Sentences with phrase «which act on»

capable of producing and delivering neuroactive substances such as gamma - aminobutyric acid [GABA] and serotonin, which act on the brain - gut axis.

As a class of probiotic, these bacteria are capable of producing and delivering neuroactive substances such as gamma - aminobutyric acid and serotonin, which act on the brain - gut axis.

In Ames dwarrf, Snell Dwarf mice, Klotho mice, GHKO mice who have little IGF and GH; and live longer than wild - type; we see that indeed insulin and glucose / nutrient / energy pathways (which create oxidative stress through excessive nutrient via elevated glycation blood glucose creating high glycated albumin and hemoglobin), that aging is acted on by IGF through hormones, GFs, GHs, acting on insulin signals, which act on survival genes (DAF / SIRT / FOXO).

In addition, climate models and observations suggest that there may be modes of variability which act on multi-decadal timescales, although understanding of such modes is currently limited3.

Therefore, your body produces high levels of blood glucose, which act on many organs to produce the symptoms of the disease.

The sensor measures the forces which act on the surface during the impact, which normally lasts for about 0.5 milliseconds.

Current treatments for neuropathic pain include morphine, which is highly addictive, and gabapentin, which both act on nerve receptors.

Even before the recent genome work, researchers had characterized some of the components of black widow venom, identifying two seemingly unique families of proteins: latrotoxins, which act on neurons; and latrodectins, whose role in venom remains unclear.

Interferons are molecules produced by cells in response to viral or bacterial infection, and which act on neighboring cells to prevent the spread of the infection, shut down protein synthesis, and activate the immune system.

First, the trial tested GM - CSFs which act on more than one blood cell lineage and are not commonly used nowadays.

Whereas Leclerc argued that the ultimate constituents of material reality are mini-substances which act on each other reciprocally and by their interaction co-constitute the new reality of a compound substance (NPE, 309 - 10), Ford argues that such natural compounds are instead to be understood as «single strands of personally ordered actual occasions, potentially divisible into structured societies but not actually so divided» (109).

The baby suckling also stimulates the release of cholecystokinin in the mother, which acts on the amygdala to produce a sense of contentment and wellbeing.

Metformin, which acts on the AMP kinase enzyme, lowers blood sugar and improves insulin sensitivity, thus altering insulin production.

In 1994, Jeffrey Friedman, Marilyn M. Simpson Professor and head of Rockefeller's Laboratory of Molecular Genetics, launched a new era in obesity research by discovering a hormone called leptin, which acts on neurons in the brain's hypothalamus region to suppress hunger.

Your fat cells are responsible for releasing the hormone leptin, which acts on the hypothalamus and slows down the appetite while simultaneously speeding up the metabolism.

It pumps out adrenalin (epinephrine) to tell the liver to break down stored glycogen or amino acids into glucose FAST and dump it in the blood stream, while the nervous systems pumps out acetylcholine, a neurotransmitter which acts on the sweat glands, causing profuse sweating.

, or «gastroc» for short, is the largest muscle in the calf, which acts on both the ankle and knee joints.

No officer or employee of the Service shall engage in the performance of investigative or prosecuting functions of any department or agency in any litigation arising out of a dispute in which he acted on behalf of the Service.

This also meant that Saab finally abandoned the use of parking brakes which acted on the front wheels.

Each clutch is actuated mechanically by an electric servo motor, which acts on the basis of inputs from the same sensors that feed their information into the DSC system: vehicle speed, throttle position, wheel rotational speed, steering angle and yaw rate.

This creates a force which acts on the suspension and dampening of the vehicle in the frequency range up to five hertz.

The crown - gear centre differential works together with the new torque - vectoring system — a first for this segment — which acts on all four wheels.

They'd enrolled in the correct repayment program and filled out an Employment Certification Form with FedLoan Servicing, which acts on behalf of the Education Department.

The first active ingredient is imidacloprid, which acts on the nervous system of the flea to cause paralysis and subsequent death.

In addition there is still clear evidence in my view for aerosols having played a significant role in holding back that warming, which acts on top of the effects of internal variability which play an important role in fluctuations about the forced changes.

Original evidence linking the opioid system to social processes comes from animal studies of the drug morphine, which acts on a receptor in the opioid system, the µ - opioid receptor.

