Sentences with phrase «which decreases expression»

Three new independently conducted studies show that the increased BHB produced in a ketogenic diet improved the NAD + / NADH ratio which decreases expression of the pro-inflammatory NF - κB gene, resulting in:

Not exact matches

I can only barely convey the context of meaning and quality without which sexual expression becomes a ritual of decreasing satisfaction in the lives of persons.

Religious programs act as a functional alternative to the local church, thus decreasing attendance and involvement by reinforcing the social tendency toward the individualizing of religious experience at the expense of its corporate expressions, and placing a burden on the religious broadcasting organizations which they are not equipped to handle.

Third, when babies experience growth spurts they typically increase their milk intake which can correlate to a decrease in expression output when pumping after feeding.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

They also showed that they could manipulate Klotho expression pharmacologically using the anti-diabetic drug rosiglitazone, which resulted in decreased levels of Wnt5A.

The mGlu2 decrease, they determined, resulted from an epigenetic change, which affects the expression of genes, in this case the gene that codes for mGlu2.

Millar's group and her clinical collaborators, including Emily Chu, MD, PhD, an assistant professor of Dermatology and John McGrath, MD, from King's College, London, also discovered that cracking and scaling of palm and foot sole skin in WNT10A patients is due to decreased expression of a structural protein called Keratin 9, which is specifically expressed in these regions of skin and contributes to its mechanical integrity.

By decreasing the expression of CerS4 in these mice, the Ogretmen laboratory hopes to better define the way in which CerS4 regulates cell migration and metastasis.

Importantly, patients with mutations in a single copy of NKX2.1 often have Brain - Lung - Thyroid Syndrome, which is characterized by respiratory distress after birth and accompanied by decreased surfactant protein expression.

These drugs and other pathways decreased viral gene expression which suggested that the pathway the drugs blocked is important for the replication of EBOV.

They performed transcriptional profiling of HSPCs from NOD mice, which revealed decreased PD - L1 expression confined to HSPCs, compared with C57BL / 6 controls.

They found decreased expression for almost all of the genes of cholesterol synthesis, including a gene called SREBP - 2, which acts as a master regulator for cholesterol production.

Corresponding to upregulated TRF2 expression at 80μM, stem cell markers like CD44 and Oct4 were also observed to be upregulated in Clonospheric HCT116 as compared to Parental HCT116 (Fig. 3a and 3b) Decreasing CD24 expression in clonospheric HCT116 was observed which correlated well with increased stem cell expression (Fig. 3b).

Loss of function of TRF2 resulted in decreased β - catenin expression which was reflected in reduced sphere formation efficiency and decreased spheroid size over a period of 7 days.

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

For example, 2xHAR.142 and 2xHAR.114, like many other HARs, function as enhancers, which increase or decrease the level of a gene's expression.

We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.

Upon longer periods and higher doses of ActD the p53 expression decreased, which may be due to suppression of transcription from all three classes of RNA polymerases.

This gene module consists of a collection of genes which increase or decrease expression together.

While acute THC stimulates appetite, the repeated stimulation of CB1 receptors by THC decreases receptor expression and sensitivity, and long - term stimulation may result in antagonistic rather than agonistic triggering of CB1 receptors, which would dampen hunger signals.

Circumscribing — This is a breakdown of communication, during which expressions of love decrease.

The artist states that sculpture is first and foremost an art of volume, therefore any increase or decrease in volume — even that which occurs when a person loses weight — can be seen as a form of sculptural expression.

A large body of research suggests that psychopathy is associated with atypical responses to distress cues (e.g. facial and vocal expressions of fear and sadness), including decreased activation of the fusiform and extrastriate cortical regions, which may partly account for impaired recognition of and reduced autonomic responsiveness to expressions of fear, and impairments of empathy.