Sentences with phrase «which cells repair»

«If we understand how this UV - resistant gene functions and the processes by which cells repair themselves after ultraviolet damage, then we could find targets for drugs to revert a misguided mechanism back to normal conditions,» said Chengyu Liang, the study's senior author and an associate professor of molecular microbiology and immunology at the Keck School of Medicine of USC.

Not exact matches

-- Taki Skouras, CEO of Cellairis, a cell phone repair and accessories brand with 500 locations across the U.S. and which has expanded internationally to Canada, Jamaica, Brazil, Ecuador, Mexico, and Dubai, for a total of more than 600 company - owned and franchise locations

Unlike chemotherapy, which involves administering powerful drugs that kill both cancerous and healthy cells (most healthy cells can repair themselves), immunotherapies harness the power of the immune system to help it identify and knock out just the cancerous cells.

Its drug Niraparib kills cancer cells by inhibiting the production of proteins called PARPs, which help repair damaged DNA strands, thereby hastening the death of some types of cancer cells.

It is also rich in certain proteins, which are essential for cell repair, speeding up healing time, which helps to make your skin look fresher and more radiant.

BCAAs can be used by muscle cells as an energy source, which may help offset muscle breakdown during endurance exercise and help support recovery and repair after weight training.

Carrots have high levels of beta carotene, which acts as an antioxidant to help repair the cell damage that occurs through daily living.

Catalyst AC - 11 Serum goes right to work restoring your skin's DNA and creating more active cells by activating your skin's own zinc finger remodeling process which is a critical part of DNA repair.

Despite a tremendous amount of scientific study, many outstanding mysteries still surround the way in which cells in living tissue respond to and repair physical damage.

The prize in physiology or medicine went to Yoshinori Ohsumi at the Tokyo Institute of Technology for his work on autophagy, the process by which cells recycle and repair themselves.

Natural DNA - repair mechanisms then kick in and put the pieces back together, but in a complete hotchpotch, which usually means the cell will die.

A FATTY apron of tissue called the omentum, which sits over the stomach and intestines, may be the perfect spot to grow patches of cells for heart repair.

A team of researchers at the Stanford University School of Medicine has used a gene - editing tool known as CRISPR to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward developing a gene therapy for the disorder.

Previous researchers have also used cell transplant technologies to repair injured hearts, but these used CMs organized in two dimensions with a random, myofibril structure, which is different from natural heart tissue.

The pairing of the two delivered the breakthrough solution, the researchers said, as neurons responded to the molecule, regenerating synapses in mouse ear tissue that led to repair of the hair cells and neurons, which are essential to hearing.

A 2009 study by the same researchers showed that NF - kB helps normal cells in DNA repair, which may prevent them from harming the body.

Hartgerink is a pioneer in the development of self - assembling multidomain peptide (MDP) hydrogels, which mimic the body's extracellular matrix to encourage the growth of cells and vascular systems for tissue repair.

Larger numbers of T cells were activated in the lean group too, which may relate to repairing damage from the inflammation in the liver.

PARP inhibitors target and block proteins which cancer cells depend on to repair DNA for their survival.

The sperm did show signs of mutation, which could have harmed the mice, but cells at the beginning of gestation have a supercharged ability to make repairs, compensating for the damage.

Studies in rats and dogs have already demonstrated that olfactory ensheathing cells (OECs), which insulate bundles of nerve cells, can help repair damage to the spinal cord and nerves leading to animals» paws.

In the latest experiments the Mitalipov group focused on snipping out the mutated gene in heterozygous cells — a situation in which there was still a «good» nonmutated copy available for the natural cellular repair systems in the embryo to use as a template for repair after the researchers edited out the problematic one.

Simultaneously, the research team in CRAG led by Ana Caño Delgado discovered more details on the root growth and its post-damaged cell repair capacity, which have been published in the Journal of Cell Sciecell repair capacity, which have been published in the Journal of Cell ScieCell Science.

Moreover, a substantial increase in circulating endothelial progenitor cells, which repair damaged blood vessels, was noted after consuming bread made from the ancient grain Verna.

«In other words, at that moment of cell division, the cell miss - identified its own telomeres as damaged DNA, which it then «repaired,» Dr. Orthwein says.

A study published by Cell Press November 7th in the journal Cell has revealed that an evolutionarily conserved gene called Lin28a, which is very active in embryos but not in adults, enhances tissue repair after injury when reactivated in adult mice.

Enzymes direct the repair of the extracellular matrix, the protein - based mortar in which the cells are immobilized.