Not exact matches

Instead of a cream, which tends to just sit on top of your face and act like a barrier, Neutrogena's moisturizer is in gel form.

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

The school used the Penn Wharton budget model to analyze the revenue impact of the House's most recent version of the Tax Cuts and Jobs Act, which was approved by the House Ways and Means Committee on Thursday and is set for a vote by the full House this week.

There was the initial act of terror at the Boston marathon, the heroism of first - responders, the dramatic press conference in which the FBI released blurry images of two suspects, the ensuing manhunt, the police shootout — the list goes on.

The Economic Growth, Regulatory Relief, and Consumer Protection Act, which Heitkamp co-sponsored, passed the Senate on Wednesday with 17 Democratic votes.

President Tayyip Erdogan said the state of emergency, which he announced on Wednesday, would enable the authorities to act more efficiently to bring those responsible to justice.

First on the plate is the DREAM Act, which offered a path to citizenship for illegal immigrants who arrived to the U.S. as minors.

A well known example of this strategy is the Tariff Act of 1816, which imposed 25 % taxes on British goods shipped to America in an effort to protect domestic manufacturing.

Wikileaks, in a brief statement Friday on Twitter, made the same point: «Discovery is going to be amazing fun,» said the anti-secrecy group, which has been accused of acting as a cutout for the Kremlin.

«I think the way in which he acts, especially his corrosive effect on norms — truth - telling being the most important of them — has that staining effect on institutions and people who are close to them.

Senate Majority Leader Mitch McConnell on Monday night confirmed what many had suspected — that even a revised version of the Better Care Reconciliation Act (BCRA), which would gut many Obamacare provisions and take a hacksaw to Medicaid, didn't have the support of the requisite 50 Republicans to pass.

The British company said the exploit, which it described as a «criminal act,» had been active for four hours on Sunday.

Toronto Member of Parliament Han Dong has also introduced the Reliable Elevators Act, which mandates maintenance timelines and data collection on elevator traffic.

Amid reports of the damage brain drain inflicts on the economy, Senators John Kerry, Democrat of Massachusetts, and Richard Lugar, Republican of Indiana, Wednesday introduced the Start - up Visa Act, which would open up the U.S. to immigrant entrepreneurs.

«Although it has acted swiftly on the latest UN sanctions, China is unlikely to go so far as to fully implement new sanctions that, in its judgment, would risk substantially undermining the economic well - being or social stability not just of North Korea, but also of the Chinese population near the North Korean border, which relies heavily on such trade,» she said.

One obstacle in Spotify's negotiations is over the share of revenue the service has to pass on record companies — some of which also own minority stakes in Spotify — and their musical acts.

The company, officially acknowledged by the SEC, focuses heavily on quality of investments, returns and trust with their investors, which flies in the face of the worrying statement by Fortune that «now anybody can try being a venture capitalist» under the new rules set by Title III of the JOBS act, allowing anyone to raise up to $ 1 million through crowdfunding.

First, of course, is the Logan Act, which prohibits private individuals conducting negotiations on behalf of the US government with foreign governments,» Deitz said.

Wall Street hated it, but Congress enacted key parts of the accords under the Dodd - Frank financial reform act, which President Trump started to roll back on Friday with the latest of a series of executive orders.

The AMT was permanently patched for inflation through the American Tax Payer Relief Act of 2012, which went into affect on January 1, 2013, and was retro - active for tax year 2012.

On Wednesday, Trump is expected to sign an executive order related to the 1906 Antiquities Act, which enables the president to designate federal areas of land and water as national monuments to protect them from drilling, mining and development, the source said.

Acting Health and Human Services (HHS) Secretary Eric Hargan hasn't said anything about open enrollment at all on his Twitter account during the signup period, which began on November 1.

No, it's not some sort of Mayan end - of - the - world situation, but it is the day on which Wikipedia, Google and a number of other big websites will be protesting the Stop Online Piracy Act (SOPA).

The dispute centered on the interpretation of a 1998 U.S. law called the Digital Millennium Copyright Act, or DMCA, which protects internet service providers from liability when users upload copyrighted content, so long as they remove infringing material once they receive notice or otherwise become aware of it.