Sentences with phrase «which drove the cycle»

Perhaps the biggest factor has been China, which drove the cycle through boom and now bust.

Not exact matches

In others, recent breakthroughs in science and technology are leading to quick adoption of a medical innovation or approach, which in turn, is helping to drive more investment in the field and creating a virtuous cycle.

In cycling, much of what drives hot products is the trade and consumer press, which influences consumers and, more important, the oh - so - skeptical salesperson at the bike shops.

Along with several other analysts on Friday, including Steve Milunovich at UBS, Sacconaghi also said it was becoming clear that the latest lineup of iPhones had not sparked a massive wave of consumers with older models upgrading their phones, a prediction dubbed the «super cycle,» which had helped drive Apple's stock price up 45 % since early 2017.

The data underscores the challenges the Bank of Japan (BOJ) faces, even after its shock decision last month to adopt negative interest rates, in generating a positive cycle in which rising corporate profits drive up wages and consumption.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

In summary, the key to understanding the current market environment is to explicitly make a distinction between 1) the long - term and full - cycle market outlook, which is primarily driven by valuations, and 2) the near - term outlook for the current «segment» of the market cycle, which is primarily driven by the risk preferences of investors.

«We're entering year nine of the longest uninterrupted auto credit cycle on record, and auto makers and suppliers will find it hard to push earnings much higher, which will drive them to get creative on expanding the multiple.

I believe the drivers this cycle will be Watson (analytics) and blockchain — both of which should drive the services revenue.

Exponential growth early in a company's life cycle should lead to profitability which in theory is be plowed back into the business to innovate and drive further growth — a virtuous cycle.

Bob — I can totally understand that you were exhausted by the «deeper life» approach to Christianity — it is a notion that is so often driven by a dissatisfaction which buffers us constantly about what we are (failing) and what we should be, and it can so easily create a cycle which dis - enfranchises us from the actual riches of grace — which put simply, stem from the fact that God justifies the wicked.

His efforts are mostly made manifest after an election cycle which has just hit the NDC in the face and drove the party into opposition.

They found the reforms have made little or no difference to MP turnover and attendance, which are driven by the parliamentary cycle.

During this time, rainfall was affected by the African monsoon which strengthened and weakened on a 23,000 year cycle driven by the precession of the equinoxes.

Researchers from the Perelman School of Medicine at the University of Pennsylvania, in partnership with ORGANIZE — a non-for-profit organization based in New York which leverages health data to end the organ donor shortage by applying smarter technologies, utilizing social media, building more creative partnerships, and advocating for data - driven policies — The Bridgespan Group — a global nonprofit organization that collaborates with mission - driven leaders, organizations, and philanthropists to break cycles of poverty and dramatically improve the quality of life for those in need — and Gift of Life Donor Program — an OPO which serves the eastern half of Pennsylvania, southern New Jersey, and Delaware — evaluated the metrics and criteria used to measure OPOs across the country, and found significant discrepancies in how potential donors are evaluated and identified.

The driving force behind the events in the radiation belts is the sun, which is in the midst of solar max — the peak of solar activity, which rises and falls over a roughly 11 - year cycle.

«It's the engine that drives the carbon cycle for the whole world, which makes it important when we discuss climate changes.

Researchers in Hawaii found that guppies released in the 1920s drove down native fish populations, perhaps by competing with them for food and living space, and had likely changed the cycle of nutrients in water: Guppy - rich areas showed increased levels of dissolved nitrogen — from ammonium in fish urine and gill excretions — which, in turn, stimulated algae growth.

Even microorganisms, which lack a nervous system, have daily cycles of activity and inactivity driven by internal body clocks known as circadian clocks.

The change is driven by differently timed fruiting cycles between apple trees, which some Rhagoletis prefer, and the North American hawthorn, the native fruit where Rhagoletis have traditionally laid their eggs.

The 20,000 - year cycle is driven by changes in the Earth's orbit around the sun, which affects the amount of sunlight received during any particular season.

My co-authors and I have argued in previous papers that climate cycles on early Mars could have been driven by oscillations in the carbonate - silicate cycle, which would have provided transient warming from the accumulation of greenhouse gases by volcanoes and subsequent loss by weathering.

But in the world of marine microbial ecology, there are very few model systems and associated tools that enable scientists to deeply explore the physiology, biochemistry, and ecology of marine microbes, which drive the ocean's elemental cycles, influence greenhouse gas levels, and support marine food webs.

The energy of this water cycle, which is driven by the sun, can be tapped to produce electricity or for mechanical tasks like grinding grain.

As a result, further understanding of the processes that drive volatile cycling on terrestrial planets is needed to determine the water fraction at which they are likely to become waterworlds.

