Sentences with phrase «well in human patients»

Not exact matches

In a later study of the well - being of coronary patients, Holden (1981) reported that ownership of a pet among ninety - three patients was the strongest predictor of survival, stronger even than human relationships.

But there is an illumination and we can know that there is a patient, redemptive reality in and through all of life which transmutes real evil, real loss, real threats to the growth of human good into the deeper, more sensitive and more enduring goods of love and humility?

A lot of things we've been told are best turn out to have other consequences, and those are conversations we NEED to have... if we truly have what's best for the patient (human or canine) in mind.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

A dozen human studies of MDMA, LSD, a powerful African drug called ibogaine and psilocybin, from so - called «magic mushrooms,» are now under way, testing the once - stigmatized drugs as treatments for not only PTSD, but also cluster headaches and addiction, as well as anxiety and depression in cancer patients.

Researchers compared how well IDx - DR detected diabetic retinopathy in more than 800 U.S. patients with diagnoses made by three human specialists.

«The human genes and pathways that Tat manipulates correlate well with symptoms observed in these patients, such as immune system hyperactivation, then weakening, and accelerated aging,» Dr. D'Orso said, describing the situation in which HIV infection leads to AIDS.

When a physican needs help diagnosing or treating a patient they open the Human Dx smartphone app or visit the project's Web page and type in their clinical question as well as their working diagnosis.

«The rules, whether to protect human patients and research animals or prevent financial conflicts of interest, are often well - intentioned, academic officials say,» wrote Malakoff Monday in another After Election 2014 post.

By assessing the survival of the cells that engulf the particles and measuring the levels of red or green light that they emitted, the researchers determined which formulation of particles performed best, then tested that formulation in mice with human brain cancer derived from their patients.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

Given that in humans HTR7 is also expressed in the neurons that innervate the skin, this new gene may well be responsible for itch in human patients taking antidepressants.

Marc Wolfson, public affairs specialist on emergency preparedness for the Department of Health and Human Services, isn't so confident: «We can develop the best countermeasures in the world, but if they're not there in time to help treat the patient, then they're not effective.»

They also found elevated granzyme A levels in blood samples taken from non-human primates infected with chikungunya, as well as from human chikungunya patients.

The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.

«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance, of stem cells in hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department of Dermatology.

On the other hand patients with DRB1 * 04:01 have a better clinical outcome in the short - and long - term suggesting that human leukocyte antigen (HLA) analysis and screening for SLA / LP antibodies should be integrated in the clinical routine for AIH diagnosis.

Previous studies have shown the drug to be effective at spurring new bone growth in mice and in humans with osteoporosis, and a U-M research team believes that it may spur new growth in brittle bone disease patients as well.

Despite encouraging evidence from animal studies that it clears amyloid from the brain, when it came to clinical improvements in human patients the drug proved no better than placebo in two phase III clinical trials.

If it works in humans, the technique could prolong the lives of some brain cancer patients, and it might be applicable to other types of cancer as well.

The researchers also hope that the algorithm will enable other researchers to study the pathway, possibly leading to a better understanding of its role in human cognition and in patient populations.

«If dexamethasone works well in humans, we could potentially use it to prevent fearful memories in soldiers on the battlefield, patients in emergency rooms, or anywhere else where healthcare providers provide treatment within hours of traumatic events.»

In the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better visioIn the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better visioin one eye have experienced no harmful side effects and appear to have slightly better vision.

The mice show many of the symptoms that human patients do, and so they were an especially good candidate to test iPS cells» abilities, says stem cell researcher Rudolf Jaenisch of the Whitehead Institute for Biomedical Research and the Massachusetts Institute of Technology, both in Cambridge, who collaborated with Townes on the project.

Guselkumab, a fully human monoclonal antibody targeting IL - 23, in this Phase 2 study for the treatment of PsA, was well tolerated with no unexpected safety findings in this patient population.2 Guselkumab is now being pursued in a Phase 3 development programme for psoriatic arthritis.

These instruments have formed the foundation for the biochemistry cores of two NIH Centers of Excellence (the NIAAA - funded TSRI Alcohol Research Center and the National Institute on Drug Abuse [NIDA]- funded Scripps Center for Cannabis Addiction Neurobiology) and have directly supported other ongoing projects at TSRI (the Methamphetamine NeuroAIDS Research Program, NIDA - funded projects on immunopharmacotherapy [Taffe and Janda laboratories], a project with Dr. Steve Poceta to measure human lumbar cerebrospinal fluid in Parkinson's patients with Restless Leg Syndrome, and a U.S. Army grant), as well as assisting non-TSRI collaborators from The Sanford - Burnham Institute, The Salk Institute, and elsewhere.

And, while the genetically - modified mice were made somewhat better by deactivating the HD gene in their hypothalamus, this approach isn't useable in human HD patients because their HD genes don't contain the sequences needed to turn them off with virus used by Petersen and colleagues.

While translational research has traditionally moved basic immunology knowledge forward into clinical application, varying clinical presentations of human immune - related disease processes, as well as variability in therapeutic outcomes, have provided opportunities for discovery of novel mechanistic hypotheses directly from patients.

