Sentences with phrase «which abnormal cells»

For example, women with stage 0 breast cancer may have ductal carcinoma in situ or DCIS, in which abnormal cells have developed in the lining of a breast duct.

(She notes since introducing the mammogram, there has been a five-fold increase in Stage Zero breast cancer, a condition in which abnormal cells are found — but are not actively spreading — in the breast.)

Not exact matches

The cancerous cells win out over the healthy blood cells in the bone marrow, which in turn leads to kidney problems when the cancer cells make abnormal proteins instead of antibodies.

Colorectal cancer occurs when abnormal cells combine to form polyps, which can later become cancerous.

Eating highly refined food products early in the morning will only serve to trigger the body's production of insulin, which will suppress your immune system and promote the growth and spread of abnormal cells in your body.

Jaundice which is due to the rapid, abnormal destruction of the baby s blood cells often resulted, in the past, in serious injury or even death for the baby, but this is different from what most babies are now experiencing.

Although these spots themselves are harmless, if some of the spots are bigger than a 50 cent coin, then it could be due to Neurofibromatosis (NF), which is a genetic disorder of the nervous system that causes abnormal cell growth of nerve tissues or benign tumours to form on the nerves anywhere in the body at any time.

Chronic alcohol consumption causes abnormal fat accumulation in liver cells (steatosis) and liver fibrosis, which can lead to hepatitis, cirrhosis, and sometimes liver cancer.

People with the transthyretin amyloidosis have mutations in the DNA of the transthyretin gene, which causes abnormal buildup and deposits of a transport protein called transthyretin in nerve and heart cells.

In abnormal [PSI +] cells, which are genetically identical to normal cells, the important protein clumps together, and the cells are unable to grow under certain conditions.

Multiple myeloma is preceded by a blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which abnormal plasma cells produce many copies of an antibody protein.

Of particular interest are the emerging techniques for genomics and proteomics, which allow profiles of gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicals.

This turned out to be a normal protein in the cells of organisms throughout the animal kingdom — but in brains infected with scrapie and related diseases it turns up in both a normal, soluble form and an abnormal, insoluble form which accumulates in deposits that eventually kill the cells.

Crizotinib is a drug agent that takes aim at key enzymes within cells called kinases, which are often abnormal in cancer.

At present, Barrett's esophagus and esophageal cancer are diagnosed using biopsies, which look for signs of dysplasia, the proliferation of abnormal cancer cells.

«If I examine cells which exhibit even a slightly abnormal morphology, I immediately consult the physician of record and take more samples.

These pathologies fall broadly into four categories: coagulopathy, where abnormal blood clotting is caused; haemorrhaging, where bleeding occurs; neurotoxicity, which damages the nervous system causing paralysis, and cytotoxicity, where the bite causes death of cells and destruction of tissue.

Aneuploidy is a condition in which cells contain an abnormal number of chromosomes, and is known to be the cause of many types of cancer and genetic disorders, including Down Syndrome.

A form of non-Hodgkin lymphoma, follicular lymphoma develops when the body starts making abnormal B - cells, which are white blood cells that in normal conditions fight infections.

It's thought that the high pressure observed in tumors is a result of these abnormal blood vessels, which leak fluid and proteins into the area between tumor cells, known as the interstitial space.

Vitiligo occurs when the body is triggered to look at melanocytes, cells which give color to the skin, as foreign or abnormal.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

In cells from sick hearts, these channels often don't inactivate properly, allowing for excess sodium entry and a build - up of calcium, which ultimately promotes abnormal heart rate (arrhythmia) and symptoms of heart failure.

The findings may help scientists to better understand the earliest epigenetic changes which can initiate abnormal cell processes, and the transition between the pre-disease state and cancer.

For example, another trial set to start soon will focus on sickle cell disease, in which the oxygen - carrying haemoglobin molecules in red blood cells are abnormal.

The images, when read, are designed to detect cervical intraepithelial neoplasia (CIN), which is the potentially precancerous change and abnormal growth of squamous cells on the surface of the cervix.

For example, Gladstone scientists are researching how autophagy — a process by which cells eliminate abnormal proteins — can help to prevent the destruction of brain cells.

Key findings of this research, which was conducted by Shawn L. Chavez, PhD and her colleagues at Stanford University and analyzed at OHSU, showed that by looking at the duration of the first mitotic phase — a short period in the cell cycle — one can identify chromosomally normal versus abnormal embryos up to approximately the 8 - cell stage.

