It occurs
when immune system cells from the donor proliferate and attack the host's tissues.
Not exact matches
The athletic adults also appeared to have healthier and younger - looking
immune systems, at least
when it came to an organ called the thymus that's responsible for generating key
immune cells called T
cells.
Or consider a vaccine that,
when injected directly into a tumor, would not only destroy the malignant
cells but also stimulate the body's
immune system to go after similar tumor
cells.
Eating probiotic - rich foods improves our
immune systems, helps lessen the gaps between the
cells that line our intestinal walls (gaps can be harmful
when they become too large), and restores proper balance of microflora in the intestine.
When you or your child comes in contact with egg proteins,
immune system cells (antibodies) recognize them and signal the
immune system to release histamine and other chemicals that cause allergic signs and symptoms.
We found that
when it comes to cutaneous immunity — specific to skin — the
immune system was being obstructed by skin
cells that were too prone to producing inflammation responses.
When viral and bacterial infections strike, our bodies respond by commanding B
cells within our
immune systems to crank out antibodies to battle the invaders.
A pre-clinical study of two drugs designed to boost T
cell performance, has revealed the agents,
when give in combination, may enhance the
immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN.
When the dendritic
cells are activated, they train T
cells — their allies in the adaptive arm of the
immune system — to attack cancer
cells anywhere in the body, whether at the site of the original tumor or distant metastases.
Typically,
when the body senses a foreign substance such as a virus or a bacterium, it sends
immune cells to attack the invader while also bolstering the
immune system as a whole.
When the T
cells of your
immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop «T
cell exhaustion,» becoming less effective and losing their ability to attack and destroy the invaders of the body.
When researchers injected fresh breast cancer
cells in the side opposite the original tumor site, the disease didn't recur in any of the mice, as the cancer was rejected by the
immune system's memory.
Dendritic
cells catch invaders and tell the
immune system when and how to respond.
There was another intriguing connection: Acinetobacter are molecular mimics of proteins found in myelin, the nerve
cell coating that the
immune system attacks in MS.. That suggests the bacteria might trigger
immune attacks that hit myelin, too, as
when soldiers who inadvertently resemble the enemy get hit by friendly fire.
«
When we analyzed tissue samples in the lab, we found that exposing white fat to macrophage
cells from the
immune system inhibited the transformation.»
The momentum started building in 2010
when the FDA approved Provenge, a cancer vaccine that rallies male patients»
immune systems to attack prostate cancer
cells, allowing patients with an advanced form of the cancer to live several months longer.
Type 1 diabetes occurs
when the body's
immune system destroys the
cells making insulin, the substance that enables glucose in the blood to gain access to the body's
cells.
Hoping to treat the fetus
when its
immune system was especially primitive and the disease in a nascent stage, doctors infused stem
cells into the fetus's abdominal cavity at just 12 weeks» gestation.
When the
immune system is imbalanced, either due to overly - active
cells or
cells that suppress its function, it causes a wide range of diseases, from psoriasis to cancer.
«Something similar occurs in our bodies
when we're infected with these viruses; there are signals our
cells detect that let our
immune system know all is not well,» he said.
The reaction begins
when an antibody activates a component of the
immune system known as a mast
cell, which then blasts out a barrage of chemicals.
When pathogens infect the
cells of the body, the infection sets off a chain reaction involving the
immune system that changes the activity, or expression, of hundreds of genes.
When a T
cell detects one, it morphs into a fighting machine, zapping invaders with lethal chemicals, multiplying into an army of identical killers or signaling other
immune -
system troops to join the attack.
Then there's the West Palm Beach symposium, held to recruit participants for a study testing what happens
when aging people get infusions of plasma (the fluid part of blood packed with signaling proteins and other molecules but no red or white
cells) from young people who've taken a drug meant to activate their
immune system.
HIV infects the body by corrupting T
cells that are mobilized by the
immune system when the virus enters a person's body.
