Sentences with phrase «when older mice»

Not exact matches

Maybe the experience of being at a lower division club and seeing older players busting a gut in a mickey mouse environment is enough to give our loanies the motivation and appreciation to succeed when recalled back to the Arsenal?.

«Twas the night before Old Trafford when all through the house Not a creature was stirring not even a mouse;

I was then thinking about superhero characters from my past and what resonated, when I remembered watching reruns of that super old school Mighty Mouse cartoon when I was a kid.

My oldest son made me one of these when he was in grade school, except his was a sleeping mouse.

As for me, when I get to that voting booth I may have to fall back on that old reliable write in favorite, Mickey Mouse.

«When this question came up, I said, «Well, I have no idea,»» recalls Bartke, because the mice were always killed in the lab's endocrinology experiments before reaching old age.

When the mice were just four months old — well before they showed symptoms of the disease — their synaptic mitochondria had accumulated approximately five times more amyloid protein than nonsynaptic mitochondria had.

When the huntingtin gene is deleted at an age older than four months, these mice appeared to stay healthy, despite having lost their huntingtin genes in cells all over their bodies.

The researchers studied mice engineered to develop plaques in their brains when the animals are about 10 weeks old.

«The mice also did not seem to gain weight when they got older, like normal mice do.

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

Cross-sections of mouse ventricles show the visible change in size when old hearts are immersed in young blood.

When Wyss - Coray's team tried a simpler experiment than parabiosis — giving old mice injections of plasma from young mice — they saw similar effects on the hippocampal neurons.

To their surprise, they found that when old and young mice were joined, the muscle stem cells in old mice were revitalized.

When each generation of mice was 15 months old, the researchers measured sex hormone levels, sperm concentrations and sperm motility, or movement (a potential sign of infertility).

Remarkably, the same healing effect was produced when B cells from older obese diabetic mice were applied to acute wounds in similarly aged, obese diabetic mice.

Older mice fared markedly worse when subjected to sleep deprivation.

To achieve a more real - world scenario in this study, they waited until the transgenic mice were a year old, when both cognitive impairments and neuropathology were established, before administering the drug.

When the scientists blocked Treg cells from accumulating in the fat by targeting a molecule that the immune cells require, mice no longer developed type 4 diabetes in old age.

When the pups get older, they will learn to paddle through water mazes or bury black marbles in their bedding, giving researchers insight into how their memory and behavior compare with that of typical mice.

When the researchers injected the protein into the heart muscle of old mice, it became «younger» — thinner and better able to pump blood.

Newborn mice typically exhibit a surge of leptin when they are eight days old that programs the hypothalamus circuits to respond to fullness cues.

When Tilly and his researchers studied mice that lacked the bax gene, they found that 24 - month - old females — the equivalent of 80 - to 100 - year - old humans — still have functioning, estrogen - producing ovaries.

Young mice paired with old mice (left chart, two - toned) made fewer new cells in the brain's hippocampus than when paired with another young mouse (yellow).

Old mice made hundreds more new brain cells when paired with a young mouse (right chart, two - toned) than when paired with an old mouse (teaOld mice made hundreds more new brain cells when paired with a young mouse (right chart, two - toned) than when paired with an old mouse (teaold mouse (teal).

When the researchers fed the ALS - prone mice butyrate in their water, starting when the mice were 35 to 42 days old, the mice showed a restored gut microbiome profile and improved gut integrWhen the researchers fed the ALS - prone mice butyrate in their water, starting when the mice were 35 to 42 days old, the mice showed a restored gut microbiome profile and improved gut integrwhen the mice were 35 to 42 days old, the mice showed a restored gut microbiome profile and improved gut integrity.

Plasma from old mice didn't have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood - brain barrier cells.

Fractured shin bones of old mice healed faster and better when the rodents were joined to young mice than to mice their own age.

When the researchers measured the amount of virus present in different tissues, they found that, in addition to more virus in their blood and spleens, the older mice had 20-fold higher virus levels in their brains — which likely causes the excess deaths.

