«There has always been this question of
whether optic nerve hypoplasia occurred during development or if the visual system degenerated after the normal course of development.
Not exact matches
(CNN)- Christopher Lukasik was building shelves when a metal rod hit his eye, tearing about a third of his
optic nerve fibers and leaving everybody from his doctors to his family wondering
whether he would ever see again.
Of course, visual field testing, looking at the
optic nerve,
optic nerve atrophy,
nerve fiber layer thinning, using optical coherence tomography, but the real question is can we back that up significantly and be able to tell
whether the patient sitting right there in the chair is in trouble?
First based on our completed genetic study we will test if pharmacological inhibition of an identified protein via direct eye injection can promote long distance
optic nerve regeneration or
whether, based on strong preliminary data, manipulation of another novel gene can induce such regeneration.
We seek to determine
whether a particular type of imaging, known as «polarization - sensitive» imaging, is capable of reporting on the integrity of sub-microscopic structures within
optic nerve fibers at an early stage of damage from glaucoma, preceding their complete degeneration and loss from the eye.
We seek in this proposal to determine
whether a particular type of imaging is capable of assessing and reporting on the integrity of sub-microscopic structures within
optic nerve fibers at an early stage of damage preceding their complete degeneration and loss from the eye.
We have some biomarkers for glaucoma that tell us
whether patients have the disease, like visual field tests or imaging, just letting your doctor look at the
optic nerve in the back of the eye is a biomarker for
whether you have glaucoma and, at least at a gross level,
whether it's getting worse.
In this study, we will examine
whether glial cells and certain proteins secreted from these cells influence axon regeneration and guidance in the
optic nerve in adult mice.
Your veterinarian can also use an opthalomoscope to determine
whether there are any changes to the retina and
optic nerve and possibly find the cause of the drainage problem.