Sentences with phrase «what cells it targets»
Not exact matches
What Stephen Hawking Missed: Small Biotechs Developing Promising Cell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investCell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investcell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investors.
http://www.thelifesciencesreport.com/
Different CARs determine what types of tumors T cells target.
Therefore, if one would want to enhance this clearance in patients, one would need to know what cells to target.»
Working backwards from the target on a virus, malignant cell or other disease - causing agent, researchers determine what the basic conformation of the peptide should be.
«What we decided to do was take a completely unbiased approach where instead of targeting individual genes of interest, we would express randomized guides inside of the cell,» Lu says.
«They're what viruses, bacteria and other cells see first when they touch down on a target cell.»
For investigators who know what their target cells look like, it might be best to pick them out manually.
«Only by understanding the complexities of what happens in specific cell - types found in specific areas of the brain during this disease can targeted treatments for Parkinson's disease be produced.»
Wapner's narrative follows developments from the recognition of a chromosomal abnormality in cancer cells to the production of a targeted drug against what had been a lethal leukemia.
Co-senior study investigator and cancer biologist Iannis Aifantis, PhD, says the study offers the first evidence that «drugs targeting and disrupting leukemia cells» microenvironment — or what goes on around them — could prove effective against the disease.»
What's more, they identified Cas as a critical, tissue - specific target of Hh signaling, which not only plays a key role in maintaining follicle stem cells but also assists in the diversification of their progeny.
The researchers will now work to better understand what goes wrong in GRN - mutated cells, as well as identify precise molecular targets that could then be used for drug screens.
The researchers found that Zika targeted two specific cell types in mice: spermatogonia, which make sperm, and Sertoli cells, which are involved in helping sperm develop and sheltering them from the blood and immune system, building what's called the blood - testis barrier.
What if drugs for cancer, cardiovascular disease, and other diseases can be targeted specifically and only to cells that need the medicine, and leave normal tissues untouched?
What it does is give us a target for development of more efficient and cancer stem cell specific therapies to eliminate the cancer.
«Scientists find what might be responsible for slow heart function under general anesthesia: New research in The FASEB Journal suggests that general anesthesia targets certain amino acids on proteins of the heart muscle fibers and cells which directly affects the ability of the heart to pump.»
What's more, the new BZY cells work best at about 500 °C, the sweet spot temperature targeted by the fuel cell industry.
Piwi - interacting RNAs are a type of small RNAs that associate with what's known as Argonaute machinery in cells that search for target RNA and shut it down.
«Disjointed: Cell differences may explain why rheumatoid arthritis varies by location: Findings point to new approaches in targeted therapies so that what works for arthritic hands may not be the same for ailing hips.»
Kasid said: «If the cells are targeted to the tumour, what additional effects would release of cytokines locally have on the tumour?»
This is our dream for personalized cancer therapy, so we're not just guessing any more about which drugs will work but can choose drug targets based on what's driving that patient's cancer,» said Josh Stuart, the Baskin professor of biomolecular engineering at UC Santa Cruz, director of cancer and stem cell genomics at the UCSC Genomics Institute, and a senior corresponding author of the paper.
What's more, with different locks, the nanorobots could be designed to target any type of cell.
The advent of molecular cloning, DNA sequencing and the many tools of molecular genetics and cell biology has given us sufficient knowledge of the basis for disease and the genes to target, but what has limited the application of gene therapy has been efficient gene delivery systems.
«I'm trying to learn all the downstream targets and find what inhibitors we can combine... to accelerate cell death.»
So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.
According to Dr. Burgess, the team is now working to extend the period that sperm cells can be cultured, so there is more time to select cells that have the foreign gene inserted in specific areas of the genome in what is commonly called a «targeted gene knockout.»
In the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.»
With their deep expertise in the biology of senescent cells, the Campisi lab will be focused on fundamental research into questions like how senescent cells vary in their susceptibility and resistance to immune clearance (depending on factors like their tissues of residence or the pathway that led them into senescence); the targets and mechanisms used by NK cells to clear senescent cells; and why subsets of senescent cells might persist when their similarly - situated neighbors are cleared out (and what might allow us to overcome that resistance).
The CRISPR - Cas9 genome editing system could help fight cancer, and now, researchers have used the tool to target what they call cancer's command center, in a treatment that's been shown in mice to shrink aggressive tumors and increase survival rates, without harming healthy cells.
If cell death is a slow process, maybe there are some hallmarks, some harbingers, of what happens before cell death that would give you a good clinical target for slowing or preventing the disease.
However, scientists disagree on whether the phenomenon of cancer stem cells extends to different kinds of cancer and what is the best way to target them.
Understanding the role of glial cells in glaucoma as well as what happens to the optic nerve where the retinal nerve axons leave the eye may present new therapeutic targets and even potential biomarkers of glaucoma.
What I hope to bring to Catalyst for a Cure is an understanding of both healthy ganglion cell biology and some insights into potential targets for rescuing and replenishing ganglion cells when they're injured in glaucoma.
What's more, one transcription factor typically targets thousands of genomic locations in the cell and changes gene expression at each location.
«What is important is to be able not only t0 target leukemia cells selectively, but also to eradicate cancer stem cells as well,» Fasan says.
In laboratory studies with normal and cancer cells, the new radiation delivery system proved able to specifically target colon cancer cells, and what's left over is likely to be easily filtered out by the kidneys because the delivery system's molecules are so small.
«In the past, the search for drug targets has been guided mechanistically - by asking what karyotypic abnormalities are found in a cancer cell or what's responsible for a hereditary cancer predisposition,» said Vogelstein.
«With this technology, you can test the function of these candidate genes and measure what percentage of cells are generating into our target arterial cells,» says Zhang.
What's more, both the cell culture and the mouse models will facilitate the identification of novel targets for PD therapy.
Targeting cancer stem cells and protecting DNA doesn't even scratch the surface of what broccoli and broccoli sprouts appear capable of.
It is kind of difficult to go to a regular club and flirt, because most of your targets simply do not know the sign language, they are not patient enough to be typing all the messages on the cell phone, and you can not really make out what they are saying by reading their lips because they are just way too hammered.
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(While Twitter and other companies accept the need to conceal the target of the orders, such as the members of a suspected terror cell, they insist the First Amendment lets them tell the public about what laws the government is using in the first place.)
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