Sentences with phrase «which effective therapies»

However, the pace at which effective therapies have made it out of laboratories and into clinical practice has not met the world's high expectations.

Not exact matches

Then colchicine, which has unusual anti-inflammatory properties, proved effective as a treatment for gout, and eventually became a second - line therapy for pericarditis.

Particularly striking is the mortality trend line for tuberculosis, which falls precipitously from 1838 onward — decades before the bacterium responsible for the disease was identified (1882), and long before the advent of the first effective antibiotic therapy, streptomycin.

One setback for these therapies which use the body's immune system to fight cancers is that they are, at times, more effective in certain patient pools than others.

The idea for the database is to create a single repository for both patients» clinical trial data and the genetic specifics of their cancers, including which therapies they've been given and how effective they were.

Straus has pointed out that effective therapy for homeless alcoholics «must offer substitute reward values for abstinence which will be at least equivalent to the reward value of excessive drinking and which will not require greater effort than is required by drinking.»

Like effective and respectful therapy, persuasion brings about new wants and aims, but it does so, not by coercion or by frustrating desires, but by opening new possibilities, which is the result of divine «creativity.»

The most important limitation to understand is that PRP therapy has really only shown to be effective in research studies which look at the treatment of chronic tendon injuries (tendons connect muscles to bone) such as tennis elbow (irritation of tendons about the elbow).

They taught us how to do Floortime therapy with our daughter, which was extremely effective in breaking through her avoidant behaviors.

The article reports that there are currently no effective medical therapies proven to treat this condition, which may trigger biliary inflammation and fibrosis in affected individuals.

Researchers have new insights into how protective antibodies attack dengue viruses, which could lead to more effective dengue fever vaccines and drug therapies.

This is particularly true for immunotherapy, in which characterization of tumor heterogeneity is essential for choosing the most effective therapy.

Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.

«While immune checkpoint blockade therapy is effective in many cancers, it has been less successful for this particular form of prostate cancer, which has motivated a search for targeted therapies that overcome this resistance.»

Therefore, clarifying which cells can and can not eliminate the plaques is essential for obtaining effective therapies,» explains Elena Galea, a researcher at the UAB's Institute of Neuroscience and ICREA lecturer.

The study, «AKR1B1 promotes basal - like breast cancer progression by a positive feedback loop that activates the EMT program,» which has been published in The Journal of Experimental Medicine, suggests that an inhibitor of this enzyme currently used to treat diabetes patients could be an effective therapy for this frequently deadly form of cancer.

«As prescription opioid use is under national scrutiny and because surgery has been identified as an avenue for addiction, it is important to recognize effective alternatives to standard pharmacological therapy, which remains the first option for treatment,» the authors write.

There are currently no effective targeted therapies to this form of breast cancer, which is therefore often fatal.

Effective therapies for either group of patients have proven elusive because the mechanism by which iron moves into the body has been unclear.

«RYBP would make cancer cells more sensitive to DNA damage, which would make chemo or radiation therapy more effective,» said Mohammad Ali, a postdoctoral fellow and the lead author of the study.

The findings suggest that targeting proteins in the BRAF pathway may open new avenues for treating chronic itch, a condition in which few therapies are effective.

The lab is also working with the Breast Oncology Program at UCSF to make this data part of an adaptive clinical trial called I - SPY, which lets researchers identify the most effective therapies based on patient molecular profiling, and is collaborating with members of the UCSF Institute for Computational Health Sciences (ICHS) to put these and other public data into a centralized database that clinicians can access through an app to help make the most appropriate treatment decisions.

The authors said their results, which they have made publicly available, constitute an invaluable resource to help clinicians predict which chemotherapies will be most effective against tumor cells with particular genetic mutations, and how to rationally combine therapies to prevent cancers from developing resistance.

By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.

The results, which will be published Sept. 24 in JAMA Psychiatry, follow prior Stanford research that found a family - based approach was twice as effective as individual therapy for treating adolescent anorexia patients.

The FDA's medical reviewer's recommendation for approval says, in part, that more trials before approval would «significantly delay effective therapy,» which not only reduces body weight but exerts favorable effects on blood pressure and myocardial oxygen for «patients with a serious disease condition with few treatment options.»

The researchers are now looking at how ICOS signals can be altered to diminish autoimmune disorders and augmented for more effective vaccine development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering of patient's own immune cells to recognize and attack their cancers.

