Sentences with phrase «when cell block»

Not exact matches

Combating inflammation According to the JNCI, Capsaicin blocks the activation of nuclear transcription factors in the cells» nuclei that, when activated by exogenous or endogenous free radicals or toxins, cause inflammation throughout the stomach and body.

Inflammatory breast cancer is a rare and aggressive form of breast cancer that occurs when malignant cells block the skin and lymph vessels of the...

Felix Figueroa, 39, of the 2800 block of North Natoma Avenue, had been arrested for a traffic offense and placed into a cell when a surveillance camera inside the lockup filmed Figueroa as he bit one end of the mattress cover, then tore it open and removed the foam inside, police said.

They found that antibiotics disrupted the mice's gut microbiomes, decreasing the activity of neutrophils and blocking these important white blood cells from responding when needed.

A study published on December 3rd in PLOS Pathogens suggests that one such strategy blocking the PD - 1 / PD - L1 pathway works, but only when the overall HIV load is low and regulatory T cells cooperate.

Based on these ex vivo experiments (in cells isolated from patients and then exposed to PD - L1 blocking agents outside of the body), they predict that when actual patients are given PD - L1 blocking agents, their viral load at the time will influence the «net» outcome, i.e., whether the blockage boosts or weakens the overall anti-HIV immune response.

When Tang depleted a particular myristic acid derivative from the germ cells in hermaphrodite worms by blocking the action of ACS - 4, the worms never made the switch to making eggs.

The analysis of the ploidy of minichromosomes in cells that are released from arrest demonstrates that the sister molecules are properly segregated when the cell cycle block is removed.

«When we block the path into the cell, we also block the functional effects of the exosomes.

VOC occurs when the misshapen, sickled red blood cells block blood flow in the blood vessels.

When an existing drug was given that blocks the DNP in a leukemia cell, the dCTP nucleotide was still produced by the NSP and the leukemia cell survived.

When both these drugs are given, both pathways are blocked with a one - two punch, the leukemia cells can not produce dCTP nucleotides, and the cells die.

In other experiments, the protein blocked the virus from infecting cells in culture, and it even prevented mice from getting sick when administered either 1 day before or after viral exposure, they report today in Nature Biotechnology.

When compounds that block the «message» channels in cell membranes were added to the dish, there was no damage to fibroblasts.

When someone has a heart attack due to a blocked artery, the heart is deprived of oxygen (an effect called ischemia) and cells die.

Next, Lu et al. found that 3BNC117 was not effective at clearing infected cells when their Fcγ receptor was mutated or blocked, suggesting that this receptor is a key mechanism behind 3BNC117 - mediated clearance of HIV - infected cells.

«We have shown that when FBW7 is functionally inactivated this leads to a block of degradation of the stem cell protein SOX9 which becomes more stable in the brain cancer cells,» said first author Aldwin Suryo Rahmanto at the department of Cell and Molecular Biolcell protein SOX9 which becomes more stable in the brain cancer cells,» said first author Aldwin Suryo Rahmanto at the department of Cell and Molecular BiolCell and Molecular Biology.

«It makes perfect sense for the cell to have such a mechanism and not even try to produce RNA when its building blocks are lacking.»

The T cell migration halted again when the team added a chemical that blocks the IGF - 1 receptor, the authors report 23 August in the Journal of Immunology.

«We demonstrated that alpha - KGDH interacts with Gcn5 in the cell nucleus and found that tumor cell proliferation and tumor growth were inhibited when alpha - KGDH was blocked from entering the cell nucleus or by disruption of Gcn5's binding to succinyl - coenzyme A,» said Lu.

Experiments showed that HIFs controlled the production of GSTO1 in breast cancer cells when they were exposed to chemotherapy; if HIF activity was blocked in these lab - grown cells, GSTO1 was not produced.

A new study shows that these cells alter their behavior and structure when the animals» hearing is blocked.

When bortezomib blocks the ability of the cell to clear these protein clumps, they grow larger and become toxic to the cancer cells.

