Sentences with phrase «which cellular proteins»

Not exact matches

Non-denatured whey protein is one of the best food sources for boosting cellular anti-oxidants such as glutathione which is your body's master antioxidant.

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

Another symptom of NIV is cellular inflammation and leakage of proteins into the eye, which patients experience as cloudy vision, akin to looking through a fog, with occasional «floaters» or shadows, Mahajan explained.

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

The affected mitochondria could no longer provide the synapses with enough energy, which ultimately prevented the synapses from functioning — providing the first direct link between cellular injury caused by amyloid protein and the characteristic breakdown of neuronal communication that occurs in Alzheimer's patients.

They all use RNA molecules as messengers to transfer the information from DNA to cellular factories called ribosomes, which then build proteins, which in turn drive our metabolisms and form the structures of our cells.

It was a gene called the von Hippel - Lindau (VHL) factor, which encodes a protein that puts a brake on the cellular hypoxia response.

With worms as his subjects, he plumbs the cellular mechanisms driving the complex protein interactions regulating lifespan, some of which — remarkably — have been conserved through evolution all the way from his microscopic Caenorhabditis elegans to us.

Purdue University physicists are part of an international group using spinach to study the proteins involved in photosynthesis, the process by which plants convert the sun's energy into carbohydrates used to power cellular processes.

These long - lived worms had mutations that decreased the production of a protein known as insulinlike growth factor 1 (IGF - 1), which helps drive cellular growth and division.

We all have ras genes, which make proteins that are vital to normal cellular function.

The gene's sequence suggests that its protein may anchor the channel to the cellular skeleton, a steady framework from which it can detect any jostling.

Now, scientists at Princeton have used «designer chromatin'templates — highly customized replicas of cellular DNA and histone proteins, the scaffolding proteins around which DNA is wrapped — to reveal new details about Suv39h1's mechanism.

RNA, widely known as a cellular messenger that makes proteins and carries out DNA's instructions to other parts of the cell, is now understood to perform sophisticated chemical reactions and is believed to perform an extraordinary number of other functions, at least some of which are unknown.

Last, the investigation of informational processing and cellular machineries have revealed that genomes of Asgard archaea, which affiliate with eukaryotes in the tree of life (see the figure), encode proteins that they only share with eukaryotes.

Rapamycin has been shown to extend lifespan and reduce symptoms in a broad range of diseases and, at the cellular level, is known to slow down the rate at which proteins are made.

The researchers developed a computational framework to determine the structure of protein interaction networks in each sample and infer which genes performed different cellular functions within these networks.

Histone proteins can be modified with small chemical groups, many of which are products of cellular metabolism.

According to a groundbreaking study published in this week's online edition of the Proceedings of the National Academy of Sciences, they have chemically synthesized a record - length mirror - image protein and used this protein to demonstrate that a cellular chaperone, which helps «fold» large or complex proteins into their functional state, has a previously unappreciated talent — the ability to fold mirror - image proteins.

Declining ATP levels activate a cellular energy sensor AMPK, which adds a phosphate group to tumor suppressor protein p53, extending the protein's lifetime.

They found that by attaching to a mitochondrial protein called TOM20, alpha - synuclein prevented the mitochondria from functioning optimally, which resulted in the production of less energy and more damaging cellular waste.

The technique, which is described in the study «Detection of interferon - protein reveals differential levels and cellular sources in disease» published April 18 in The Journal of Experimental Medicine, will aid the diagnosis and treatment of numerous autoimmune diseases, including systemic lupus erythematosus (SLE) and dermatomyositis.

The researchers found that the more aggressive the cancer, the higher the expression of this protein, which helps maintain cellular stability.

The viral protein outside the nucleus is somehow preventing the cellular proteins in the nucleus from accessing the viral genome, which is also in the nucleus.

This typical, casual canteen chat only partly reveals the facility's successful lab culture, which encouraged Ramakrishnan to focus on understanding the ribosome, the cellular machinery that turns RNA into protein.

The team knew from previous experiments that ISRIB prevents the cellular stress response by stabilizing a protein called eIF2B, which typically helps turn on protein production.