But now that we know what kinds of changes occur as these cells age, we can ask which of these changes reverse themselves when an old cell goes back to becoming a young cell» — as appeared to be the case when tissues of older mice were exposed to blood from younger mice.

Schöler and his team looked at embryonic mouse clones that were just a few days old to see when and where the Oct4 gene — which helps embryonic cells decide where to go and what to do — is active.

The finding suggests that the mice really had relived an old, bland memory when first introduced to the electric shocks, says Mayford, whose team reports its findings in the 23 March issue of Science.

When the research team gave old mice — the equivalent of 70 - to 80 - year - old humans — water containing an antioxidant known as MitoQ for four weeks, their arteries functioned as well as the arteries of mice with an equivalent human age of just 25 to 35 years.

It wasn't a complete cure, but injected mice could still hear very loud sounds when they were 8 weeks old, unlike uninjected mice (Nature, doi.org/chnx).

When Yousef injected plasma from people in their late 60s into the bodies of 3 - month - old mice — about 20 years old in human terms — the mice's brains showed signs of ageing.

The researchers bred mice deficient for the protein — called placental growth factor (PlGF)-- and broke their tibias under anesthesia when they were 11 weeks old.

When the mice were given this antibody before or at the same time as old blood, they were protected from its harmful effects.

Raised in a germ - free environment, and then given a transplant of gut microbes from a four - day - old normal mouse, these mouse were still able to resist Salmonella infection without any help from their immune system — but only when they had received a dose of added Clostridium first.

But when the researchers added bacteria from 16 - day - old normal mice, the amount of C. rodentium in the guts of surviving mice went down.

All found that old mice get better at learning and remembering when they have young blood circulating in their brains.

When the researchers added GnRH to the hypothalamuses of old mice, they saw that it promoted adult neurogenesis.

As a control, irradiation of wild - type mice resulted in 100 % mortality after a period of 9 months after irradiation, when the mice were 11 months old (Fig. 3 ⇓ shows the survival curve of the females alone for the purpose of simplifying the discussion below); and mortality was mainly attributable to the development of T - cell lymphomas (Table 3) ⇓.

Yet, their efforts to rescue cone function by gene therapy in mid-course LCA stages failed: when applied to 35 - day old Rpe65 - deficient mice, gene therapy restores rod function only (Pang et al. 2010).

Administered in the food of 20 - month - old genetically engineered mice, at a stage when Alzheimer's pathology is advanced, J147 rescued severe memory loss, reduced soluble levels of amyloid, and increased neurotrophic factors essential for memory, after only three months of treatment.

When they looked at brains from these mice, the researchers noticed that hippocampal nerves that were between 1 and 2 months old could dramatically increase or decrease the amount of signaling chemicals they receive from neighboring nerves.

We used 20 - month - old line 85 APPswe / PS1ΔE9 transgenic AD mice (huAPP / PS1) to examine the effect of J147 on the physiological, behavioral and pathological aspects of the disease when administered late in the course of the disease.

When administered in food at a stage when pathology is advanced in 20 - month - old transgenic AD mice, J147 rescued the severe loss of cognitive function, reduced soluble levels of Aβ and increased neurotrophic factors essential for memWhen administered in food at a stage when pathology is advanced in 20 - month - old transgenic AD mice, J147 rescued the severe loss of cognitive function, reduced soluble levels of Aβ and increased neurotrophic factors essential for memwhen pathology is advanced in 20 - month - old transgenic AD mice, J147 rescued the severe loss of cognitive function, reduced soluble levels of Aβ and increased neurotrophic factors essential for memory.

Based upon activity in multiple CNS toxicity assays, we identified an exceptionally potent, orally active, neurotrophic molecule called J147 that facilitates memory in normal rodents, and prevents the loss of synaptic proteins and cognitive decline when administered to three - month - old APP / swePS1ΔE9 mice for seven months [7].

Next, the researchers gave daily injections of TSA to the SMA mice, starting when the mice were 5 days old.

When Kennedy gives the drug to teenage (2 - month - old) mice who have been genetically altered to mimic Pitt Hopkins, they learn better and show dramatically improved memories.