Flow cytometry (Fig. 4) revealed 57 % medium to large abnormal CD45 (dim +) cells within the nuclear cell gate with atypical cells positive for CD45 (slightly dim +), CD4 (dim +), CD13 -LRB--), CD15 -LRB--), CD33 (+), CD34 -LRB--), CD36 (partial +), CD38 (partial +), CD117 (variably +), HLADR (+), CD14 -LRB--), CD64 -LRB--), CD56 (+), and CD123 (+) which was compatible with BPDCN.

However, using these cell lines it should be possible to determine in detail how the defects arise (which is difficult in patients), and perhaps how to alter the segregation of mutant versus normal mtDNA during cell division to eventually lessen the burden of abnormal mitochondria function.

The abnormal plasma cells make M protein, which is sometimes found during a routine blood or urine test.

In research funded by the Wellcome Trust, Professor Zernicka - Goetz and colleagues developed a mouse model of aneuploidy by mixing 8 - cell stage mouse embryos in which the cells were normal with embryos in which the cells were abnormal.

Plasma cell neoplasms are diseases in which abnormal plasma cells or myeloma cells form tumors in the bones or soft tissues of the body.

Rather, the defective checkpoint system was left to proceed, and one of its downstream consequences, which was still under normal regulation — and one known to be directly induced by the normal degenerative aging process — was reversed at the structural level, by clearing out the p16Ink4a - positive senescent cells that had accumulated to an abnormal degree in their tissues.

Luckily, different cell types tend to have different things on their surfaces, which play particular parts in their specialized roles in the tissue, so it is a matter of identifying and targeting cell - surface markers that are specific to these abnormal cell types.

The glands lining the inner wall of the colon are the sites for most abnormal cell behavior such as uncontrolled cell growth, which results in polyps (non-cancerous growths) and later on in adenocarcinomas or tumors.

In prion diseases, which include mad cow disease and Creutzfeldt - Jakob disease, a normal cell protein, PrP, assumes an abnormal shape.

Now they can form abnormal tangles, which can help kill brain cells.

Understanding the conditions that cause these cells to go off to different fates may have a bearing on health problems such as ectopic pregnancy, which occurs when the embryo develops outside of the womb in about 1 of 60 pregnancies, or molar pregnancy, which is abnormal tissue growth within the uterus that affects about 1 in every 1,000 pregnancies.

We really wanted to find a compound, a chemical, that would profoundly stop the growth of blood vessel cells, which of course are the cells that go on to form the abnormal angiogenesis in wet AMD.

Because, of course, it is this abnormal proliferation of blood vessel cells, which we term angiogenesis, in the back of the eye that is the key feature of wet AMD.

He is best known for his discovery that copy - number variation — a state in which cells have an abnormal number of DNA sections, sometimes associated with susceptibility or resistance to disease — is widespread and significant in the human genome.

Chaired by Prof. Dirk Schadendorf, talks covered topics which included: melanoma epidemiology in the in period since the start of the German National Skin Cancer screening programme (Dr Andreas Strang); an overview of melanoma therapies used in stage IV melanoma; adjuvant therapies and prognosis in stage III melanoma (Dr Lisa Zimmer); tumour heterogeneity, plasticity and resistance in melanoma (Alexander Roesch); epigenomics of normal and abnormal cell differentiation (Bernard Horsthermeke); and, genetics and epigenetics of uveal melanoma (Michael Zeschnigk).

One model, the «specification model», postulates that Toddler's primary role is to promote the specification of endoderm, which when defective leads to abnormal migration of mesendodermal cells (Chng et al., 2013).

A good gyno exam... May Not Include a Pap Smear Pap smears — which detect abnormal, potentially cancerous cells on your cervix — were once recommended yearly for any woman older than 18.

The tests also showed that I had fibromuscular dysplasia, a condition in which there are abnormal cell growths in one or more artery walls.

Unlike NHL, which has many different subtypes, Hodgkin lymphoma is mostly distinguished by the presence of what's called Reed - Sternberg cells, or abnormal types of a specific lymphocyte.

Like caffeine, stress elevates cortisol levels, which suppresses the immune system, making it harder for your body to fight infection and get rid of cells that have become abnormal.

SOOTHING FACIAL MASK: Keep your skin soft, smooth and blemish - free with natural sodium bentonite clay which draws abnormal shedding of dead skin cells and excess bacteria as it dries.

A number of the mechanisms which help prevent abnormal cell growth are avoided in cancer cells.