Sentences with phrase «which grafted cells»

Dr Astrid Limb's expertise focuses on investigations into overcoming natural barriers for retinal stem cell transplantation, to create a permissive environment in which grafted cells could functionally integrate.

Not exact matches

In this pilot study to test the safety of putting iPS - derived cells into humans, the six are all receiving a graft of new retinal pigment epithelial cells, which serve to maintain the eye's light - sensing cells.

Historically, clinicians evaluating a patient for transplant have sought to identify donor cells that are perfectly matched to the patient's cell type, which is considered to be the optimal approach to help ensure successful outcomes and to minimize risk of graft - versus - host disease (GVHD), a serious and potentially life - threatening complication that occurs when the donated immune cells attack the patient's cells as foreign tissue.

Hina had developed the devastating immune reaction known as graft - versus - host disease, in which donor cells attack the walls of the gut, skin, lungs, liver, and sometimes — though rarely — even the patient's brain.

In fact, the new approach is similar to an established treatment for severe burns, in which sheets of healthy skin are grown from a patient's own cells and grafted over wounds.

To do this, they switched from using dead tumour cell samples to patient - derived tumour cell lines, in which fresh samples of a person's tumour are grafted onto mice and grown to the required volumes.

A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.

Graft - versus - host disease is a condition in which the patient's immune system is attacked by the donor stem cells.

Another approach to taming the donor graft relies on a mixture of anti — T cell anti-bodies called antithymocyte globulin, which is produced in horses or rabbits.

Now, in a study recently published in the journal PLOS ONE, a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of hCMV and the onset of graft - versus - host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant.

«The unique aspect of our procedure, which no one else in the world is doing, is the formation of blisters as the source of donor cells combined with laser surgery to prepare the grafted areas.

The results, published online today in the Proceedings of the National Academy of Sciences, suggest that lacing the grafts with stem cells enhances blood flow and boosts the production of molecules that make and maintain erections, all of which makes for a better penis reconstruction.

That approach, which shuts down the hyperactive donor T cells when they first arrive, has not only allowed patients to tolerate grafts from increasingly mismatched hosts but, in several recent studies, has also cut rates of severe acute and chronic GVHD to less than 15 %.

The current research team, which includes Dr. Minoda and Dr. Hiroki Takeda of Kumamoto University, and several researchers from Keio University, have successfully grafted human iPS - derived cells into the inner ear of embryonic mice, a feat with a high level of technical difficulty.

However, Takebe's liver bud has the advantage of being grown from iPS cells, rather than, for example, the primary human hepatocytes used in Bhatia's graft, which could make it useful in modelling rare diseases or examining the specific genetic backgrounds of the iPS cell donors.

We grafted donor (YFP - only or EFTF / YFP - expressing) pluripotent cells to host embryos from which one of the two eye fields had been removed (Figure 3A and 3B).

The new immune system that grows from the donor stem cells can recognize myeloma cells as «foreign» and kill them, which is known as the «graft - vs - myeloma» effect.

Individual grafts, one - cell - thick and 1.2 to 3.2 square feet in area, were gently applied to prepared «wound beds,» where the natural bacterial residents had been removed and thread - like fibrin protein laid down, which prevents shrinkage before dissolving.

The researchers say using the CCR5 mutant donation and / or the presence of graft versus host disease, which results in the elimination of HIV - positive reservoir cells that survive irradiation, played a significant role in curing the Berlin patient.

Despite a mild case of graft - versus - host disease (a condition in which donor cells can irritate the host's immune system), which is being managed with medication, Cavalancia says she doesn't feel sick at all: «I feel like I am going to live until I'm 90.»

They are adding proteins, which are key to maintaining the skin; increasing the number of cells to analyze exposure to sunlight; and adding vasculature (blood vessels), which can be used for regenerative medicine and for creating skin grafts.

A delay or misdiagnosis of these types of fractures can result in paraplegia or quadriplegia; the need for bone grafts, pins or screws to stabilize the bone; joint replacement in the future; or avascular necrosis, a serious condition in which bone cells die prematurely due to an interruption in blood supply.