Sentences with phrase «well in clinical trials»

When the cat was let out of the bag, in the form of disclosure that the drug didn't perform well in clinical trials, the company's stock plummeted 67 percent.

The drug has performed well in clinical trials and is registered in a number of developed and developing countries, he said.

Not exact matches

«Watson is able to give us faster, better matching of patients to potential clinical trials that our oncologists wouldn't have otherwise be able to see — and I sit with our oncologists who work on this kind of thing,» Christopher Ross, CIO at the Mayo Clinic, told MobiHealthNews in an interview.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

In a clinical trial of more than 600 participants, Empliciti, when used with cancer drug Revlimid and steroid dexamethasone was better at delaying when the cancer worsened than just the two drugs alone.

Through talking to experts in the field over the past year, Gates said he had identified five areas of need: Understanding better how Alzheimer's unfolds, detecting and diagnosing it earlier, pursuing multiple approaches to trying to halt the disease, making it easier for people to take part in clinical trials of potential new medicines, and using data better.

HERERA: Merck (NYSE: MRK) was one of the best performing stocks on the blue chip Dow index today, after the drug company «s new type of lung cancer drug performed better than expected in a highly anticipated clinical trial.

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

Preveceutical said in a release that Australia's specialized hospitals with strong clinical trial capabilities as well as the country's diverse...

This oral product was potent, well tolerated, and showed no serious side effects in clinical trials.

Since 2008, Good Cookies like YOU have helped fund dozens of pediatric cancer research grants, resulting in NINE promising new treatments moving to clinical trial, now available to children with cancer.

In a clinical trial led by the University of California, Davis Medical Center, babies that were given Evivo showed an 80 % reduction in potentially harmful bacteria such as E.coli, Clostridia, Staph, and Strep and a 79 % increase in good gut bacteriIn a clinical trial led by the University of California, Davis Medical Center, babies that were given Evivo showed an 80 % reduction in potentially harmful bacteria such as E.coli, Clostridia, Staph, and Strep and a 79 % increase in good gut bacteriin potentially harmful bacteria such as E.coli, Clostridia, Staph, and Strep and a 79 % increase in good gut bacteriin good gut bacteria.

Our Cord Blood Education workshop here in Halifax with Insception Lifebank has shared a wealth of knowledge with expectant parents regarding clinical trials and treatments as well as emerging research.

In addition to clinicians focusing on patient care, we have clinicians who also are educators and scholars as well as translational or clinical trial scientists.

Our Cord Blood Education workshop here in Halifax with Insception Lifebank has shared a wealth of knowledge with expectant parents regarding clinical trials and treatments as well -LSB-...]

It will house 150 researchers and clinician scientists, as well as an additional 100 people working in clinical trial design and administration.

Unlike many clinical trials that emphasize relief of symptoms as their primary objective, the ezogabine study's goal is to gauge how well the therapy addresses some of the biological underpinnings of depression — in this case, whether the drug lessens the hyperactivity of the reward circuit that includes VTA neurons.

Running a large clinical trial requires good skills in communication as you will have to work with many people and many organisations.

«In the future, we hope that this information can be utilized in dividing the patients into different genetic susceptibility groups for clinical drug trials, thus increasing the chances of identifying the best possible treatment for each subgroup,» he continueIn the future, we hope that this information can be utilized in dividing the patients into different genetic susceptibility groups for clinical drug trials, thus increasing the chances of identifying the best possible treatment for each subgroup,» he continuein dividing the patients into different genetic susceptibility groups for clinical drug trials, thus increasing the chances of identifying the best possible treatment for each subgroup,» he continues.

NIDA will first conduct more animal trials, and then, if all goes well, move on to clinical trials in addicts.

The authors say that the well - established safety profile of metformin for diabetes should hopefully encourage clinicians to translate these findings into clinical trials to improve sustained abstinence rates in ex-smokers.

Lanza says that this time, he aims to do things right: direct good science focused on treating disease, publish in reputable journals with rigorous peer - review processes and work with high - quality collaborators and clinical centres for its trials.

Better memory boosters now in clinical trials should be here in four to five years.

A damning report on how the University of Minnesota (UM) protects volunteers in its clinical trials concludes that researchers inadequately reviewed research studies across the university and need more training to better protect the most vulnerable subjects.

