Sentences with phrase «which effects an estimated»

* Celiac disease, which effects an estimated 1 in 133 Americans, is an autoimmune disease which prevents the body from absorbing nutrients.

Not exact matches

However, if we look at estimates of earnings before interest and taxes, which removes the effect of tax payments, the S&P is expected to see an increase of 8.6 percentage points.

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

The effects - laden picture took in $ 41.2 million in U.S. and Canadian cinemas over the extended Easter weekend, researcher ComScore Inc. estimated Sunday in an email, easily topping last weekend's leader, «Pacific Rim Uprising,» which collected $ 9.2 million in ticket sales and fell to fifth place.

In this study, the effects of sea level rise (assumed to continue at present, at the time of the study, rates, which the authors noted was likely conservative), wave fetch, wind speed and direction were examined and the resultant erosion rate was estimated for the Western and Eastern shore of Uppands, Port Isobel and Tangier Island by selecting 10 points along the western and eastern shoreline of all the islands.

A day earlier the American Petroleum Institute had estimated crude oil inventories had risen for the second week in a row, by a hefty 6.18 million barrels, which was only to be expected as the market is prepared for the Hurricane Harvey effects on Gulf Coast refining to linger for another few weeks.

The inputs were run through the IMPLAN model to estimate the overall macroeconomic effects of preserving the status quo, which effectively prevents new pipeline infrastructure from being developed in the region.

The rule, which was issued on Thursday and which the Labor Department estimates will directly affect more than 1.1 million people once fully in effect, enables workers to accrue up to seven days of paid sick leave a year.

in the case of our directors, officers, and security holders, (i) the receipt by the locked - up party from us of shares of Class A common stock or Class B common stock upon (A) the exercise or settlement of stock options or RSUs granted under a stock incentive plan or other equity award plan described in this prospectus or (B) the exercise of warrants outstanding and which are described in this prospectus, or (ii) the transfer of shares of Class A common stock, Class B common stock, or any securities convertible into Class A common stock or Class B common stock upon a vesting or settlement event of our securities or upon the exercise of options or warrants to purchase our securities on a «cashless» or «net exercise» basis to the extent permitted by the instruments representing such options or warrants (and any transfer to us necessary to generate such amount of cash needed for the payment of taxes, including estimated taxes, due as a result of such vesting or exercise whether by means of a «net settlement» or otherwise) so long as such «cashless exercise» or «net exercise» is effected solely by the surrender of outstanding stock options or warrants (or the Class A common stock or Class B common stock issuable upon the exercise thereof) to us and our cancellation of all or a portion thereof to pay the exercise price or withholding tax and remittance obligations, provided that in the case of (i), the shares received upon such exercise or settlement are subject to the restrictions set forth above, and provided further that in the case of (ii), any filings under Section 16 (a) of the Exchange Act, or any other public filing or disclosure of such transfer by or on behalf of the locked - up party, shall clearly indicate in the footnotes thereto that such transfer of shares or securities was solely to us pursuant to the circumstances described in this bullet point;

Valuation — with regards to valuation of the company at $ 240 per share, this includes valuing the business at $ 216 per share (at 18x our FY 2016 earnings estimate of $ 12 per share) plus net cash per share of $ 24 ($ 150 billion of net cash less the tax effect on international cash for repatriation, which we estimate to ultimately be 6 %, and for simplicity purposes, apply to all cash on balance sheet rather than just the international cash).

A surge in Australia's terms of trade has mitigated the effect of these developments on the trade deficit, which is estimated to have been around 3 1/4 per cent of GDP in the December quarter 2004, wider than at mid year but broadly similar to the outturns of the past year and a half (Graph 32).

Trans Mountain identified the WTP [Westridge Tunnel Portal] site as a priority for the Project and indicated that approval by 15 February 2018 would allow sufficient time for the WTP site clearing activities, estimated to take four to six weeks, to be completed prior to the migratory bird restrictions which come into effect on 26 March 2018.

The year - ended inflation rate rose to 1.7 per cent, or 2.2 per cent abstracting from the estimated effect of the health insurance rebate which reduced the March quarter CPI.

