Sentences with phrase «which cellular pathways»

In order to confirm that the cytotoxic effect seen in the amiodarone HCL - treated NSCs was specific to the activity of the drug, we first sought to determine which cellular pathways were affected in the amiodarone HCL susceptible NSC population relative to unaffected dopaminergic neurons receiving the same treatment (Fig.

Not exact matches

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

Rapamycin, which is an inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, has a variety of cellular functions and is known to possess both immunosuppressant and anti-tumor properties.

«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.

«We found that a specific cellular pathway, AMPK - PGC1a, likely plays a key role to reduce mitochondrial function and content, which means that new therapeutic approaches that restore and increase mitochondrial function and content could ameliorate or perhaps even arrest chronic kidney disease.»

EDMONTON, ALBERTA — Researchers have identified a key cellular pathway by which the herbal medicine ginkgo biloba may protect brain cells.

To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.

His lab went on to molecularly decode a number of new components of this cellular starvation pathway, which connects nutrition and exercise to suppression of both cancer and diabetes.

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously uncharacterized genes.

We are also interested in the evaluation of novel agents which inhibit cellular pathways known to be important in myeloma pathogenesis.

Our goal is to identify signaling pathways which control or coordinate these different phenotypic transitions and to evaluate how these pathways can be influenced by the cellular environment, altered in pathological contexts or serve as therapeutic targets.

The Buck's Kennedy is conducting research on cell - signaling pathways, in particular the mTOR pathway, which senses cellular nutrients, oxygen and energy levels and tells cells whether to grow, divide or stop.

There are molecules that cause the autophagy pathway to become more active, increasing the rate at which cellular parts are recycled.

The authors of the study explain that their findings suggest that ketogenic diets could also potentially help normalize pathological behaviors in the human model of schizophrenia by providing alternative energy sources via ketones, the products of fat breakdown, which would substitute the abnormally functioning cellular energy pathways in the brains of people suffering from this disease.

Coenzyme Q10 is an important nutrient that is a cofactor in the mitochondrial electron transport chain, the biochemical pathway in cellular respiration from which adenosine triphosphate (ATP) and metabolic energy is derived.

Autophagy refers to the body's response to a lack of food (fasting) which stimulates a degradation pathway of sub cellular components.

Some are genetically based, and others are «damage» based, meaning they involve chemical pathways within the body which result in damage to cellular structures and body tissues.

Ultimately, free radicals lead to cellular damage, which is a common pathway for cancer, aging and a variety of diseases.