During the study, the participants were observed while on highly active antiretroviral therapy, or HAART, which normally consists of three or more drugs and is currently the most common — and most effective — treatment for HIV - positive adults.

In the Cancer Cell article, the researchers describe how various anticancer drugs, including cisplatin and the targeted therapy vemurafenib, which targets melanomas with the BRAF mutation, become more effective when co-delivered with phenformin.

«It was surprising to see all these significant changes in A1C and body weight without altering medications or activity level and without aiming for weight reduction,» Dr. Hamdy pointed out, «Which tells us that nutrition therapy can be as effective as medications even after a long duration of the disease.»

The results suggest that dual therapy with azithromycin and ceftriaxone, which has been recommended by WHO and many countries to treat gonorrhea, may not prove effective in China.

One is the lack of detectable virus in the blood plasma of patients on effective ARV therapy, which makes it difficult for researchers to assess whether an intervention aimed at curing the infection is working.

According to Saura, «this study opens up new perspectives on therapeutic prevention and treatment of Alzheimer's disease, given that we have demonstrated that a gene therapy which activates the Crtc1 protein is effective in preventing the loss of memory in lab mice».

Alterations in the genetic coding for a nerve cell receptor, which detects a chemical signal that is key to behavioral change, could point the way to designing therapies most effective for patients suffering from schizophrenia, drug addiction and other mental illnesses.

Researchers at Norris Cotton Cancer Center have found an antibody that may be used in future treatments for recurrent small - cell lung cancer, which currently has no effective therapy.

«Targeting with a humanized MAG - 1 can likely be effective, especially when given in combination with chemotherapy, for treating a deadly disease for which there is no effective therapy.»

The field has experienced monumental challenges developing new and effective drug therapies, not the least of which was the discovery that — until recently - clinical trials were conducted where up to 30 % of participants did not have the Alzheimer's disease - related brain change targeted by the experimental drug.

Increasing resistance to existing antiviral therapies and the short time - frame in which these agents are effective highlight the critical need for new treatments, such as Eritoran.

«We urgently need markers to predict which therapies are going to be effective and which will not be effective in individual patients with advanced prostate cancer,» said lead study author Emmanuel Antonarakis, MD, an assistant professor of oncology and urology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore, Md. «AR - V7 testing may be extremely valuable in guiding treatment decisions for men with hormone - resistant disease in the near future.»

Therapies based on immune cells, which target particular tumor molecules, are more specific, but they are not effective against a variety of tumors.

TNBC is deadly because, unlike other types of breast cancers such as estrogen receptor (ER) positive or HER2 amplified breast tumours which have effective targeted therapy, TNBC tumours do not respond to targeted therapy.

«The approach may be extended to additional complex disorders and diseases for which we don't understand the underlying biology but do have drugs that may have some beneficial actions, such as depression, anxiety, schizophrenia and others in need of more effective therapies.

One financially feasible and scientifically reasonable method for determining which therapies are most effective would be to tap into medical records already available through large health networks.

Alternative therapies such as acupuncture and electroacupuncture (EA, which combines acupuncture with electrical stimulation) are effective in reducing pain and, possibly, alcohol - withdrawal symptoms.

Surgery, radiation and chemotherapy do prolong survival by several months, but targeted therapies, which have been effective with other forms of cancer, have not lengthened survival in patients fighting glioblastoma.

Hear about the Science Exchange's Reproducibility Initiative, which aims to reward high - quality, reproducible research and provide a mechanism for industry to identify robust new drug targets for the development of effective new therapies.

The report, which included a recommendation on advancing regenerative cellular therapies, proposed a series of viable legislative actions that Congress could take to help streamline the process by which safe and effective medical products are developed and delivered to patients.

Those early results are very positive, and strongly indicate that the nanoparticles could be useful for assessing how effective a therapy is on a much shorter time scale than current treatments, which usually rely on observing the size of the tumor.

The new studies identify activation of endothelial Toll - like receptor 4 by Gram - negative bacteria as a critical event in formation of cerebral cavernous malformations, a significant predisposing condition for stroke and seizure for which effective medical therapies are lacking.

Thus, this rational transcript engineering approach may represent a unique therapeutic opportunity for a wide range of diseases caused by mutations in the mitochondrial genome for which current effective therapies are lacking (2)