The Government also sets out its policy priorities and new spending initiatives in the budget, many of which ultimately come into effect through the Estimates process.

Tax cuts always effect assets prices, regulations are estimated to account for up to 35 % of building new construction costs for homes in some locations and though federal deregulation may not impact local regulations as much it does have a multiplier effect on the economy just like a tax cut does and anticipation of an infrastructure plan the scale of this administration's, though it hasn't been passed, would also have an anticipatory effect on leading indicators like stocks and other commodities that raise costs, which we have already seen.

They see forests as having a beneficial effect on weather and agriculture, the value of which can hardly be estimated.

In terms of own price elasticity values, a recent meta - analysis estimated an average own price effect for carbonated sugar sweetened drinks (a near equivalent of the category non-concentrated sugar sweetened drinks, which predominantly includes carbonated drinks) of − 0.93, larger than our value of − 0.81.51 Our estimated value is also at the lower end of the range of own price elasticities frequently cited for sugar sweetened drinks of − 0.8 to − 1.0, based on one large review.52 Our own price estimate is comparable to experimental data (a 25 % reduction for a 35 % price rise) in a canteen study.53 However, all these estimates may be influenced by US studies in which higher estimates may reflect higher levels of consumption.

We used the estimates generated to derive the change in energy intake, which we then used to model the effect on average body weight and prevalence of obesity in the UK (fig 1 ⇓).

Another meta - analysis7 found that various types of neuromuscular and educational interventions appear to reduce the incidence rate of ACL injuries by approximately 50 %, but that the estimated effect varied appreciably among the studies, the reasons for which were unexplained.

Our thought is that, because of a result of nondifferential misclassification, which, as we stated earlier, is inherent in many of the studies reviewed, the actual effect of breastfeeding is higher than the one estimated here.

Two prominent studies find modest effects, in one case estimating that each 1 % increase in the share of migrants in the UK working age population leads to a 0.6 % decline in the wages of the 5 % lowest paid workers, which would mean about 3p less per hour for someone earning just over the minimum wage of # 6.19.

Without urgent and ambitious government intervention, NEA estimates that in the next 15 years the cumulative effect will be 125,000 premature deaths as a result of living in cold homes; # 950m of fuel debt which will not be spent in local economies; and # 22 billion spent by the NHS in treating cold - related conditions.

The plan, which took effect in April, is estimated by the governor's office to save $ 79 billion over 30 years, but not provide for immediate to local governments.

The Oneida Nation Settlement which was signed in 2013 and went into effect in March of 2014 generates an estimated 12.5 million a year to the County in shared gaming revenue.

In the last boundary changes which took effect in 2010, UK Polling's estimate was that Labour's net loss relative to other parties across Britain would be 28 seats (based on the 2005 result) or 8 seats with a 5 % swing from Labour to the Tories which is what happened (see note below).

Using several techniques to gauge the effects of these mutations, which are the most common type of variant in the human genome, Akey estimated that more than 80 percent are probably harmful to us.

«We estimate that their total radiative forcing is around -1.3 [watts / meter2],» which is a cooling effect, he says.

«When you look at a satellite picture of sulfur dioxide, you end up with it appearing as hotspots — bull's - eyes, in effect — which makes the estimates of emissions easier.»

By some estimates one in 5,000 Zika patients develops GBS, but the question of whether the vaccine — which would contain some viral DNA if not the whole virus — will also cause this rare side effect will not be adequately answered in small trials that contain less than 100 volunteers.

As a result, estimates of coastal vulnerability — which once focussed on sea level rise — now have to factor in changing patterns of storm erosion, more intense storms, and other coastal effects.

While other typical synaesthesias are estimated to have an overall prevalence of 4.4 per cent, the vEAR effect has recently gained some prominence on social media following the rise of «noisy GIFs», and in particular the «thudding pylon» GIF which received thousands of retweets.

The hazard quotient is the ratio of estimated specific exposure to a single chemical over a specified period to the estimated daily exposure level at which no adverse health effects are likely to occur.