A major concern of the CRISPR - Cas9 approach, in which the double - stranded DNA molecule is cut, is how the cell responds to that cut and how it is repaired.

Their findings in the study «Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells,» which has been published in The Journal of Cell Biology, suggest that this FDA - approved ovarian cancer medicine has the potential to treat a wider range of cancer types than currently indicated.

DDRs inhibition with a tyrosine kinase inhibitor appears to insulate the brain via blood - brain barrier repair, which prevents harmful immune cells that circulate in the body from getting into the brain where they can indiscriminately attack and kill healthy and sick neurons, like those that have been unable to perform autophagy to «take out their trash,» says Moussa.

One of the genes that MM41 blocks — the BCL - 2 gene — is involved in regulating apoptosis, the body's natural process which forces cells to die if they become too damaged or unhealthy to be repaired.

The treatment is based on making bone marrow cells express the telomerase enzyme, which is responsible for repairing telomeres.

For instance, researchers at other institutions have done animal studies in which they injected cells into the damaged section of the heart to try to repair damage.

To study excision repair in cells, Sancar, Selby and colleagues recently developed a new technique, XR - seq, which allows investigators to isolate and sequence the small lengths of adduct - damaged DNA that are snipped from the genome during the excision repair process.

The method, which involves inserting genetic material that makes the cells» development run backwards, opens the door to stem cells specific to patients, which could be used to repair damaged organs or fight diseases such as Parkinson's and diabetes — crucially, all without the need to destroy human embryos.

In vitro experiments used human colon carcinoma cells with and without MMP9 and mouse embryonic fibroblasts, which are connective tissue cells that make the extracellular matrix and collagen and play an important role in tissue repair.

Montani is now studying if the enzyme is also crucial for the cells which myelinate the brain during postnatal development and if it plays a role in repairing myelin after a lesion, as the ones present in multiple sclerosis patients.

The team at Barts Cancer Institute, part of Queen Mary University of London, have found that a molecule, called focal adhesion kinase (FAK), signals the body to repair itself after chemotherapy or radiotherapy, which kill cancer cells by damaging DNA.

Agata Smogorzewska, head of the Laboratory of Genome Maintenance, wants to understand how cells repair interstrand cross-links, a particular type of DNA damage in which the two strands of the double helix that normally twine about each other become physically linked.

The major advancement with the new study is that it demonstrates for the first time that self - repair in the adult brain involves astrocytes entering a process by which they change their identity to nerve cells.

The dCas9 was further modified to nick the unedited strand, which gooses the cell's DNA repair mechanism into converting the G that originally paired with C into an A that pairs with the new T.

In animals, which do not make polyphenols, resveratrol activates cell defenses such as antioxidation, enhanced DNA repair, and increased output from the energy - producing mitochondria in cells, actions that Sinclair theorizes are responsible for the compound's antiaging effects.

For their study, the researchers examined the Fanconi anemia signal pathway, which coordinates the complex repair of crosslinks, with the aid of genetically modified and unchanged cells.

When stem cells are used to regenerate bone tissue, many wind up migrating away from the repair site, which disrupts the healing process.

I don't know too many other consortia which can integrate expertise in embryonic and tissue stem cell biology, tissue regeneration and repair, bioengineering and nanotechnology, materials science, genomics and bio-informatics.

The groups of cells in which only one of the two genes had been deleted quickly succumbed to the formaldehyde - induced DNA damage; however, the cells lacking both FANCD2 and DNA2 were able to repair the DNA damage and survive.

Knowing the origin of each cell and which genes control their normal function are the foundations for scientists to decipher the disease process and eventually to find out how to guide the cells to self - repair or even to build up a brand new organ using amended cells from the patients.»

However the team from the Krebs Institute for Nucleic Acids at the University of Sheffield found that the key to preventing resistance to a common class of chemotherapy used to treat breast and colon cancer is to change the speed in which the cancer cells repair damage to their DNA that is introduced by chemotherapy.

In a study recently published in the journal Scientific Reports, researchers in USF's Center of Excellence for Aging and Brain Repair say the results of their experiment are an early step in pursuing stem cells for potential repair of the blood - spinal cord barrier, which has been identified as key in the development oRepair say the results of their experiment are an early step in pursuing stem cells for potential repair of the blood - spinal cord barrier, which has been identified as key in the development orepair of the blood - spinal cord barrier, which has been identified as key in the development of ALS.

Best known are the BRCA genes, which cells need to repair broken DNA.