The research team, led by Dr. Michael Shiloh, Assistant Professor of Internal Medicine and Microbiology at UT Southwestern, found that microfold cell (M - cell) translocation is a new and previously unknown mechanism by
which Mtb enters the body.
Not exact matches
He has held senior management and board level positions in purchasing and distribution since 1976 and — while now semi-retired — is currently joint - owner of MSG Sport,
which manages and organises
MTB races in East Anglia.
Several studies published in PLoS Medicine this week conclude that the
MTB / RIF test is very effective at diagnosing TB in HIV - positive patients,
which is particularly difficult because they often have smear - negative results because their TB is disseminated or extrapulmonary.
The results reveal the interactions between
Mtb RNAP and rifampin, reveal the mechanism by
which rifampin inhibits
Mtb RNAP, and enable rational, structure - based design of improved rifampin derivatives for inhibition of
Mtb RNAP.
The innate system — via stem cells in the bone marrow — mobilizes macrophages,
which are a type of white blood cell that swallows and kills invading bacteria like Mycobacterium tuberculosis (
Mtb) that causes TB.
Mtb,
which currently infects nearly 1.5 billion people worldwide and causes more than 1 million deaths each year, requires host lipids — cholesterol and fatty acids — to maintain infection.
To tease out what the LucA protein does, VanderVen's team created a novel LucA
Mtb mutant,
which revealed that the protein encoded by the gene LucA is an integral membrane protein required for fatty acid and cholesterol uptake in
Mtb.
The aim of this work, in collaboration with Bjoern Peters and Alessandro Sette, is to characterize the immune response to dengue virus (DENV) and Mycobacterium tuberculosis (
MTB), both of
which represent major global health challenges.
Another challenge is the need of prolonged antibiotic treatment
which, if not properly completed, accelerates the development of
Mtb multi-drug resistance.
The
Mtb K strain,
which phylogenetically belongs to the Beijing genotype, was first isolated in 1998 in South Korea, when a severe outbreak of pulmonary TB occurred in a senior high school.