Islet autoimmunity, detected by antibodies that appear
when the
immune system attacks the islet
cells in the pancreas that produce insulin, is a precursor to type 1 diabetes.
Kipnis and his team first suspected a link between the
immune system and social behavior
when they found that mice lacking T
cells, key components of the
immune system, show little interest in their peers.
When fighting chronic viral infections or cancers, a key division of the
immune system, known as CD8 T
cells, sometimes loses its ability to effectively fight foreign invaders.
When we think of how we fight disease, the image of
cells in our
immune system fending off microbial invaders often comes to mind.
The
immune system detects viruses
when viral nucleic acids bind protein receptors in
immune cells.
In the tea drinkers»
immune systems, gamma delta T
cells produced five times more infection - fighting interferon
when exposed to disease - causing bacteria than did the T
cells of the coffee drinkers.
When challenged by a toxin or infection, the
immune system screens this population for a match, then swiftly multiplies the clonal
cell line that produces the matching antibody.
Effector T
cells incite GvHD
when they become overactive as the patient's
immune system starts to rebuild itself from the donor stem
cells.
But
when he injected the mice with genetically identical reprogrammed stem
cells, their
immune systems attacked, destroying the
cells.
When the team looked at what gene signatures the RORγt - dependent ILCs expressed, they found high expression of major histocompatibility complex class II (MHCII) protein, which some
cells use to display foreign proteins to the
immune system and directly interact with T
cells.
Because human T
cells don't have as many of these brakes, our
cells are a hundred times more aggressive than those of chimps
when faced with drugs like TGN1412, which work by triggering the
immune system.
Tests in mice and nonhuman primates had shown TGN1412 to be safe, but
when it was injected into humans — in a dose less than 1/500 of what was given to monkeys — it caused a massive release of infection - fighting T
cells that overstimulated the patients»
immune systems, resulting in multiple organ failure.
The researchers noticed that in highly infected mice, NK
cells produced IL - 10 about 3.5 days into the infection — days later than
when they'd produce IFN - gamma, a protein that helps to mount, rather than defuse, the
immune system response.
A study of the way malaria parasites behave
when they live in human red blood
cells has revealed that they can rapidly change the proteins on the surface of their host
cells during the course of a single infection in order to hide from the
immune system.
But
when we get sick, the T
cells loosen their hold to let the
immune system attack invading pathogens.
When susceptible people come into contact with flakes of cat skin called dander, T
cells in their
immune systems set off a chemical chain reaction that produces the familiar symptoms of allergy, including sneezing, runny noses, itching and asthma.
When a dendritic
cell comes in contact with an antigen that it deems foreign, it carries it to the lymph nodes, where it instructs the rest of the
immune system to attack anything in the body displaying that antigen.
These
cells are now thought to serve as the
immune system's principal sentinels in the skin —
when they detect damage signals from nearby wounded skin
cells, they summon other, non-skin-resident
immune cells to the site of the wound.
It exposes the
immune system to only a handful of bacterial proteins, and it may be that exposure to more — as occurred
when people were inoculated with the whole -
cell vaccine — is more powerful.
When the cancer - causing Epstein - Barr virus moves into a B -
cell of the human
immune system, it tricks the
cell into rapidly making more copies of itself, each of which will carry the virus.
When the animals»
immune systems identify a cancer
cell, a genetic tweak allows their bodies to launch a massive attack of white blood
cells that kills the budding tumor.
When the
immune system stumbles upon an unknown foreign invader for the first time, it often takes days before lashing out with full force — a time during which T
cells start dividing and differentiating into specialized
cells, such as antibody - producing B
cells and killer T
cells.
Sometimes
when the
immune system makes small mistakes, the body amplifies its response in a big way: Editing errors in the DNA of developing T and B
cells can cause blood cancers.
While
immune system cells» purpose is to defend and protect the body, ironically the brain's «call to arms» may cause more harm than good
when it instructs
immune cells to enter into the brain.
When the altered T
cells were delivered back into Olson's veins, his
immune system became a cancer - seeking weapon.