheet on epigenetics and a fun class quiz which cover the following topics: Transcription Factors and the Oestrogen Receptor, DNA methylation and Histone Acetylation (epigenetics), RNA interference, as well as how these are implicated in cancers.