The aim of this clinical trial is to replicate in humans the same results observed in mice and, ultimately, lead to an effective, nontoxic treatment for newly diagnosed patients as well as patients who can no longer benefit from conventional treatments.

Today a professor of Pediatrics, Neurology, Neuroscience, and Molecular and Human Genetics at Baylor College of Medicine, and an investigator at the Howard Hughes Medical Institute, Dr. Zoghbi says her ultimate professional goal is «to actually make a patient better» through treatments resulting from her discoveries in research.

The good safety profile of Aducanumab in patients may well be attributed to the antibody's specific capacity to bond with the abnormally folded beta - amyloid protein fragment as well as the fact that the antibody is of human origin.

«Ultimately, we have to get a human model for human diseases so that we can expand human experimental biology in an ethical way and ensure that better, safer drugs get to patients faster,» he says.

There are lots of different HD mice available, and because every case of HD is caused by the same basic genetic mutation, it may be that «our» mice will turn out to be better than those of other diseases, at predicting success in human patients.

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

He has also been awarded the American Society of Human Genetics Curt Stern Award for Outstanding Scientific Achievement, the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) Peter and Edith O'Donnell Award in Medicine, the SPR E. Meade Johnson Award for Pediatrics Research, the Michael E. DeBakey Excellence in Research Award, the American Philosophical Society's (APS) Judson Darland Prize for Patient - Oriented Clinical Investigation, and Best Doctors in America.

Although this approach has yet to be tested in humans, this study suggests that combining two existing cancer immunotherapies can significantly boost their efficacy, resulting in better outcomes for patients.

Infected patients are at - risk for long - term joint stiffness and pain, which increases the need to better understand the sequence diversity of these viruses and how any viral mutations affect the severity of disease in the human host.

This project provides the opportunity to record intracranial LFP signals from the olfactory as well as the limbic regions of the human brain while patients participate in various olfaction - based behavioral paradigms.

The authors were able to correct mutations in several well - characterized genetic disorders, including: Duchenne Muscular Dystrophy, Achondroplasia, and MECP2 - duplication syndrome using cells derived from human patients.

I think we all agree that we over treat prostate cancer in this country compared to what you see in Europe with similar outcomes and so but I think this is where the human or the Cancer Genome Project or at least better biomarkers for looking at mutations that we already know occur in these diseases I think hopefully within the next few years every single patient who is diagnosed with prostate cancer those biopsies will be characterized and then the patients followed, hopefully watchful waiting and we'll ultimately get a correlation between what mutational events predict a rather dormant disease as opposed to a very aggressive disease.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

We participate in Therapaws of Michigan, which sends calm, well - behaved therapy dogs and their human companions to visit patients and families in the hospital.

Supported by the resource of more than 42 000 unique human protein fragments generated within the Human Protein Atlas, representing more than 18 000 human protein coding genes, we offer proteome wide screening for autoantibody reactivity, on the, as well as downstream solutions for investigation of autoimmunity in hundreds of patient samples in parahuman protein fragments generated within the Human Protein Atlas, representing more than 18 000 human protein coding genes, we offer proteome wide screening for autoantibody reactivity, on the, as well as downstream solutions for investigation of autoimmunity in hundreds of patient samples in paraHuman Protein Atlas, representing more than 18 000 human protein coding genes, we offer proteome wide screening for autoantibody reactivity, on the, as well as downstream solutions for investigation of autoimmunity in hundreds of patient samples in parahuman protein coding genes, we offer proteome wide screening for autoantibody reactivity, on the, as well as downstream solutions for investigation of autoimmunity in hundreds of patient samples in parallel.

As we produce more human - relevant data with our Organ - Chips, we look forward to making a positive impact on informing R&D decisions, reducing drug candidate attrition in human clinical trials, and helping to deliver better and safer medicines to patients.»

Insofar as we can generalize from these animal experiments to humans, they provide a potential rationale for using low - protein diets to treat cancer patients, and raise the important clinical question of how to best maintain proper detoxification in these patients.

The researchers noted that the mouse results may have implications for human health as well, as they also found an E. coli variant with the suspect genes in high percentages of human patients with colorectal cancer and irritable bowel disease.

Good for diabetic patients: It also includes a mixture of grains like jowar, bajra, maize (along with the outer kernel) mixed pulses which help in contributing to the health of the human body.

The use of HGH or Human Growth Hormone is growing in popularity among anti aging medical professionals or age management physicians, to aid their patients in enhancing their overall well - being and to help those who are suffering from a hormonal imbalance, or Andropause (the male menopause).

Another human study (Tayebi Khosroshahi HI 2018) found that resistant starch significantly reduced inflammatory and oxidative biomarkers TNF - alpha, IL - 6, malondialdehyde as well as serum urea and creatinine in hemodialysis patients.

Given the initial skepticism, I learned to trust my gut, be patient, and have faith in elegantly simple solutions to human problems that people might suppose would be better solved by sophisticated technology.