Sentences with phrase «which genes affect»

«In a way, we're modeling one mechanism through which genes affect disease or traits, which is the regulation of gene expression level.»

Now I am trying to understand the specific mechanism by which these genes affect CD1d dependent antigen presentation.

Mice in which a gene affected by Williams syndrome is experimentally deleted show increased separation anxiety.

Not exact matches

But what's really significant in the research is the identification of which genes are selectively affected by consumption of dietary fat or by capsaicin.

Additionally, the agency would continue efforts to advance precision medicine and cancer genomics in support of the Million Veteran Program (MVP), which aims to collect blood samples and health information from one million veteran volunteers to study how genes affect health.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

Specific genes affect the risk of leprosy, says Amos, which may drown out the subtler effects of relatedness.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

As Saaïd Safieddine, CNRS Director of Research at the Institut Pasteur and co-senior author of the study with Prof. Christine Petit (head of the Genetics & physiology hearing unit at the Institut Pasteur), explains, «we have just shown that it is possible to partially correct a specific form of hereditary hearing loss accompanied by balance problems using local gene therapy performed after the embryogenesis of the ear, which is primarily affected by the mutation responsible for the disorder.

Yang said the study not only indicated which genes are affected by traumatic brain injury and linked to serious disease, but also might point to the genes that govern metabolism, cell communication and inflammation — which might make them the best targets for new treatments for brain disorders.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

The clones also appeared to have an effect on the gene expression of the pregnant cows themselves; on day 34, some uterus tissue showed grossly different gene expression, which could affect the placenta.

The answer may lie in epigenetics — the mechanism by which environmental influences affect gene expression.

However, microgravity can reduce cell growth, alter gene expression and change the pattern of root growth — all aspects which critically affect plant cultivation in space.

He has been able to piggyback on previous work on the development of the chick embryo: When researchers interested in some process use a stain to show gene activity, the stain affects the whole embryo, providing clues about which genes are active in tail growth.

The stem cell gene therapy could be applicable for 60 percent of people with Duchenne, which affects approximately 1 in 5,000 boys in the U.S. and is the most common fatal childhood genetic disease.

«It doesn't show how the presence or absence of the menopause affects Darwinian fitness,» how successful an individual is in passing on his or her genes to future generations, «which is the all - important evolutionary yardstick.»

Prof. Reiner had identified this gene — LIS1 — back in 1993, and has continued to investigate its role in the developing brain and in the disease, which affects one in 30,000 births.

«However, there is emerging evidence that epigenomic changes such as DNA methylation and histone modifications, which affect the ways in which genes are transcribed and translated into proteins, are important features of these processes,» he continues.

Researchers have documented many cases in which multiple genes each affect a trait a little bit.

Researchers would then have to pore through four or five databases for each one, trying to discern which genes (or the proteins they encode) have features most likely to affect the biology of the disorder — a painstaking task.

But because the gene appears to affect only the cat's color, white tigers are simply genetically healthy variants of Bengal tigers, which, if bred carefully, might still survive well in the wild.

To better understand how HMGA1 affected the rodents» intestines, Resar and Lingling Xian, M.D., Ph.D., research associate at the Johns Hopkins University School of Medicine, and their colleagues examined the transgenic animals» intestinal cells to determine which ones were expressing this gene.

Genetic cues from male Aedes aegypti mosquitoes passed on during sex affect which genes are turned on or off in a females» reproductive tract post-mating, including genes related to blood feeding, egg development and immune defense, according to new Cornell research.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

The mGlu2 decrease, they determined, resulted from an epigenetic change, which affects the expression of genes, in this case the gene that codes for mGlu2.

The Newcastle University study suggests that an as - yet undiscovered gene controls whether a man's sperm contains more X or more Y chromosomes, which affects the sex of his children.

Unlike genetic mutations that affect DNA and the genome, epigenetic markers turn genes on and off to regulate cell processes, which if altered may lead to disease, he explains.

Everything from the temperature where a body is found to the deceased's age could potentially affect how many and which genes are active after death.

Studying how genes affect different drugs manufactured by different companies gives Poirier greater influence on future drug development, he feels, which would not be possible if he was employed at any one pharmaceutical research lab.

But there could easily be hundreds of epilepsy genes, he says, many of which may not be affecting potassium channels.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Future studies, she says, may be able to shed light on specific genes that affect academic achievement, which could help diagnose or treat learning disabilities.

In two of these regions, the differences were attributable to alternative alleles of just one gene: teosinte glume architecture (tga1) and teosinte branched (tb1), which affect kernel structure and plant architecture.

Such an in - depth analysis of gene expression may help clarify the course and origin of common liver disorders, including liver cancer and non-alcoholic fatty liver disease, which affects about a fifth of the population in developed countries.

By studying rare «copy number variations,» which are individual errant insertions or deletions of DNA segments (each of which occur in less than one percent of the population), researchers discovered a new cluster of genes that are affected in some autistic individuals as well as a number of mutations that were present in autistic children but not their parents.

There is increasing evidence of important associations between the level of methylation [which affects how strongly your genes are expressed] and features of your environment such as diet, stress and poverty.

A team including researchers from Rensselaer Polytechnic Institute have discovered that a specific gene may play a major role in the development of a life - threatening birth defect called congenital diaphragmatic hernia, or CDH, which affects approximately one out of every 3,000 live births.

Researchers have found that a small change in a fruit fly gene affects the frequency at which they sing to their mates, Ars Technica reports.

Neva Parker is head of laboratory operations at White Labs, which helps brewers and wine - makers better understand how yeast genes affect taste.

The teams» three papers, each on Nordic dogs (Swedish Vallhund and Norwegian Elkhound) and each addressing blinding ocular diseases affecting both dogs and people, identified genes causing retinal disease and glaucoma, which may lead to gene therapies for dogs and humans.

Keene and his collaborators used fruit flies in their study and created various scenarios between sleeping and foraging to test each gene one at a time to determine which gene didn't affect their sleep.

While the researchers emphasized the study sample was too small to draw firm conclusions, it appears yoga may modulate the body's epigenetic response, which turns certain genes on or off, affecting physical as well as mental health.

A significant finding by the team was that either the mutant KRAS gene or another cancer gene is amplified, depending on which tumor suppressor gene is affected and to what degree its function is impaired.

It's difficult to determine which genes are heritable, or controlled by your DNA, versus those that may be affected by the environment.

The epigenetic pattern consists of molecules known as methyl groups, which are placed on the genes and affect their function and gene expression.

Choroideremia is caused by defects in the CHM gene, which produces a protein called REP - 1 and affects one in 50,000 people.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

«The parts of the human genome linked to complex diseases such as heart disease, cancer and neurological disorders can often be far away from the genes they regulate, so it can be dificult to figure out which gene is being affected and ultimately causing the disease.»

«It also affected the expression of certain genes in the brain that are involved in «neuroplasticity», which may be associated with memory impairment,» says Morris.