Sentences with phrase «when transplanting cells»

And iPS cells may have a particular advantage: Taking a person's own skin cells, say, making them pluripotent, and then using those cells to grow whatever kind of tissue is needed could eliminate the use of debilitating immunosuppressive drugs, which are required when transplanting cells or tissue from a donor.

Not exact matches

I'm all for making sure the correct breast milk gets to the correct baby, but I don't «transplant» carrot cells into my body when I eat a carrot, or cow tissue when I eat a cow.

Repeated transfection of two expression plasmids, one containing the complementary DNAs (cDNAs) of Oct3 / 4, Sox2, and Klf4 and the other containing the c - Myc cDNA, into mouse embryonic fibroblasts resulted in iPS cells without evidence of plasmid integration, which produced teratomas when transplanted into mice and contributed to adult chimeras.

The team has already successfully repopulated pig kidneys with human cells, but Ott says further studies are vital to guarantee that the pig components of the organ do not cause rejection when transplanted into humans.

The investigators found that when LIF - treated muscle stem cells were transplanted to skeletal muscle, they formed two to three times more muscle fibers as control cells did.

Future research should not only compare how embryonic stem cells, iPS cells and adult stem cells differentiate, but focus on what effects the niche in which these cells will reside, when transplanted, will have on their characteristics, including tendencies to mutate into cancer cells, notes cell and stem cell biologist Olga Genbacev at the University of California, San Francisco, (U.C.S.F.) School of Medicine.

Another challenge is producing stem - cell - derived tissues or organs that don't develop teratomas — tumors that contain a variety of tissues found in different organs — when transplanted.

Because of this, families and doctors often shrink from transplant options, particularly when it comes to treating children, and it will limit the extent to which the breakthroughs in gene therapy and gene editing will be applied, explained Scadden, who is a practicing hematologist at MGH and chairman of Harvard's Department of Stem Cell and Regenerative Biology.

Drs. Prud «homme and Wang also found that GABA vastly improved the survival rate of pancreatic cells when they were being transplanted into mice.

When the team transplanted the cells into diabetic mice whose own beta cells had been destroyed artificially with a chemical, the cells acted like healthy beta cells.

«When we transplanted our labeled blood stem cells from the bone marrow into other mice, only a few stem cells were active in the recipients, and many stem cells were lost,» Rodewald explains.

The results show that germline stem cells can indeed restore fertility when transplanted into other mice, Wu says.

When the human cells failed to thrive, lab workers transplanted those same cells into another mouse.

What he instead plans to do is turn the iPSCs into blood - forming stem cells, which when transplanted into the body would give rise to all of the cell types found in the blood.

This process multiplies the original SSCs by 18,000-fold so there are enough cells to transplant back into the patient when he reaches adulthood.

«We learned a lot with this animal model, but perhaps the most important finding was what we observed when we transplanted skeletal muscle stem cells,» said Kyba.

The team could isolate muscle stem cells from the male mice before they died and when they transplanted them into muscle - damaged recipient mice, they found that the stem cells were able to regenerate new muscle.

Scientists aim to freeze a sample of the boys» testicular tissue so that when they reach adulthood, spermatogonial stem cells (SSCs) found in the tissue can be reproduced and transplanted back into the patients.

New findings presented today indicate that with proper considerations, haploidentical (half - matched) transplants or transplants using cord blood cells can be viable, effective alternatives when a fully matched donor is not available.

Historically, clinicians evaluating a patient for transplant have sought to identify donor cells that are perfectly matched to the patient's cell type, which is considered to be the optimal approach to help ensure successful outcomes and to minimize risk of graft - versus - host disease (GVHD), a serious and potentially life - threatening complication that occurs when the donated immune cells attack the patient's cells as foreign tissue.

One team has grown lung cells that performed their gas - exchange functions when transplanted into living rats.

When these cells were transplanted into diabetic mice, the cells secreted insulin and reduced the blood sugar levels of the mice to normal or near - normal levels.

When transplanted into human cells in the laboratory, the mammoth TRPV3 gene produced a protein that is less responsive to heat than an ancestral elephant version of the gene.

Identification of fibrocartilage stem cells (blue) from the TMJ that spontaneously regenerate cartilage (red) when transplanted in vivo.

When antibodies against the donor's white blood cells decrease to very low levels and the crossmatch becomes negative, the patient is ready for transplant.

Her group wanted to make lung tissue from the body's own cells, to prevent rejection when transplanted.

A decade ago, the medical world was shocked when a patient in Berlin, Germany, had been declared free of HIV after receiving a stem cell transplant to treat cancer.

Abatacept, when added to the standard drug regimen used to prevent GvHD, reduced the occurrence of acute, grade III - IV GvHD from 32 to 3 percent in pediatric and adult patients who underwent mismatched unrelated donor stem cell transplants to treat advanced cancer and other blood disorders.

When transplanted into male rodents with hypogonadism, these so - called Leydig - like cells survived and restored normal testosterone levels.

When they transplanted embryonic brain cells into mice that had already been conditioned to fear a sound, the researchers found these mice were significantly more responsive to extinction training.

When transplanted into the testes of rats or mice with hypogonadism, these cells survived and restored normal testosterone levels.

When the researchers transplanted the cells into mouse spinal cords, the interneurons sprouted and integrated with existing cells.

Nor was it possible to attract T cells into the tumor when the researchers transplanted non-activated eosinophils, which do not produce attractants, into the mice.

Furthermore, when the team suppressed STAP - 2, the prostate cancer cells showed reduced proliferation and did not form a tumor when transplanted into mice.

When transplanted into rats with hypopituitarism — a disease linked to dwarfism and premature aging in humans — the lab - grown pituitary cells promoted normal hormone release.

When newborn cells are transplanted onto «skeleton» of adult heart, it becomes pumping organ in the lab

When facing a scarcity of transplanted bone marrow at the lowest dose, these HSCs prioritized T cell production.

They went on to show that the cells — when moved to new conditions — could then be coaxed to develop into functional nephron - like structures both in the lab or when transplanted into animals.

When transplanted into healthy mice, immune cells activated in heart failure soon brought about inflammation that drove heart failure.

In the future, researchers will have to determine whether similar cells are safe and effective when transplanted.

And when transplanted to a petri dish, they gave rise to the more common type of leukemia cell.

The test monitors fragments of DNA released by the organ into the blood, when cells from the transplant tissue are naturally broken down.

Injections of the cells into mice triggered no tumors, she also reported, and the cells survived for more than 6 months when transplanted into monkeys.

The stem cells knit themselves into this donor matrix and, when the valve was transplanted, functioned well for more than three years.

To their surprise, many of the cells failed to form teratomas at all — similar to what the researchers saw when they transplanted ES cells from one mouse strain to another.

Immunologist Yang Xu of the University of California, San Diego, and his colleagues tested what happened to several kinds of pluripotent cells when they were transplanted into genetically matched mice.

When a soup of nutrients and stem cells is squirted over a matrix, stem cells may grow into a hunk of tissue that can later be transplanted into a waiting patient.

«Stem cells from some infertile men form germ cells when transplanted into mice.»

«When you look at people's recovery — recovery of their T - cells and CD4 + and suppression of viral load — we don't see people losing control of HIV infection, nor do they have evidence of additional immunological deficits following transplant.

The concept was first tested inadvertently in Germany in 2006, when a person with leukaemia who was also HIV positive received a bone marrow transplant that happened to come from someone whose blood cells couldn't make CCR5 proteins.