The researchers identified 24 potential reprogramming factors — proteins that control
whether other genes in the cell are turned on or off.
The current work shows that changes in the genetic code of a particular gene can control epigenetic marks at different genes, implying that a gene's genetic code can affect
whether other genes are turned on and off, which makes it important to understand the function of all genes involved, not just the one with the so - called misspelling.
Both groups took measurements to see
whether other genes were being affected by the zinc - finger drug, and found results that were broadly reassuring.
The researchers plan to investigate what percentage of individuals individuals with intellectual disability and autism may carry CC2D1A mutations and to determine
whether other genes affect neurons in a similar fashion.
Not exact matches
Before this can happen though, Teixeira said that his team will first have to determine
whether the Stk11
gene or the
other genes and proteins it controls are similarly affected in the human form of BPH.
The researchers are now investigating
whether the guide RNA turns on each of these
genes individually or
whether it activates one or more regulatory
genes that then turn the
others on.
Nearly two dozen of the altered
genes are present in both the hippocampus and the blood, which presents the possibility that scientists could develop a
gene - based blood test to determine
whether a brain injury has occurred, and that measuring some of those
genes could help doctors predict
whether a person is likely to develop Alzheimer's or
other disorders.
Whether or not a gay
gene, a set of gay
genes, or some
other biological mechanism is ever found, one thing is clear: The environment a child grows up in has nothing to do with what makes most gay men gay.
What unites the sociologists, physicists, biologists, and
other scientists studying networks is the recognition that «
whether they're networks of people, computers,
genes, [or] neurons, they often obey similar mathematical rules and have similar properties,» says Nicholas Christakis, a professor of sociology and of medical sociology at Harvard Medical School in Boston.
The researchers now are studying some of the master
genes to determine
whether modifying them also causes changes in large numbers of
other genes.
Other directions for future research, Liu said, include looking at the role of CLOCK in more forms of the disease, learning more about exactly how CLOCK affects neural circuits to disrupt adequate inhibition of excitatory neurons, and examining
whether any of the
genes that CLOCK regulates are especially important in the disorder.
Prof. Khatri and his team studied the way the immune system responds to infection by looking at
gene expression — which
genes are active and which are not — and
whether there are differences in patients with malaria compared to
other infectious diseases.
They argue that anyone whose genome is sequenced for any medical reason should automatically learn
whether 57 of their
genes put them at risk of certain cancers, potentially fatal heart conditions, and
other serious health problems.
Under the new recommendations, the parents would learn not only if their child's heart condition is due to a particular
gene mutation — they'd also learn
whether she is at high risk of certain breast cancers, colon cancers, cardiomyopathies, aneurysms, and
other diseases.
Ressler then wanted to see
whether Oprl1 could be linked to PTSD in humans, so looked at the
gene's sequence in approximately 1,800 highly traumatized civilians, some of whom had PTSD and
others who did not.
Whether the offspring gets the vanilla version of a
gene from a mother and the chocolate version from the father or the
other way around, the trait coded for by the pair of
genes will look the same.
There are two
other genes, on different chromosomes, that code for different forms of the enzyme, and the team is now investigating
whether mutations in these
genes might be responsible for the
other cases of ALS.
But many
genes could have a moderate impact on
whether a person gets diabetes, and many
others could have a minor impact.
Debates are now erupting over the benefits and ecological risks of releasing such insects into the wild — and
whether gene drives could also thwart invasive species such as Asian carp and cane toads, or combat
other animal - borne pathogens such as the one causing Lyme disease.
Such high levels of genetic variation poise mosquito populations to rapidly evolve in response to our efforts to control them
whether that be with insecticides or any
other control measure, including
gene drive.»
He's eager to know
whether this same set of
genes is involved in social responsiveness of
other animals.
«We want to know
whether this fragmentation is resulting in reduced
gene flow or inbreeding or
other things that might be detrimental to the animals.
Much more research is needed on how
gene drive would work under different environmental conditions or
whether the selected
genes would spread to
other species or change in some way over time.
Whether it's a
gene mutation, corrosives or hard labor that eliminates ridges, crease and
other patterns are just as usable, according to Langenburg.
To confirm
whether this new enzyme performed the same role as the
other xanthophyll enzymes, the researchers inserted the CVDE
gene into mutant forms of algae and plants that do not produce zeaxanthin.
