Sentences with phrase «whether epigenetic»

The study authors note that they have not determined whether the epigenetic changes they observed may improve or harm health.

It has also not been shown whether this epigenetic clock is unique to humans or conserved in the more experimentally tractable mouse.

The researchers are now looking at whether epigenetic effects no longer have an impact on great - grandchildren and their subsequent offspring.

But in that study, the authors could not determine whether the epigenetic changes were a consequence of being overweight or the cause of the obesity in the first place.

Further research needs to be done to find out whether this epigenetic signature is just an indicator of breast cancer risk or is involved with the progression of breast cancer.

In order to work out which is the chicken and which is the egg, i.e. whether the epigenetic changes are a consequence of the disease or if the disease is a result of the changes, the researchers also investigated whether healthy individuals had epigenetic changes caused by age, BMI and raised blood sugar levels.

It would now be interesting to learn whether the epigenetic effects of polyunsaturated fat could be involved in an improved carbohydrate metabolism,» concludes Ulf Risérus.

But the jury is still out as to whether epigenetic susceptibility to disease can be passed on to future generations

But it's not clear whether epigenetic susceptibility to disease can be inherited

Mill says twins would need to be scanned regularly throughout life to find out whether epigenetic changes precede the onset of the disorders.

The next step will be to gather more ancient samples from before and after a major environmental change — the end of a glaciation, for example, or the arrival of humans in the New World — to see whether any epigenetic changes correlate with the environmental transition.

«Our next question was whether epigenetic drift could be altered to increase lifespan,» says Dr. Issa.

Not exact matches

Genetic / epigenetic knowledge is important for determining whether there are at - risk women for negative postpartum mood or poor mothering behaviors after exposure to certain birth interventions or birth experiences affecting the oxytocin system.

Epigenetics (literally «above the gene») is a recent scientific development that examines how particular mechanisms can influence whether certain genes are turned off, turned on, or modify a gene's level of activity.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

Even if researchers can pick the signals from the noise, they will then have to work out what the epigenetic changes do, and whether they are in fact adaptive — a tall order given how little we know about interpreting epigenetic signals even in modern DNA.

Shen is now researching whether diet has any effect on the epigenetic changes in mice with cancer.

«The coolest thing from an environmental perspective is that we can ask whether diet can influence this epigenetic process,» say Lanlan Shen of Baylor College of Medicine in Houston, Texas, whose group has developed a way to direct where methylation occurs, allowing them to show that epigenetic changes can trigger tumours (see main story).

The proposed strategy reflects a continuing move toward combination therapies, particularly when it comes to epigenetic approaches, which target the mechanisms that control whether genes are switched «on» or «off.»

The findings show an important role for epigenetics in bumblebees, and suggest that whether a gene is turned off or on depends on whether it comes from the father or the mother.

Epigenetic changes do not alter the information encoded in the DNA sequence itself but determine whether and to what extent specific genes are used by cells.

But Emma Whitelaw of the Queensland Institute of Medical Research in Brisbane, Australia, cautions that the jury is still out on whether endocrine - disrupters are acting through epigenetic mechanisms.

«The goal was to measure the safety in patients diagnosed with MDS or AML and determine whether the drug changed the patients» epigenetic bookmarks,» explained Dr. Issa.

The authors believe theirs is among the first human studies to investigate the influence of phthalate exposure on sperm epigenetics, embryo development and whether DNA methylation in sperm cells may be a path by which a father's environmental exposure influences these endpoints.

So, we're very interested in seeing whether some of these epigenetic modifications can go from one generation to the next, but that remains much more controversial.

In the companion paper, researchers explored whether blocking the PD - 1 checkpoint rewired exhausted T cells to make them, from an epigenetic standpoint, more like functional T cells.

The results show that the epigenetic pattern in more than 3,000 genes (out of approximately 25,000 that exists in a human being) had changed differentially, depending on whether the participants had eaten saturated fat or polyunsaturated fat.

