Sentences with phrase «when huntingtin»

To study what happens when huntingtin is removed during adulthood, a team of researchers led by Ioannis Dragatsis at the University of Tennessee used a genetic tool to precisely time the removal of huntingtin in a large proportion of cells all over the body.

In mice, when huntingtin is missing from the brain at conception, this causes early and severe neurological problems.

When huntingtin is missing from the entire body and brain, the mice will die before birth.

For this reason, we need to understand more about what happens to the brain when huntingtin is removed.

It's difficult to determine the exact cause of the neurological problems that arose when huntingtin was removed in mice, but the researchers uncovered some interesting clues.

When the huntingtin gene is deleted at an age older than four months, these mice appeared to stay healthy, despite having lost their huntingtin genes in cells all over their bodies.

Not exact matches

Researchers led by Xiao - Jiang Li, MD, PhD and Shihua Li, MD, at Emory University School of Medicine, used genetically engineered mice in which the huntingtin gene can be deleted, triggered only when the mice are given the drug tamoxifen.

When they stained brain samples taken from human Huntington's victims, they found that the characteristic globs consist of full - length mutant huntingtin, rather than peptide fragments from the mutant.

Things go awry when these fragments are drawn toward the globs of abnormal huntingtin, instead of being processed further.

When caspases chopped off small peptides from the mutant region of huntingtin, they thought, the peptides accumulated into the abnormal globs seen in the neurons of Huntington's victims.

Adult mice don't need the gene that, when mutated in humans, causes the inherited neurodegenerative disorder Huntington's disease. The finding suggests that treatment strategies for Huntington's that aim to shut off the huntingtin gene in adults — now in early clinical stages — could be safe.

A quirk of the huntingtin gene might be helpful when it comes to avoiding these «off - target effects».

When a person has too many CAGs in a row near the start of the huntingtin gene, a harmful «mutant» form of the protein is produced based on the instructions in the gene.

Abstract The bulk of interest in the huntingtin protein has centered on the fact that, when mutated, huntingtin causes Huntington's disease (HD), a devastating neurodegenerative disorder.

And when they tracked the striatal neurons carrying the mutant huntingtin over time, they found them much more likely to die than those from other brain regions.

Importantly, both studies suggest that we need to continue our current cautious approach when lowering normal huntingtin in human studies.

That's not what we expect when patients are given huntingtin - lowering drugs, which might produce around 50 - 75 % reductions in the mutant and healthy protein.

We will need to continue to use caution when removing or lowering normal huntingtin in human studies

As expected, they found that the normal and extra-long genetic instructions were both translated into huntingtin proteins when they met up with a ribosome (the chef from our analogy above).

When a cell needs a specific protein - say, the Huntingtin protein - to carry out their function, a request is sent to cells DNA managers.