The latest frontier in this search for cancer telltales is the cellular process of endocytosis, which is the way cells take outside materials like proteins inside.

This latter capability is extremely valuable to biomedical research, which relies heavily on fluorescent probes to label and track proteins, nucleic acids, and other cellular components.

AlteRNAtively, they could increase the risk of cancer by changing the way in which cells transmit genetic instructions from DNA to cellular proteins.

To accomplish this deception biologically, Bartfai and Conti genetically engineered mice to overexpress uncoupling protein 2, which causes the mitochondria in cells to produce heat instead of ATP, the fuel source of cellular activity.

The findings shed new light on the biological nature of protein aggregates, which have been widely considered to be toxic dead - end products, but are increasingly being recognized as a new layer of cellular organization.

Bex acts on a «master regulator» protein called retinoid X receptor (RXR), which controls a network of other cellular proteins.

Dengue virus and Zika virus are both positive - strand RNA flaviviruses, which means that once a virus particle infects a cell, its RNA genome can be immediately translated by cellular machinery into viral proteins to make new virus particles and spread the infection.

Wolfram syndrome is caused by a mutation in the gene encoding a protein called wolframin, which resides in the membrane of the endoplasmic reticulum — another cellular compartment that functions as a manufacturing and packaging system and also acts as a reservoir for calcium ions.

The sugars contain many polar chemical groups, which take the place of water and stabilize cellular proteins and membranes until the parched period is over.

Proteins are responsible for the vast majority of the cellular functions that shape life, but like guests at a crowded dinner party, they interact transiently and in complex networks, making it difficult to determine which specific interactions are most important.

Altering the function of the clock circadian regulator (CLOCK) and brain and muscle ARNT - like protein 1 (BMAL1), which keep cellular functions synchronized with day - night rhythms, could treat metabolic problems.

The addition of a small protein named ubiquitin can mark another protein for destruction, relocation in the cell, or it can turn the protein on or off, which can trigger or stop a cellular process, Luo said.

While normal RNA regulation involves regulated and reversible assembly of RNA - protein particles, both increased cellular age and mutation push the process towards hyperassembly, which leads to altered pools of RNA or RNA regulatory proteins in neurons that contribute to their eventual death.

It is caused by a mutation in the ACVR1 gene, which over-activates a cellular signaling process that is important for embryo development and involves a protein called BMP.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

So far, we know that aspirin inhibits the production of proteins known as prostaglandins, which help control the cellular communication that controls how cells proliferate.

Biologists, biochemists and geneticists who need to visualize the anatomical location of cellular structure, proteins / enzymes, mRNA, and reporter genes within whole tissue are among those who can benefit from this innovative product, which can be used with light microscopy, fluorescence microscopy, confocal microscopy and single / multiphoton microscopy.

Her lab also discovered a hidden regulatory landscape on the surfaces of cellular proteins, which act as traffic cops for telomerase.

Reactive oxygen species (ROS) induce cellular damages at different levels (proteins, DNA, and lipids) which increase the body susceptibility to noxious injuries with the final result to accelerate aging and decrease lifespan.

In fact, they found that TGF - β halts both the transcription of the p53 gene - the process by which cellular machinery reads the DNA code for a gene - and the subsequent process by which the corresponding p53 protein is produced, known as translation.

Moreover; it has been observed that elevated calcium levels and interaction of the membrane bound DAG with protein kinase C (PKC), activates PKC's kinase activity, which is known to regulate the cellular activity of MAPK [41].

For example, cellular reprogramming is an inefficient process because many of the target areas on the genome are covered by other proteins, like a childproof cap on a medicine bottle, which prevents the reprogramming factors from binding there.

The UK patents relate to the CRISPR - Cas9 gene editing systems involving single - guide RNA in both non-cellular and cellular settings (UK Patent No. 2518764) and chimeric CRISPR - Cas9 systems in which the Cas9 protein is modified to provide alternative DNA - modulating activities (UK Patent No. 2537000).

In studying the human placenta, researchers looked at gene expression: the process by which a gene's DNA sequence is converted into cellular proteins.