Sentences with phrase «which cognitive decline»

There is a finely graded inverse association between age and cognitive performance, 3 4 5 but the age at which cognitive decline becomes evident at the population level remains the subject of debate.5 6 7 A recent review of the literature concluded that there was little evidence of cognitive decline before the age of 60.8 This point of view, however, is not universally accepted.5 6 Clinicopathological studies show good correlation between neuropathology and the severity of cognitive decline, 9 10 11 and neurofibrillary tangles and amyloid plaques, the hallmarks of pathology, are known to be present in the brains of young adults.12 13 Emerging consensus on the long gestation period of dementia14 15 also suggests that adults aged under 60 are likely to experience age related cognitive decline.

But the critics are not convinced the tests are a good index of the extent to which cognitive decline affects people in everyday life.

Not exact matches

Lumosity features a series of «brain games» that the company believes can help slow or ward off cognitive decline — but those claims haven't been definitely proven, which is what got the firm into hot water over its marketing in the first place.

Nuts and seeds have all been shown to help keep your brain in tip - top shape, along with being a good source of vitamin E, which is associated with less cognitive decline.

The research contradicts the findings of earlier studies, including one by researchers at Florida Tech in 2003, which suggested that heading in soccer may result in the short term in weaker mental performance, including a decline in cognitive function, difficulty in verbal learning, planning and maintaining attention and reduced information processing speed.

«We found that physical activity has the potential to preserve the volume of the hippocampus in those with increased risk for Alzheimer's disease, which means we can possibly delay cognitive decline and the onset of dementia symptoms in these individuals.

People with mild cognitive impairment were defined as those who have a slight decline in cognition, mainly in memory in terms of remembering sequences or organization, and who score lower on tests such as the California Verbal Learning Test, which requires participants to recall a list of related words, such as a shopping list.

«Factors such as adhering to a healthy lifestyle including a diet that is rich in essential nutrients, regular exercise engagement, and having an adequate cardiovascular profile all seem to be effective ways by which to preserve cognitive function and delay cognitive decline,» said Cohen.

«This is the first study that has associated a decline in cognitive function with gestational diabetes mellitus, which is an early diabetic state that raises the risk of Type 2 diabetes later on,» Keskin said.

More than 5 million Americans are living with Alzheimer's disease, which is characterized by gradual memory loss and cognitive decline.

Although most animals» cognitive abilities decline late in life, only people seem to develop Alzheimer's disease, which can result in severe dementia symptoms.

«Antiretroviral treatment only partially penetrates the blood brain barrier, which means that even if a patient is free of HIV systemically, the virus is still able to rage on in the brain, causing cognitive disorders and mental decline,» Dr. Dadachova said.

«Our study provides further evidence that sleep - disordered breathing negatively affects attention, processing speed and memory, which are robust predictors of cognitive decline,» said senior study author Susan Redline, MD, MPH, Peter C. Farrell Professor of Sleep Medicine, Harvard Medical School.

PET scans which use fluorodeoxyglucose (FDG) as a tracer can be used for neuronal loss, and are useful when a reliable short - term prediction of cognitive decline is needed.

Rush is currently seeking volunteers to participate in the study (www.rush.edu/clinical-trials/effect-weight-loss-diets-brain-health-and-cognitive-decline-study), which aims to show whether a specific diet can prevent cognitive decline and brain changes with age.

Kipnis proposes that with fewer T cells, older people can not effectively suppress the inflammation around their brains — which could play a part in the cognitive decline that people experience as they age.

Now they have demonstrated in vivo for the first time that one dose of this gene injected into the central nervous system prevents the cognitive decline associated with aging in old animals which were treated at a younger age.

The disease is largely attributed to an abnormal buildup of proteins, which can form amyloid beta plaques and tangles in the brain that trigger inflammation and result in the loss of brain connections called synapses, the effect most strongly associated with cognitive decline.

For instance, in addition to presiding over the long - running Leiden 85 - plus study, which tracks cognitive decline and risk factors for heart disease, stroke, and other illnesses in people 85 and older, Westendorp came up with an innovative and inexpensive way to explore the evolutionary tradeoff between longevity and fertility: analyzing old genealogical records of British aristocrats.

The current study, which enrolled 152 adults ages 50 and older, was designed to assess whether silent pathological changes in the brain associated with Alzheimer's and detected with positron emission tomography (PET) can predict cognitive decline.

Basak's laboratory, which is focused on cognitive interventions to improve abilities that decline with age, is conducting further research to evaluate differences among various types of video games, long - term effects of cognitive training using the games, and effects on patients already experiencing mild cognitive impairment.

The precise mechanisms by which gum disease may be linked to cognitive decline are not fully clear and other factors might also play a part in the decline seen in participants» cognition alongside their oral health.

When the researchers looked at brain size, they found that for fighters who had increasing levels of tau over time, there was a 7 percent decline in the volume of their thalamus, which is located in the center of the brain and regulates sleep, consciousness, alertness, cognitive function and language while also sending sensory and movement signals to other portions of the brain.

In that case, the skin cells became striatal medium spiny neurons, which are affected in Huntington's disease — an inherited, eventually fatal genetic disorder that causes involuntary muscle movements and cognitive decline beginning in middle adulthood.