What little encouraging Alzheimer's treatment data does exist — including that around a promising drug called aducanumab — suggests medications that have gone through clinical trials seem to work better earlier in the dementia disease course, before patients develop full - blown Alzheimer's.

They actually rank methodologies — clinical trials supposedly being in some sense a better methodology than observational studies, for instance.

«The good news is that drug companies are using our skin biopsy technique in ongoing clinical trials to monitor treatment success.»

Clearly, there is an urgent need for better methods to predict the safety of medicines for patients as well as volunteers in clinical trials.

With A3AR drugs demonstrating good safety profiles in clinical trials as anti-inflammatory and anti-cancer agents, Salvemini and colleagues are enthusiastic about the potential of these new drugs to treat chronic pain in patients.

Success with these models led to a small phase I clinical trial in which an individual's good bacteria with antimicrobial activity was grown, formulated in a skin cream and applied once to the forearm of the eczema patient infected by S. aureus.

«If we find that lymphoscintigrams using tilmanocept are at least as good as the conventional radiocolloid tracer in identification and visualization of sentinel nodes, we would like to see a randomised clinical trial involving large numbers of patients,» says Prof de Bree.

She says a number of experimental drugs now in clinical trials are designed to target serotonin in other ways in the brain, and may have better success than the SSRIs.

The researchers suggest a clinical trial should be carried out to compare which of the two strategies is better in treating infection, but it will require several thousands of patients with hip infections.

Having performed well in hospital - based clinical trials in 2010, the digital pancreas is now being tested in a real - world environment.

Several other small companies, including Bentley Pharmaceuticals in Exeter, N.H., are conducting clinical trials on insulin nasal sprays as well.

Others have speculated that, by being involved in a clinical trial, patients in both arms of the trial received better care than they would otherwise have done, obfuscating any differences between the groups.

The group's models could also help interpret data from future clinical trials that evaluate the effectiveness of booster shots in schoolchildren, «as well as predict the potential impact of new vaccination strategies,» he said.

In a randomized, controlled clinical trial — the first of its kind — a multi-institution research team reports that daptomycin, part of a new class of antibiotics currently approved only for use in adults, is effective and well - tolerated in childreIn a randomized, controlled clinical trial — the first of its kind — a multi-institution research team reports that daptomycin, part of a new class of antibiotics currently approved only for use in adults, is effective and well - tolerated in childrein adults, is effective and well - tolerated in childrein children.

A phase III clinical trial in hundreds of people must be performed before the treatment could be recommended for smokers, and Dr. Yuan warned that while eating cruciferous vegetables, such as watercress and broccoli, is good for people, they are unlikely to have the same pronounced effect as the extract.

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»

Toxicologist Thomas Hartung of the Johns Hopkins Bloomberg School of Public Health in Baltimore agrees: «Clinical drug trials in general are very well designed.

It estimates the societal burden of 1,400 medical conditions in the U.S. over a 12 - year timespan, based on frequency of diagnosis and health care insurance costs, as well as research publications, awarded grants and clinical trials for each condition.

NCIC CTG is excited to partner in the development of this clinical trial, which will be funded by a grant from the TFRI as well as grants from Canadian Cancer Society Research Institute to NCIC CTG,» says Seymour.

The determination of each efficacy level was also based on the rigor and quantity of published studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.

Many patients and physicians assume that the safety and effectiveness of newly approved drugs is well understood by the federal Food and Drug Administration (FDA)-- but a new study by researchers at Yale School of Medicine shows that the clinical trials used by the FDA to approve new drugs between 2005 and 2012 vary widely in their thoroughness.

He's also likely to spur the FDA to follow the course laid out by agency cancer czar Richard Pazdur in speeding new approvals, possibly setting up a special unit aimed at orphan drugs to hasten OKs with smaller, better designed clinical trials.

Meanwhile, his research teams are moving several other novel therapies toward clinical trials, each of which has potential for use in the synergistic model of cancer treatment that Black believes will offer the best hope for his patients.

His work in designing anticancer compounds had led to millions of dollars in funding and multiple patents, as well as two compounds in clinical trials.

As he works to better understand the biology of neratinib - induced Ras inhibition, Dent hopes his laboratory findings can be validated in clinical trials testing a combination of neratinib and valproic acid in patients with afatinib - resistant NSCLC.

Biological treatment of psoriasis shows a good efficacy in clinical trials.