Yet it is still too early in our investigation into the epigenetics of this complex stress - response system to know for sure whether these molecular changes indicate any real - world risks or benefits.

To identify these epigenetic changes, they examined whether genes had methyl groups attached to them.

Romain Barrès, who studies the genetics of metabolism at the University of Copenhagen, wanted to see whether there was evidence of such epigenetic changes in human sperm.

To see whether weight loss would affect sperm epigenetic markers, the researchers collected sperm samples from six men who were about to undergo gastric bypass surgery.

Members of the lab are already starting field experiments to test whether or not these epigenetics play out in local kelp forests, as part of research within the Santa Barbara Coastal Long Term Ecological Research project.

Epigenetic changes are a hallmark of cancer, but up until now, it has not been known whether these changes on their own are sufficient to push healthy cells down the cancer path.

Whether you're foggy on the concept of «epigenetics» or just want to recap the high points of the science of genetics, check out Eissenberg's overview of some of the most exciting advances in the last 50 years: Discoveries in DNA: What's New Since You Went to High School?

Grace Kao, associate ethics professor at Claremont School of Theology, in Claremont, California, mentioned additions she will make to her Introduction to Christian Ethics course, such as discussing epigenetic alterations associated with war trauma for a session on war and peace, the science behind shopping and the ways that poverty can change your genes for a segment about economics, and an exploration of whether genes can predict a person's liberalism and conservatism for a session on religion and politics.

Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile, a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.

AMHERST, Mass. — A new three - year, $ 440,000 study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst is now underway to investigate whether phthalate levels in expectant fathers have an effect on the couples» reproductive success, via epigenetic modifications of sperm DNA.

Using data from blood and brain tissue, a team led by researchers at Johns Hopkins Bloomberg School of Public Health found that they could gain insights into mechanisms that might help explain autism by analyzing the interplay between genes and chemical tags that control whether genes are used to make a protein, called epigenetic marks.

The current work shows that changes in the genetic code of a particular gene can control epigenetic marks at different genes, implying that a gene's genetic code can affect whether other genes are turned on and off, which makes it important to understand the function of all genes involved, not just the one with the so - called misspelling.

The authors first examined whether the location of the observed mutations was correlated with any epigenetic variables.

The study proposes an interesting epigenetic effect, but more data are needed to decide whether it exists.»

Some of the genetic factors that are being researched right now are multiple genes contributing to the disease (there are about a dozen genes that are leading candidates), and the possibility of epigenetic interactions (that is, certain genes and other biological molecules that determine whether and when certain genes present in the body are turned on or off) that may contribute to schizophrenia.

There has been a rapidly increasing interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and thereby affect gene expression and phenotype in humans and wildlife.

This happens by epigenetic silencing of the other copy, where specific marks on the DNA carry a memory of whether a gene sitting on a copy of a chromosome came from the sperm or the egg.

TEST CASE RESEARCHER Piroska Szabó, Associate Professor, Center for Epigenetics, Van Andel Research Institute ORGANISM Mouse METHOD RNA - seq In 2014, Szabó and colleagues reported how they'd used mouse embryonic fibroblasts to test whether the relatively new method of RNA sequencing could reveal known and novel imprinted genes.

Researchers continue to find novel ways to explore these biomarkers using ddPCR technology, whether they are epigenetic markers to determine cancer recurrence after surgery or cell - free DNA (cfDNA) derived from a tumor that reveals the effectiveness of immunotherapy.

Whether these observations reflect causal processes or are confounded by genetic and social factors remains unclear, although animal (and some human) studies suggest that epigenetic programming events may be involved.

The researchers then analyzed the DNA to examine the degree of an epigenetic mark called methylation, a chemical tag on genes related to whether they're «turned on» or «off.»

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

The purpose of this study was to determine whether the Strong African American Families (SAAF) heightened parental depressive symptoms would forecast accelerated epigenetic aging for youths.