White matter hyperintensities, which appear as bright spots on brain MR images, are associated with accelerated motor and cognitive decline, Alzheimer's disease, stroke and death.

As adults age, changes in physical health can be a natural part of the process, as can cognitive decline, which can range from normal change in cognition to the onset of disorders such as dementia or Alzheimer's disease.

Our study, along with prior studies, supports the notion that «cognitive reserve» resulting from early - life and lifelong education and cognitive stimulation may be a potent strategy for the primary prevention of dementia in both high - and low - income countries around the world.21 However, it should be noted that the relationships among education, brain biology, and cognitive function are complex and likely multidirectional; for instance, a number of recent population - based studies have shown genetic links with level of educational attainment, 22,23 and with the risk for cognitive decline in later life.24 Higher levels of educational attainment are also associated with health behaviors (eg, physical activity, diet, and smoking), more cognitively - complex occupations, and better access to health care, all of which may play a role in decreasing lifetime dementia risk.

Now they have demonstrated in vivo for the first time that one dose of this geneinjected into the central nervous system prevents the cognitive decline associated with ageing in old animals which were treated at a younger age.

A compromised blood - brain barrier, which prevents some materials in the blood from entering the brain, is associated with cognitive decline.

The study subjects underwent a series of cognitive tests in which both groups scored within the normal range, indicating that none of the participants were displaying signs of dementia or other forms of cognitive decline.

As an Associate Professor at OSU, my research has been concentrated in the areas of aging, neuroimmunology, and neurotrauma.Overall, my research aim is to determine the degree to which the bi-directional communication between the brain and the immune system is affected by age, stress, and traumatic CNS injury and to delineate the mechanism by which inflammatory cytokine pathways cause long - lasting complications (e.g., cognitive decline and depression).

He oversees the Cerebrovascular Disease and Aging Laboratories, which focus on migraine, stroke, epilepsy and cognitive decline from aging.

«These disparities lead to poorer functional status, which contributes to greater likelihood of physical and cognitive decline, dependency, re-hospitalization and mortality.

In addition, those adults with APOE e4 gene, in which it is linked to a greater risk of Alzheimer's disease, and who also drank tea regularly, had an 86 percent lower risk of cognitive decline.

Identifying the molecular triggers for the onset of AD - related cognitive decline presently requires the use of suitable animal models, such as the 3xTg - AD mice, which develop both amyloid and tangle pathology.

«Processing speed may be an indicator of cognitive decline, which may be a factor in the reduced benefit with mSMT,» said Dr. Chiaravalloti.

Researchers from the University of Chicago and Argonne National Laboratory have deciphered the three - dimensional structure of insulin - degrading enzyme, a promising target for new drugs because it breaks down not only insulin but also the amyloid - beta protein, which has been linked to the cognitive decline of Alzheimer's disease.

Grabowska is listed as a co-author on the paper, which focuses on the connection between aging, exercise, and cognitive decline.

Magnesium can also enhance the brain's ability to change, heal, and grow new neural pathways, which is essential to slowing down and even reversing cognitive decline.

On that list is Vitamin E, a powerful antioxidant found in oils, nuts, seeds, whole grains and leafy green vegetables, which is associated with slower cognitive decline, a lower risk of dementia, and reduced accumulation of beta - amyloid proteins — a key culprit in Alzheimer's disease.

Wine helps prevent clots and reduce blood vessel inflammation, both of which have been linked to cognitive decline and heart disease, explains Tedd Goldfinger, DO, of the University of Arizona School of Medicine.

PPI use can also lead to vitamin B12 deficiency, which has been associated with cognitive decline.

According to research, exercise helps bring about brain changes which can protect against cognitive decline in individuals at high risk, which includes Alzheimer's disease.

The study results indicate that cognitive decline could be delayed by as much as 2.5 years in older people who eat greater quantities of the berries, which are high in flavonoids

Neuroplasticity naturally decreases as we age, but meditation increases the thickness of the brain's prefrontal cortex, which slows down cognitive decline, preserving neuroplasticity.

Individuals having higher scores were also those who showed a slower rate of decline in cognitive tests, even when other factors, like education level, which could account for the result, were considered.

This is further compounded by elevations in metabolic efficiency (whereby energy expenditure declines beyond that predicted from the change in metabolic mass) and appetite which accompany weight - loss, and may ultimately predispose to weight re - gain.82 Moreover, changes in neural activity within brain regions known to be involved in regulatory, emotional and cognitive control of food intake have also been observed following weight - loss.83

To some extent, this isn't surprising: cognitive decline is often linked to declining ability to carry out everyday tasks, though it's not entirely clear which is the cause and which is the effect.

A 2009 study published in the medical journal «Nutritional Neuroscience» indicated that blackberry intake may have a positive impact on motor and cognitive skills, which often decline with age.

The age - related decline in growth hormone and associated IGF - 1 has been linked to age - related muscle atrophy, increased adipose tissue, and neuronal dysfunction.2, 9 In fact, growth hormone replacement therapy in elderly men has been shown to increase lean body mass.9 Growth hormone therapy (1 mg / day — for 5 months) has also been used to improve cognitive function in healthy adults and adults with mild cognitive impairment.10 While only modest amounts of growth hormone cross the blood - brain barrier, IGF - 1, which is actually responsible for the cognitive benefits, gets across just fine.