Sentences with phrase «which gene transcripts»

It could help reveal which gene transcripts could serve as early signs of toxicity and which drug combinations might be particularly dangerous, for both new and existing drugs.

Not exact matches

Researchers know that cells chop single genes into shorter pieces called exons, which they mix and match into one transcript for creating a protein.

She bred a mouse in which the antisense transcript was «knocked down» and the paternal copy of the gene turned on.

The same agents that damage DNA also damage its sister molecule messenger RNA (mRNA), which ferries transcripts of the genes to the tens of thousands of ribosomes in each cell.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Since using the WormBase name of W01A8.1 (MDT - 28) would be misleading, the gene is referred here by the cosmid name W01A8.1, which gives rise to at least three protein isoforms designated W01A8.1 a, W01A8.1 b, and W01A8.1 c from at least seven different transcripts (W01A8.1 a. 1, W01A8.1 a. 2, W01A8.1 b. 1, W01A8.1 b. 2, W01A8.1 b. 3, W01A8.1 c. 1, W01A8.1 c. 2).

Vega is different from other genome browsers as it has a standardised classification of genes which encompasses pseudogenes and non-coding transcripts.

Real rates of change can only be determined from actual transcript numbers, and this gives us the kinetics of gene expression which we are interested in.»

For example, cluster 5 of the concise «Time Series», which consists of transiently induced genes around day 3 of differentiation, similarly to Global Cluster 30, contains the same transcripts, but in addition, it also includes T - brachyury, Axin2, Mesp2, Fgf8, Wnt8a, Sp5, Sp8, Follistatin, Mix1 and Lim1.

In addition to well - described genes, clusters often contain transcripts the function of which has not yet been associated with a specific biological process thus providing novel unexplored links to known molecular pathways.

It is important to distinguish lineage specific gene expression shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many loci noted previously in ES cells [23].

The functional annotations of all the clusters with ≥ 10 transcripts, which were obtained using the on GO classification categories of the g: Profiler tool for all the genes in each cluster, are shown in Table 2 (for downregulated genes during ES cell differentiation) and Table 3 (for upregulated genes).