Sentences with phrase «where gene copy»
The study for the first time estimates the minimum number of locations in the human genome — 250 to 300 — where gene copy number variation (CNV) can give rise to autism spectrum disorder (ASD).
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In cases where a tumor had not doubled the mutated KRAS gene copy, the researchers discovered duplications in other cancer genes.
To stop hepatitis C, any effective drug also had to incorporate itself into the virus's genetic code, where it would need to halt the virus's ability to make new copies of its genes and thus to make new virus.
What that indicates, Gingeras says, is that the long RNA molecules are being copied from near the front of a gene, where they interfere with the gene's production until they are reduced to smaller pieces.
Bennett and her team injected a benign virus carrying a corrected copy of the gene into the boy's retina, where it helped the eye make rods and cones.
In this way, the mutation is somewhat similar to sickle cell anemia in humans, where having one copy of a mutated gene gives one an immunity to malaria, while two copies causes a painful, life - threatening illness.
Where it's subtracted (deletions), they may carry one or even zero copies of a gene.
Therefore, where DNA is added (duplications), they may carry three or more copies of the genes in that DNA segment.
However, such CRISPR screens are sensitive to a phenomenon called the copy number effect, where genes that have been repeatedly duplicated within a cell (as commonly happens in cancer cells) can be flagged as essential regardless of whether they are or not.
We can do this by putting «backup copies» of the mitochondrial genes into the nucleus, where they can not be damaged by free radicals generated in the mitochondria.
In most cases, these should match up, but the methylation patterns would differ in imprinted genes, where one copy would be methylated in the normal blood cells, but neither or both copies would be methylated in the disomy tissues.
This happens by epigenetic silencing of the other copy, where specific marks on the DNA carry a memory of whether a gene sitting on a copy of a chromosome came from the sperm or the egg.
From these data, we first measured allele - specific expression, where a heterozygous site in a gene can be used to distinguish gene expression from the two copies of a gene.
Transcription is the first step in gene expression, where the genes on our DNA are copied into molecules called messenger RNAs (mRNAs).
A dominant mutation is where one defective copy of a gene is enough to affect the individual, whereas a recessive mutation requires that both copies of the gene carry a mutation for the individual to be affected.
Most breeds are fixed for either curly or not - curly, but in breeds where there is variation, dogs may now be tested to see if they carry zero, one or two copies of the curly or non-curly versions of the KRT71 gene.