Researchers will also want to find out
whether bacterial integrons of
other species can also pick up
genes besides those for antibiotic resistance.
FosB is a transcription factor in the brain which, together with
other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines
whether certain
genes are activated or not.
Before now, researchers wanting to find out
whether disease
genes could be targeted with drugs had to search piecemeal through scientific literature, clinical trials databases or
other sources of information, some of which were not publicly available or easily searchable.
Surprisingly, these conserved
gene sets were also associated with several
other biological traits, which evolved multiple times in ants, such as number of queens in a colony,
whether an ant species is invasive or not, and the degree of worker sterility.
But because some of the
genes could indicate pathogenic characteristics — such as resistance to antibiotics — the researchers want to learn more about the potential health implications, and
whether other buildings house similar biofilms.
Are there tests that pick up
whether a person has
other fitness - related
genes?
But because many
other diseases, from Alzheimer's to multiple sclerosis, also involve myelin
gene changes, it's still not clear
whether these changes are central to the disease.
Of these, a high proportion are so - called command - and - control
genes that help bacteria decide
whether to form colonies or to continue seeking better shelter, possibly making Pseudomonas «smarter» than
other bacteria.
He and
others have recently used
gene - editing tools to correct mutations in human iPS cells but haven't used the same combination of methods or done the same set of experiments to determine
whether the iPS - derived cells are safe.
The second question asked by protesters is
whether genetically modified AcNPV will swap
genes with
other wild viruses, creating new strains that might kill
other species.
The Arizona researchers studied
whether cage conditions affect mice with one copy of a
gene called fibulin - 4, a member of a family of
genes believed to code for proteins that stabilize the connective tissue found between cells in arteries and
other blood vessels.
To determine
whether the reactivation of methylation - silenced
genes by EGCG is a general phenomenon that also occurs in
other cell lines, we studied the effects of EGCG treatment on the methylation status and mRNA levels of p16INK4a or RARβ in three
other human cancer cell lines (Fig. 3C) ⇓.
Based on data from Robinson and
other people who had similar experiences, Newell has been able to identify a pattern of
genes turned on in their immune cells that may predict
whether someone could be able to become «tolerant.»
Rather, how
genes are controlled may help determine
whether we have hair or fur or
other distinct characteristics.
Some of the genetic factors that are being researched right now are multiple
genes contributing to the disease (there are about a dozen
genes that are leading candidates), and the possibility of epigenetic interactions (that is, certain
genes and
other biological molecules that determine
whether and when certain
genes present in the body are turned on or off) that may contribute to schizophrenia.
This happens by epigenetic silencing of the
other copy, where specific marks on the DNA carry a memory of
whether a
gene sitting on a copy of a chromosome came from the sperm or the egg.
The next step, said Driscoll, is to test
other domestic species, and see
whether the same three
genes may contribute to tame temperaments in everything from cats to goats.
However, it is unclear
whether this enhanced interaction selectively facilitates transcription of specific p53 target
genes, including sestrins, or
whether p53 serine18 phosphorylation also regulates specific target
genes by altering interactions of p53 with
other coactivators such as chromatin modifying enzymes.
Then came the real test, determining
whether the recessive yellow
gene drove out dominant
genes for
other colors.
He and Setton were probing for the
genes that dictate their formation, exploring
whether they are, like
other recycled parts, modified legs.
They found that,
whether in cultured cardiomyocytes or the cardiac and skeletal muscles of live B6129SF2 mice, the BCAAem not only promotes mitochondrial biogenesis but boosts the expression of a host of
other potentially life span - extending factors, including proteins in the ROS defense system and SIRT1, the mouse equivalent of the yeast longevity
gene SIR2.
Further,
whether they do develop the disease or not may depend on their lifestyle or
other genes.
HDACs are a family of enzymes which, amongst
other things, influence access to DNA and are involved in
whether specific
genes, such as tumor suppressing
genes, are expressed or not.
The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch
genes on and off and affect how cells read
genes instead of being caused by changes in the DNA sequence — in
other words nutrition and lifestyle choices) impact
whether or not an individual actually develops a specific health issue even though they have a SNP mutation.
The tests will detect
whether the patient has any of the 26
genes that indicate they have a greater risk for developing breast, colon, ovarian, pancreatic and
other cancers