«Although, both ketamine and memantine have similar actions when nerve cells are active, under resting conditions, memantine is less effective in blocking nerve cell communication compared to ketamine, This fundamental difference in their action could explain why memantine has not been effective as a rapid antidepressant» said Dr. Monteggia, who holds the Ginny and John Eulich Professorship in Autism Spectrum Disorders.

The study, published in the Journal of Neuroscience, found that when microglia, the brain's resident immune cells, were blocked, female response to opioid pain medication improved and matched the levels of pain relief normally seen in males.

When DIXDC1 is blocked or inactivated, focal adhesions become small and numerous, resulting in hundreds of small «hands» that pull the cell forward in response to extracellular cues.

The antibody blocks CTLA - 4, a protein switch on the surface of T cells that, when turned on, dampens their activation.

On the other hand, when the researchers blocked f - circRNA activity, the cells» normal behaviors were restored.

The researchers found that cells synthesized fewer deoxyribonucleotide triphosphates (dNTPs)-- the building blocks of DNA — when PGAM1 was inhibited.

BCL - 2 is present in high amounts in many tumors and helps cancer cells to survive, but when the BCL - 2 gene is blocked by MM41 in mice, the cancer cells succumb to apoptosis and die.»

When the scientists blocked Treg cells from accumulating in the fat by targeting a molecule that the immune cells require, mice no longer developed type 4 diabetes in old age.

When the team blocked the activity of L1CAM in cultured human colon cancer cells, the cells» growth slowed dramatically.

When they inserted a fluorescent reporter protein in this virus - like shell, their test became capable of high - speed screening to see which drugs blocked the entry of Ebola - like viral particles into cells as measured by fluorescence.

Donn says: «When the enzyme is blocked, ammonia accumulates in the chloroplasts, eventually leading to the destruction of the chloroplasts and plant cells, so that the plants die.»

Although not an antioxidant, the mineral partially blocks cells» docking sites for glutamate, the chemical signal that overexcites nerve cells when noise becomes excessive.

When they blocked TOR signals, cells took longer to recover from ER stress and the ER factory shrank.

Their idea emerged from test - tube experiments that Munn did years ago, when he showed that some macrophages could stop T cells in their tracks by starving them of a building block called tryptophan.

Furthermore, when they blocked the action of the gene using RNA interference, the cell proliferation index was reduced.

«Interestingly, even when we blocked the signalling mechanism in mice not subjected to a stroke, the astrocytes formed new nerve cells,» says Zaal Kokaia.

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy - induced neuropathy and HIV.

However, when neonatal mice were weaned onto an antigen - free elemental diet or a diet free of proteins, but only their amino acid building blocks, they didn't develop pTreg cells in the small intestine.

The researchers performed lab experiments on cells derived from a cervical cancer and found that when DOHH is blocked, a protein known as eIF5A fails to mature.

The team, led by Ara Hovanessian, says that when the receptor is blocked, neither HIV1 nor HIV2 can enter the cell.

It occurs when light - sensing cells malfunction in a part of the retina called the macula and block the central field of vision.

Auxin pumps, green in these images, are normally nestled in plant cell membranes (left) but accumulated insides the cells when blocked by an inhibitor (right).

The research team found that when a particular mitochondrial fission protein (GTPase dynamin - related protein - 1 — Drp1) was blocked using either gene - therapy or a chemical approach in experimental models of PD in mice, it reduced both cell death and the deficits in dopamine release — effectively reversing the PD process.

Using both breast and lung cells, the team found that metastases were less likely to form when β1 and c - Met were blocked from entering the cell together or were prevented from moving to the special location within the cell.

The research team now discovered that when the fruit fly larvae are starved, FoxO is kept within the cell nucleus, blocking the production of ecdysone.

When the researchers used lab techniques to block this transfer, few egg cells were able to form.

When Barton and colleagues blocked androgen receptor in these cells, the cells died.