In his new paper, Lovejoy applies the same approach to the 15 - year period after 1998, during which globally averaged temperatures remained high by historical standards, but were somewhat below most predictions generated by the complex computer models used by scientists to estimate the effects of greenhouse - gas emissions.

Limitations of the study acknowledged include the difficulty in isolating SSRI effects from those of their indications for use, lack of information on SSRI dosage precluded dose - response analyses, and the relatively small sample of DD children resulted in imprecise estimates of association, which should be viewed with caution.

The model used a fixed time horizon of 20 years to estimate costs and effects, which is likely to give conservative estimates of cost - effectiveness of the interventions.

«This is the first study that looks at all seven impact effects generated by hazardous asteroids and estimates which are, in terms of human loss, most severe,» said Clemens Rumpf, a senior research assistant at the University of Southampton in the United Kingdom, and lead author of the new study published in Geophysical Research Letters, a journal of the American Geophysical Union.

«The main challenge of the study was to estimate the long - term effect of erosion, which causes craters to disappear over time,» says Hergarten.

An interdisciplinary team of researchers at the University of Bayreuth has now discovered that there are arsenic compounds which have a toxic effect on plants and yet had not previously been considered in connection with chemical analyses of rice and the estimated health risks for humans.

We used PET and [11C] raclopride (radioligand that binds to D2 / D3 receptors not occupied by DA) to assess the effects of methylphenidate (MP) on the nondisplaceable binding potential [BPND; ratio of the distribution volume (DV) in striatum to that in cerebellum], which is the most frequent model parameter used to estimate DA changes (27), in 24 healthy controls and 24 marijuana abusers.

For one, scientists have yet to mimic the exact effects of Parkinson's in mice and rats, because the disease — which strikes an estimated 60,000 Americans per year — is so complex.

, global transportation infrastructure, the effects of sea level rise on sea level toxic waste dumps (there are many) and the posited future of the further industrialization of China and India, which is to be largely (80 % by some estimates) to be coal powered.

«Their use of western U.S. tree - ring composites (which includes «Bristlecone Pine» data), as we understand it, specifically accounts for potential non-climate related effects originally proposed by Graybill and Idso, and explicitly estimated by Mann et al (1999).»

The core difficulties in social communication, which can mean children not even being able to communicate verbally, and the rigid and repetitive behaviours usually have a profound effect on development into adulthood and result in estimated # 1 - 1.5 million lifetime societal costs per child.

Aldrin et al produce a number of (explicitly Bayesian) estimates, their «main» one with a range of 1.2 ºC to 3.5 ºC (mean 2.0 ºC) which assumes exactly zero indirect aerosol effects, and possibly a more realistic sensitivity test including a small Aerosol Indirect Effect of 1.2 - 4.8 ºC (mean 2.5 ºC).

Although it is uncertain how much brain progranulin would need to increase for a therapeutic effect, reaching the lower limit of normal, which is commonly defined as the fifth percentile of the control group (2 SDs below the control group mean), is a reasonable estimate.

To explore the possibility that frailty (which is associated with both low cholesterol and death28 29) could confound these results, we did a sensitivity analysis adjusting our Cox models (table 4 ⇑) for two known markers of frailty (changes in body weight and changes in systolic blood pressure).28 29 30 These adjustments did not materially change the effect estimates, which remained significant in both groups.

The total of -0.7 W / m ^ 2 is the same as the best observational (satellite) total aerosol adjusted forcing estimate given in the leaked Second Order Draft of AR5 WG1, which includes cloud lifetime (2nd indirect) and other effects.

Third, the biggest hits have minuscule effects — less than 0.05 % of the variance — which means that hundreds of thousands of SNP associations are needed to account for the 50 % heritability estimated by twin studies.

Since the pretransmission ancestral line was included in both the pretransmission and posttransmission experiments, the effect of mosquito transmission (and its standard error) on the N - lines and I - lines, which was not measured directly (i.e., in a single experiment), could be estimated by reference to this line.

The EPA publishes a reference dose (RFD) for silver which is an estimate of daily exposure to the entire population that is unlikely to be associated with a significant risk of adverse effects over a lifetime.