Sentences with phrase «which genetic association studies»

This symposium discusses the degree to which genetic association studies can inform us about development, what the conceptual and practical challenges are, and how such models help us to understand organismal evolution.

Not exact matches

In conducting their study, which includes detailed behavioral, medical and genetic observations of 14 boys with CS from 12 families, the team of scientists and physicians worked closely with families of the small but fast - growing Christianson Syndrome Association, including hosting the group's inaugural conference at Brown's Alpert Medical School last summer.

«Given the similarities in the molecules and the mechanisms involved in limb development in vertebrates and invertebrates, the fly is a very useful genetic model in which to identify new genes that potentially participate in limb development in vertebrates and their possible association with congenital diseases,» says Ana Ferreira, who has participated in the study.

Genome - wide association studies, which try to find correlations between particular genetic variations and disease diagnoses, are a staple of modern medical research.

Professor Jeremy Pearson, Associate Medical Director at the BHF, which part - funded the study, said: «By using the power of very large scale genetic studies, this research is the first to show that the known association between increased height and a lower risk of coronary heart disease is at least in part due to genetics, rather than purely down to nutrition or lifestyle factors.

Biologists typically look for genetic connections by using genome - wide association studies, which statistically associate genetic markers with disease.

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

The research team, following up on a previous genome - wide association study by researchers at Baylor College of Medicine, investigated genetic variations in a protein called FBN - 1, which is essential for a strong arterial wall.

If this is true, then there are important implications for genetic association studies, which often rely on surveys of common genetic variation in the human genome.

«PrediXcan tells us which genes are more likely to affect a disease or trait by learning the relationship between genotype, gene expression levels from large - scale transcriptome studies, and disease associations from GWAS studies,» said study leader Hae Kyung Im, PhD, research associate (assistant professor) of genetic medicine at the University of Chicago.

deCODE MI ™ The deCODE MI ™ test detects two SNPs located on chromosome 9p21, discovered by deCODE and which various genome - wide association studies have confirmed as the highest impact genetic risk factor for heart attack and coronary artery disease identified to date.

July 25, 2011 Two genetic variations predict second cancers after radiation treatment for children with Hodgkin lymphoma A genome - wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin's lymphoma are most likely to develop radiation - induced second cancers years after treatment.

Benefits: There is no direct benefit of this study for you or your dog at this time; however, if a genetic association can be identified, a test could be developed that would predict which dogs carry the trait and may pass it on to their offspring and which dogs may develop the disease in their lifetime.

Furthermore, dog breeds provide genetic isolates, each having a specific predisposition towards compulsive behaviours, which increases the feasibility of conducting genetic association studies.

Genetic association studies suggest that variation within the genes of central neurotransmitter systems, particularly the serotonin (5 - HTTLPR, MAOA - uVNTR) and opioid (OPRM1 A118G), are associated with individual differences in social sensitivity, which reflects the degree of emotional responsivity to social events and experiences.

Considering the complexity of mental illnesses etiology, which involves multiple interacting genetic, environmental and biological factors; large effect sizes are unlikely to be detected; therefore the magnitude of the associations described in this community - based study are noteworthy and possibly indicative of clinical relevance.