The mental sensations of self, desire, fear, love and hate seem better understood in the light of Fields's discoveries about the manner in
which glia interact with neural synapses and interact with one another.
Not exact matches
Although the prevailing idea has been that the devastating disease,
which strikes some 1 percent of U.S. adults, is primarily caused by something going wrong with neurons, the scientists suspected the brain's support cells, called
glia.
Glia - making cells from people with schizophrenia also mostly failed to turned into astrocytes,
which help neurons connect and determine when those connections, or synapses, fire.
These neurons and the synapses between them are supported by long, tree - shaped cells called Müller
glia (in green),
which may provide a new therapeutic target for treating degenerative eye diseases.
The study published in Cell Metabolism reports a mechanism by
which two types of brain cells, neurons and
glia, normally support each other's functions.
Using a technology called VAST,
which can automatically label individual neurons,
glia, and blood vessels different colors, as well as smaller structures such as dendrites and mitochondria, the researchers analyzed the contents of three cylindrical chunks of brain tissue, each no bigger than grains of salt.
A new study just published in the journal
Glia and available online on July 11th, details the newly discovered mechanism by
which astrocytes are involved in inhibitory synapse formation and presents strong evidence that Transforming Growth Factor Beta 1 (TGF β1), a protein produced by many cell types (including astrocytes) is a key player in this process.
Sometimes referred to as the stem cells of the zebrafish eye, Müller
glia are the cells from
which all other types of retinal cells are regenerated in the fish.
(E) R5 antibody labels Müller
glia (Mü; red),
which extend processes the breadth of the flank retina.
They release more and more neurotoxic chemicals, and those, in turn, excite neurons, creating a feedback loop: overstimulated
glia cause more and more inflammation,
which activates stronger pain signals from neurons and amplifies pain.
The stem cell closely resembles the radial glial cell in structure and behavior and, like the radial
glia, has radial fibers
which newborn neurons migrate along up to the neocortex.
In 2010, Kriegstein's lab discovered a new type of neural stem cell in the human brain,
which they dubbed outer radial
glia (oRGs) because these cells reside farther away from the nurturing ventricles, in an outer layer of the subventricular zone (oSVZ).
In essence, most pathological conditions in the mammalian retina lead to changes in Müller
glia — often called reactive gliosis,
which might be analogous to the response of astrocytes upon injury of other brain regions.
hGDAsBMP also expressed connexin 43 (CX43), glutamate transporter 1 (GLT - 1), AKAP12 and
glia - derived neurotrophic factor (GDNF), all of
which are expressed in the astroglial lineage [23]--[25].
Panretinal donor cell migration also affords better access to Müller
glia,
which bind and mediate host responses to some neurotrophic factors, including GDNF [26].