It is important to note that any potential effects will be spatially and temporally variable, depending on current forest conditions, local site characteristics, environmental influences, and annual and decadal patterns of climate variability, such as the El Niño - Southern Oscillation cycle, which can drive regional weather and climate conditions.

The study does not address whether Proxima Centauri's activity cycle would affect the potential habitability of the planet Proxima b. Theory suggests that flares or a stellar wind, both of which are driven by magnetic fields, could scour the planet and strip away any atmosphere.

Insulin itself will drive insulin resistance which will increase insulin in a self - reinforcing cycle.

That Harding was able to achieve such amazing feats on ice — including the triple axel, which most skaters avoided because of its difficulty — is testament to her inner drive to rise from a life of poverty, survive a cycle of abuse, overcome class bias, endure countless hours of practice, and rely on her talent to achieve a better life.

The 1 % which drives supply - chain market forces into an ever escalating cycle of violence and crime in the second world.

The learning cycle drives home a lesson by having students do an act repeatedly, which helps turn concepts into skills and memory.

The second gear represents a cycle in which students drive their own learning at their own pace, receive immediate feedback, and try again.

The data - driven cycle of assessment, analysis, and action, which is indispensable for increasing student achievement, must be deeply embedded in the school's culture and a top priority for schoolwide improvement.

Use the Audi Drive Select efficiency mode and on S tronic automatic equipped models it'll allow the A3 to coast, which allows them to claw back a couple of extra MPG on the combined consumption cycle.

These engines reportedly have a warmup strategy that makes emissions controls heat up faster, which is in itself not a violation, but may prove so if the system only activates during emissions test cycles instead of real - world driving.

GM says during a recent industry - standard test cycle, a ’19 Silverado 2 - wheel - drive with a 5.3 L V - 8 and DFM operated with fewer than eight cylinders more than 60 % of the time, which is 9 % more than a comparably equipped ’18 model with AFM.

The new 991 Turbo averages 29 mpg on the European driving cycle, which seems very impressive, since this represents a 16 percent improvement over the previous 997 Turbo.

More recently, the EPA added test cycles to account for increased air - conditioner usage, colder temperatures, and more aggressive driving, all of which had an especially profound effect on keeping hybrids honest.

In this mode, drivers can reach a max speed of 83 mph and travel 27.3 miles on a single charge, although that range figure is based on the New European Driving Cycle not the EPA cycle, for which numbers are not yet availCycle not the EPA cycle, for which numbers are not yet availcycle, for which numbers are not yet available.

This unlikely rating is due to the New European Driving Cycle (NEDC), which doesn't take into account the electric energy required to fully charge the battery pack.

Details of the autumn upgrade are understood to include a new 2.0 - litre diesel engine, codenamed Panther, which will be EU6d - compliant for the new WLTP driving cycle, with its real - world emissions and fuel economy testing, plus a new interior and tweaks to the exterior styling.

That concept was followed by the LF - LC Blue (2012), which is a rear - wheel drive concept coupe based on the LF - LC, with Opal Blue body color, Atkinson cycle combustion engine, battery pack, white and brown interior.

On a cycle of combined driving which was predominantly on the freeway at cruising speeds, we saw consumption sitting at 8.1 L / 100 km.

But in real world driving conditions it is a rather different story, with overall consumption that is close to the Panamera Diesel, which now returns a combined cycle figure of almost 45mpg.

It is made up of two widescreen touch - sensitive displays through which you adjust the temperature of your heated seat; cycle through the car's various driving modes; adjust the plotted route in the navigation system; and also achieve just about everything else.

At the same time, both top sportscars are now even more efficient with a New European Driving Cycle (NEDC) fuel consumption of 9.7 litres / 100 km, which is 15 % lower than before.

When cruising at medium to high speeds, the high - efficiency Atkinson - cycle i - VTEC gasoline engine provides propulsion via a high capacity lock - up clutch, which connects the generator motor (always linked to the engine) and the electric drive motor, effectively sending motive power directly from the engine to the drive wheels.

Each press cycles through to another of the four different modes of operation: Hybrid for a mix of electric and petrol power, E-mode to drive on pure electricity, E-save to preserve the level of charge in anticipation of some EV driving later in your journey, and Charge, which force the engine to work slightly harder and top up the battery.

The figure future buyers will probably be more concerned about is the range, which is rated at 600 kilometers in the European driving cycle.

The cars new two - motor powertrain, similar to the one in the Accord Plug - in, allows it to run in 3 different modes: «EV Drive,» which solely runs on lithium - ion battery power, «Engine Drive,» which sends power directly to the front wheels, or «Hybrid Drive,» which mates the 124 kW electric motor to the all - new 2.0 liter Atkinson - cycle engine.