Sentences with phrase «when knockout mice»

That would amplify a trend that began about 15 years ago when knockout mice first became common.

When these knockout mice were fed a high - fat diet, they gained as much weight as normal mice did, but they managed to remain sensitive to insulin.

Days later, when these knockout mice were given the same tasks, the animals regained their expertise faster and more fully than ordinary mice with strokes.

Not exact matches

Over the past five years, researchers observed abnormal brain activity in the SHANK3 knockout mice when compared to controls.

Although the Nppb - knockout mice lived a normal lifespan, when the researchers killed the receptor cells in the spinal cord, the mice died prematurely, suggesting that it could be dangerous to try humans, Hoon says.

Some of these, based on previous studies of knockout mice, seem to play a role in cognition and behavior, including fear responses and the ability to learn new behaviors when given food rewards.

On the other hand, as they aged, these «knockout mice» grew fatter than the normal mice, especially when fed a high - fat diet.

The fact that Connexin 30 knockout mice had a higher number of grafted cells than normal mice, and that some of the grafted cells expressed CONNEXIN 30 is a very important finding when considering cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency.

I haven't changed my genetic makeup when I exercise,» says Mario Capecchi, co-chair of the Department of Human Genetics at the University of Utah School of Medicine and a pioneer in working with knockout mice.

«The one thing that I think that is useful is maybe when people write knockout papers they might describe the housing conditions in more detail,» says Chris Paszty, scientific director at the biotech company Amgen, Inc., headquartered in Thousand Oaks, Calif., who as a postdoctoral researcher at Lawrence Berkeley National Laboratory developed a mouse model for the study of sickle cell anemia.

When they compared the results to the Mouse Genomic Informatics Knockout database they found 123 genes that corresponded with functional annotation of abnormal extraembryonic tissue morphology, 121 associated with embryonic lethality, and 14 with abnormal embryo implantation.

For example, we often screen only 15 - 25 mice when generating knockout models with CRISPR and find that many, if not all, the mice carry a frameshift mutation.

To test their reasoning they conducted a second experiment by crossing mice carrying the prostate - specific IGF - 1R knockout alleles with transgenic mice that develop spontaneous prostate cancer when p53 and select other genes are compromised.

Under the grant, Lexicon will utilize its proprietary gene knockout technology to identify genes that, when knocked out, lead to increased levels of mouse Smn protein.

When researchers express interest in obtaining a certain knockout mouse line, the repositories will send them live mice, frozen embryos, sperm, and / or ES cells, so they can study the mice in their own labs.

As expected, tissue studies of the δ - sarcoglycan knockout mice revealed a distinctively different pattern of muscle damage when compared to the damage the researchers found in knockout mice missing the α - sarcoglycan gene.

If the GH knockout Mice lived longer when being given exogenous GH would that be evidence of another, poorly understood receptor for GH?

Likewise, no effect on dopaminergic cell numbers was observed when DJ - 1 / parkin knockout mice were crossed with mice deficient for either SOD1 or SOD2 and aged to at least 16 months (Hennis et al., 2013).

When homozygous C57BL / 6 - Fabp 4 - knockout mice (B6 - Fabp4 - / --RRB- are fed a high fat diet, they gain even more weight than wild - type B6 DIO mice.