Sentences with phrase «where targeted therapies»

Our current work focuses on determining the role of the PI5P4K enzymes in p53 deficient cancers, especially the triple negative breast cancer subgroup where targeted therapies have not been effective.

But he adds that the industry has entered a new cycle where targeted therapies, particularly in cancer treatments, means there are some good returns on R&D.

Not exact matches

I also sought firms targeting opportunities where existing therapies had some shortcoming, as well as those with what I saw as a strong product pipeline.

«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.

They give some clues about why these diseases occur, but more detailed maps, such as this, will pinpoint where the problems lie — providing precise targets for therapies.

«Now that we've identified where the replication - competent virus is hiding, we can start work towards targeting these cells with new therapies aimed at fully eliminating HIV from the body,» Associate Professor Palmer concluded.

His team's approach is based on gene therapy, where a «tame» virus is harnessed to transfer a gene into target cells in the recipient.

Because the dorsal nexus is a place where attention, memory, and emotion all converge, its emergence as the target of ECT explains both the therapy's success and the side effects of memory impairment, the authors write.

Their work could overcome a stumbling block for gene therapy by ensuring that a gene is actually inserted into a target cell's chromosome, where it will order the production of therapeutic proteins.

«As we are entering the era where we anticipate there will be many new treatments, each targeting inflammation differently, it is also important to understand the relative efficacy of these therapies in achieving our goal of mucosal healing to appropriately position them in our treatment algorithms,» said Dr. Ashwin Ananthakrishnan, senior author of the Alimentary Pharmacology & Therapeutics review.

Professor Sterk commented: «We are living in an era where we have new biological knowledge and new targets for therapy but we largely continue to guide patient management with diagnostic labels.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

The field has experienced monumental challenges developing new and effective drug therapies, not the least of which was the discovery that — until recently - clinical trials were conducted where up to 30 % of participants did not have the Alzheimer's disease - related brain change targeted by the experimental drug.

Other blood disorders that have shown significant benefit from targeted gene therapy in small trials include hemophilia (specifically, factor IX deficiency), severe beta - thalassemia (deficiency for the adult beta - globin gene) and leukemia, where the patient's immune cells were treated to enable them to recognize cancer cells and destroy them.

Where research uncovers possible mechanisms for disease, those working in drug discovery can use these data to develop novel diagnostic or monitoring tools, to develop therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing — therapies are targeted at the correct subgroup of patients.

She and her team now want to determine whether the medial septum - to - hippocampus circuit can be targeted with therapies to protect DG stem cells and restore normal DG neurogenesis in cases where neurogenesis is abnormal.

We believe that the use of DNA binding agents such as Hoechst can be used to target exposed DNA in other diseases where necrotic cell death plays a critical role and could be used as a platform therapy.

We are developing the next generation of targeted therapies where we eliminate the synthetic lethal partner of the three most common cancer - causing genes: MYC, TP53 and KRAS.

While not necessarily mainstream, you can find various versions on the Internet, including this sinus compress ($ 20; amazon.com), which targets moist heat therapy to the forehead and around the eyes, where sinus pain and pressure typically strike.

In order to optimize the clinical benefits of laser therapy, the wavelength used must be weakly absorbed by water and melanin within the skin yet strongly absorbed by hemoglobin (the part of red blood cells that can be targeted with laser therapy to release oxygen) and the mitochondria (where oxygen is metabolized into energy).

Whether you are seeking ongoing supportive therapy over time or brief and targeted solutions to pressing issues, I will meet you where you are.»

Couples therapy is more about seemingly intractable problems with a relationship history, where emotions are the target and the agent of change.

Couples Therapy is more about seemingly intractable problems with a relationship history, where emotions are the target and the agent of change.