A signaling pathway is how developing cells get instruction on
what types of cell to become, such as a liver cell, a skin cell, a brain cell, etc..
If edible beef is the goal, you don't want any hoof or fur mixed in with it, but as of now, scientists can not consistently control
what type of cells are produced.
By repeating the experiment over and over, however, they are assembling a picture of
what types of cells exist, how those cells function during tasks of place memory, and what kinds of connections they form with other cells.
«It really hasn't been explored when these activity networks — these collections of brain areas that start to work together in the brain — emerge and
what types of cells and tissues they emerge in,» says Colin Studholme, Ph.D., a professor with joint appointments in pediatrics and bioengineering at the University of Washington and senior author of the paper.
By manipulating the signals that the cells see at a particular time, the researchers were able to influence
what type of cell they become and how they are organised.
How stem cells decide
what type of cell to become is another mystery, but scientists are finding clues to the answer.
For instance, stem cells seem to pick up chemical signals from surrounding bone cells about when to divide and
what types of cells to create.
Learning
what type of cell starts a particular cancer — the «cell of origin» — is extremely valuable, providing insights into tailored therapies that are most likely to work.
You can't always tell exactly
what type of cells they are.
This may include testing for parasites, evaluating
what type of cells, infectious organisms, bacteria, or fungal infections are present, or collecting a skin biopsy in the case of a mass.»
Not exact matches
Different CARs determine
what types of tumors T
cells target.
«
What this research shows is that they're using the same
cell types with the same kinds
of connections we see in the neocortex, but with a very different kind
of organization.»
We wanted to understand
what types of differences are always there,
what is causing them, and
what they mean,» says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and co-senior author, with Kelly Frazer
of the University
of California, San Diego, on the new paper, which was published in
Cell Stem
Cell in April 2017.
«If we fed the fish a specific
type of fat, our technique allowed us to determine into
what molecules these lipids were reassembled after they were broken down in the small intestine and in which organs and
cells these molecules ended up,» Farber explained.
Since the cancer
cells in both
types of tumors were the same, the researchers compared the noncancerous
cells present in the induced and transplanted tumors to explore
what might be causing the T
cell apoptosis.
«By observing entorhinal - hippocampal neurons based on their birthdate, we realized that these
cells were somehow special and very different from the other surrounding
cell types, which was instrumental to find out how and to
what extent they influenced the assembly
of the network.»
«Only by understanding the complexities
of what happens in specific
cell -
types found in specific areas
of the brain during this disease can targeted treatments for Parkinson's disease be produced.»
Researchers say their findings, published in Annals
of Neurology, are «surprising» as the results differ from
what has been seen in studies
of brain regions that harbor other brain
cell -
types.
But like the medieval alchemists, today's cloning and stem
cell biologists are working largely with processes they don't fully understand:
What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a
cell's differentiation as smoothly as nature's program
of development does every time fertilized egg gives rise to the multiple
cell types that make up a live baby.
Looking further into the intestinal crypts
of both the transgenic and wild -
type mice, the research team made
what they consider a surprising finding: Not only was HMGA1 causing the stem
cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number
of Paneth
cells, a
type of niche
cell known to support intestinal stem
cells.
What he instead plans to do is turn the iPSCs into blood - forming stem
cells, which when transplanted into the body would give rise to all
of the
cell types found in the blood.
Stem
cells, the blank slate from which the body can build any
type of cell it needs, are proving themselves capable
of doing
what was once thought impossible: healing broken brains.
«The
type of inflammation we see in psoriasis is similar to
what we see in atherosclerosis — a
type of heart disease that involves the build - up
of fats, cholesterol, and inflammatory
cells in the artery walls,» Gelfand said.
The human brain consists
of thousands
of different
types of nerve
cells that are all formed out
of what in simple terms can be described as immature stem
cells.
«The takeaway is you should decide
what type of solar
cell you're using based on the
type of climate in your area,» says Peters.
This allows users to determine either where their solar
cell would work best or
what type of solar
cell they should use in their location.
Bioengineers should also take note, he says: They may need to consider
what forces to apply to cultured stem
cells to coax them into the desired
type of cell.
She hopes to pinpoint which genes are expressed in each
cell type when brain
cells make long distance connections, and to make similar maps in other primates to chart
what changed as brains rewired over the course
of evolution.
As part
of ENCODE, 32 institutions did computer analyses, biochemical tests, and sequencing studies on 147
cell types — six fairly extensively — to find out
what each
of the genome's 3 billion bases does.
What appear as stripes across the solar
cell module are lines
of either cathode -
type or anode -
type material.
The specific pattern
of epigenetic marks in a
cell type specifies identity and this epigenetic control is vital to
what makes our
cells different, for example a skin
cell from a liver
cell, when they all contain the same genetic instructions.
Part
of what makes each
cell type unique is its distinctive pattern
of DNA structure and regulatory factors.
Now a team at the Wyss Institute
of Biologically Inspired Engineering at Harvard University and Harvard Medical School, in collaboration with the Allen Institute for Brain Science, has developed a new method that allows scientists to pinpoint thousands
of mRNAs and other
types of RNAs at once in intact
cells — all while determining the sequence
of letters, or bases, that identify them and reveal
what they do.
«We're interested in learning more about
what other proteins LRP6 interacts with, as well as how it acts in different
types of brain
cells at different developmental stages
of circuit development and refinement.»
«We don't know
what it actually does in the
cell —
what activates it,
what it interacts with, and the specific
type of DNA damage it repairs,» she says.
What's more, the resolution — the highest so far in these
types of studies — was good enough to discriminate structures as small as individual
cells.
We believe that each dog breed may correspond to one
type of B - or T -
cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects
what type of tumor develops, and how its progression is regulated,» says Ingegerd Elvers.
What about the nucleated (eukaryotic)
cell —
cells of the
type that make up higher plants and animals?
To determine
what types of animals hCoV - EMC can infect, Drosten and colleagues infected
cells from humans, pigs, and a wide variety
of bats, the key natural reservoirs
of coronaviruses.
They are responsible for adding sugar molecules to numerous different
types of proteins, whether it's a
cell wall, or it's a small signaling peptide, which is
what's responsible for the phenotypes in tomato.»
«We want to know
what the basic function
of GATA - 3 in regulating
cell biology is, although it has been shown that GATA - 3 is important for the function
of CD4 + T
cell type to clear extracellular parasites,» said Yisong Wan, PhD, assistant professor
of microbiology and immunology at the UNC School
of Medicine and member
of UNC Lineberger Comprehensive Cancer Center.
Using tissue culture models
of cartilage and the meniscus, Levenston's team stresses the
cells and tissues and studies
what happens to them structurally and biochemically — for example, whether different genes are expressed, whether metabolism changes, or whether different
types of cartilage
cells respond differently to the same stress.
But
what chemical is involved depends on the
type of cell within the bud.
Piwi - interacting RNAs are a
type of small RNAs that associate with
what's known as Argonaute machinery in
cells that search for target RNA and shut it down.
The team immersed the stem
cells in four different
types of these cultures and analysed which genes they expressed in which environment, and to
what extent.
The
cell bodies make up
what is known as grey matter, brain areas where particular
types of processing happen.
One way
of thinking about
what differentiates a breast
cell from a heart
cell is that each
cell type expresses different subsets
of genes.
«We're approaching half
of what, for example, I could probably
type on a
cell phone,» says neurosurgeon and co-senior author, Jaimie Henderson
of Stanford University.
It also suggests that the
type of impairments clones experience may depend on
what kind
of body
cells are used as donor
cells.